An Amphipathic Alpha-Helix in the Prodomain of Cocaine and Amphetamine Regulated Transcript Peptide Precursor Serves as Its Sorting Signal to the Regulated Secretory Pathway by Elías H. Blanco (391481)

“…These findings show that an amphipathic alpha-helix is a key cis-structure for the proCART sorting mechanism. …”

Mutation in DDM1 inhibits the homology directed repair of double strand breaks by Seung Hee Choi (627451)

“…Here, we show that mutation in a SWI2/SNF2 chromatin remodeling protein (DDM1) causes hypersensitivity in the DNA damage response via defects in single-strand annealing (SSA) repair of double-strand breaks (DSBs) as well as in the initial steps of homologous recombination (HR) repair. …”

Toward Complete Exfoliation of the Chemisorbed Two-Dimensional Iron Silicates on Ru(0001) via Hydrogenation by Kayahan Saritas (1643980)

“…Here, using density functional theory calculations, we systematically investigate the hydrogenation of such overlayers as a way to decrease the substrate–overlayer interactions. …”

Data_Sheet_1_Effects of Arbuscular Mycorrhizal Fungi on Rice Growth Under Different Flooding and Shading Regimes.XLS by Yutao Wang (205998)

“…Further analyses indicated that flooding and shading both reduced the AMF colonization and extraradical hyphal density (EHD), implying a possible reduction of carbon investment from rice to AMF. …”

Evaluation of emerging NASH therapies: the impact of treatment efficacy profiles on long-term health outcomes: Supplementary materials by William L Herring (14039541)

“…<p>Aim: Evaluations of nonalcoholic steatohepatitis (NASH) treatments require predicting lifetime outcomes</p> <p>from short-term clinical trials. Materials & methods: A Markov model with NASH fibrosis stages F0–</p> <p>F3, NASH resolution, compensated cirrhosis (F4/CC), and liver-related complication (LRC) states was</p> <p>developed using literature-based standard of care (SoC) data. …”

RLIPC elevates ST segment prior to induction of cardiac ischemia in rat model of arrhythmia. by Zhaoyang Hu (312662)

“…<p><b><i>A)</i> Left</b>, typical ECGs from CON and RLIPC rats during baseline periods showing elevated ST segment in RLIPC-treated rats. …”

Image_1_Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma.TIF by Zhen Tang (2977569)

“…Therefore, our results explain one underlying mechanism of increasing the sensitivity of osteosarcoma to chemotherapy and suggest that Sestrin2 is a promising gene target.</p>…”

Bilayer Charge Asymmetry and Oil Residues Destabilize Membranes upon Poration by Fernanda S. C. Leomil (17988863)

Secondary metabolites from <i>Gentiana cruciata</i> L. and their anti-inflammatory and analgesic activities by Rima Konya (14075753)

“…<p>A previously unreported secoiridoid glycoside, cruciatoside (<b>1</b>) was isolated from the aerial parts of <i>Gentiana cruciata</i> L. along with ten known compounds eustomoside (<b>2</b>), eustomorusside (<b>3</b>), gentiopicroside (<b>4</b>), 6'-<i>O</i>-β-D-glucopyranosyl gentiopicroside (<b>5</b>), loganic acid (<b>6</b>), isoorientin (<b>7</b>), isovitexin (<b>8</b>), isovitexin 2''<i>-(E)-</i>ferulate (<b>9</b>), mangiferin (<b>10</b>), and 2-methyl-inositol (<b>11</b>). …”

Data_Sheet_2_Effects of Arbuscular Mycorrhizal Fungi on Rice Growth Under Different Flooding and Shading Regimes.docx by Yutao Wang (205998)

“…Further analyses indicated that flooding and shading both reduced the AMF colonization and extraradical hyphal density (EHD), implying a possible reduction of carbon investment from rice to AMF. …”

Table_2_Microbial communities are thermally more sensitive in warm-climate lizards compared with their cold-climate counterparts.DOCX by Xia-Ming Zhu (8601639)

“…To elucidate the role of gut microbiota in thermal adaptation, we designed a 2 species × 3 temperatures experiment, whereby we acclimated adult males of two agamid lizard species (warm-climate Leiolepis reevesii and cold-climate Phrynocephalus przewalskii) to 20, 28, and 36°C for 2 weeks and then collected their fecal and small-intestinal samples to analyze and compare the microbiota using 16S rRNA gene amplicon sequencing technology. …”

DataSheet_7_Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine.pdf by Dominique Bollino (14245121)

“…In addition to the expected decrease of plasma glutamine and asparagine, we observed a significant increase in plasma serine and glycine post-crisantaspase. …”

Fingolimod Increases CD39-Expressing Regulatory T Cells in Multiple Sclerosis Patients by Nathalie Muls (664147)

“…CD39 is an ectoenzyme that cleaves ATP to AMP and has been suggested as a novel regulatory T cells (Treg) marker. As ATP has numerous proinflammatory effects, its degradation by CD39 has anti-inflammatory influence. …”

Residual polysaccharides from fungi reduce the bacterial spot in tomato plants by Tarsis Aguiar (5021966)

“…Furthermore, PRC and PSHII (1.5 mg.mL–1) could decrease disease severity in all tested cultivars. …”

MPs^PPARα+/+-induced EPC differentiation and <i>in vitro</i> angiogenesis of mature ECs involve NF-κB pathway activation. by Tarek Benameur (196206)

“…<p>(<b>A</b>) Western blot showing that MPs^PPARα+/+ induced I-κB phosphorylation on activator sites (Ser32/36) in EPCs, indicating that NF-κB pathway is activated. …”

Table_5_Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients.docx by Haifeng Lu (465603)

“…<p>Background: Cirrhosis is a common chronic liver disease characterized by irreversible diffuse liver damage. …”

DataSheet_1_Elevated fruit nitrogen impairs oil biosynthesis in olive (Olea europaea L.).pdf by Ran Erel (1878358)

“…These results agree with those reported for oilseed crops for which a trade-off between oil and protein was proposed as the governing mechanism for the negative response to elevated N levels. …”

Effect of long term depletion of Shield-1 in NF54::pS4-GFP-HA-DD24 cultures on <i>surf</i> gene transcription. by Tatiane Macedo-Silva (4351135)

“…<p>In <b>A</b>, dynamics of the <i>surf</i>4 and <i>surf</i>9 relative transcript quantity at given time points after removal and re-addition of Shield-1. …”

Data_Sheet_3_Metabolomics and Microbiomics Reveal Impacts of Rhizosphere Metabolites on Alfalfa Continuous Cropping.pdf by Ruiting Wang (6830171)

“…<p>Alfalfa long-term continuous cropping (CC) can pose a serious threat to alfalfa production. However, the mechanism of alfalfa CC obstacle is unclear as of today. …”

Data_Sheet_13_Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma.ZIP by Zhen Tang (2977569)

“…Therefore, our results explain one underlying mechanism of increasing the sensitivity of osteosarcoma to chemotherapy and suggest that Sestrin2 is a promising gene target.</p>…”