Pre-existing CD4+ T cell immunity to non-cognate core epitopes drives the rapid production of isotype-switched, higher avidity antibodies against target antigens. by Thomas Hills (351639)

“…<p>CSP-specific IgG1 (a), IgG2b (b), IgG2c (c) and IgG3 (d) responses to vaccination with CSP(OVA_323-339) were quantified in mice (n = 4) pre-vaccinated with either PBS + TMG or OVA_323-339 + TMG using two-way ANOVA with Bonferroni’s post-test. …”

Example of activity space definition. by Simon Vonthron (8871875)

“…Combining measures of food exposure (residential area, activity space) presents a promising approach to understanding food environment dynamics. …”

Investigation of the Extraction Complexes of Light Lanthanides(III) with Bis(2,4,4-trimethylpentyl)dithiophosphinic Acid by EXAFS, IR, and MS in Comparison with the Americium(III)... by Tian Guoxin (2967663)

“…The coordination number of Ln(III) in the complexes is 8; the coordinated donor atoms are 7 sulfur atoms from 4 HBTMDTP molecules and 1 O atom from a hydrated water molecule. With the increase of the atomic number of Ln, the coordination bond lengths of Ln−O and Ln−S decrease in the complexes. …”

DataSheet_1_Methylation-mediated silencing of EDN3 promotes cervical cancer proliferation, migration and invasion.xlsx by Peng Zhu (277243)

“…EDN3 silencing mediated by methylation can be blocked by 5-Azacytidine (5-Aza), a DNA methyltransferase 1 (DNMT1) inhibitor, treatment in cervical cancer cell lines. …”

Data_Sheet_3_Coral-Derived Endophytic Fungal Product, Butyrolactone-I, Alleviates Lps Induced Intestinal Epithelial Cell Inflammatory Response Through TLR4/NF-κB and MAPK Signaling... by Shengwei Chen (1764178)

Image2_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Then, SZV-1287 (20 mg/kg/day) or its vehicle was injected intraperitoneally over a 21-day period.</p>Results<p>MIA induced remarkable weight bearing and paw withdrawal threshold decrease, alterations in the tibial and femoral structures (decreased trabeculation and cortical erosions), histopathological damage (disorganized cartilage structure, hypocellularity, decreased matrix staining, disrupted tidemark integrity, synovial hyperplasia, and osteophyte formation), and changes in the astrocyte and microglia density in the lumbar spinal cord.…”

Raw data of the participants. by Yasuaki Mushiga (21485741)

“…Serum low-density lipoprotein cholesterol (LDLC) levels showed a negative correlation with GCL volume (P = 0.005), and trends of negative correlations with retinal nerve fiber layer (RNFL) (P = 0.060) and NRL volumes (P = 0.051) in the control group. …”

Data_Sheet_1_Lactose-Induced Chronic Diarrhea Results From Abnormal Luminal Microbial Fermentation and Disorder of Ion Transport in the Colon.PDF by Hong Xue (28736)

“…The concentrations of lactose, galactose and lactic acid of the cecal content were markedly increased (P < 0.01) and SCFA concentration was significantly decreased (P < 0.01). This was associated with depletion of the Lachnospiraceae NK4A136 group and Ruminococcaceae UCG-005 and increased relative abundance of Lactobacillus, escherichia-shigella and megamonas in the cecal microbiota. …”

Table_1_Balancing Economic and Environmental Performance for Small-Scale Rice Farmers in Peru.DOCX by Marshal White (9582224)

“…Results from focus group discussions highlighted that rice production has changed in recent decades, and there is a need for improved extension support to cope with increasing pests, disease, and water scarcity. …”

Table_1_Vacuolar nitrate efflux requires multiple functional redundant nitrate transporter in Arabidopsis thaliana.XLSX by Yu-Ting Lu (8490249)

“…Further analysis showed that the sextuple mutant (npf5.10 npf5.14 npf8.5 npf5.11 npf5.12 npf5.16) had a higher ¹⁵NO3-uptake rate than the wild-type Col-0, but no significant difference was observed for nitrate accumulation between them. …”

Data_Sheet_2_Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment.ZIP by Faqi Wang (2072857)

“…This study adds to the evidence that LIFUS could become a promising and non-invasive treatment strategy for the clinical treatment of central nervous system diseases related to cognitive impairments in the future.…”

Image_2_The Global, Regional, and National Burden and Trends of Breast Cancer From 1990 to 2019: Results From the Global Burden of Disease Study 2019.tif by Shangbo Xu (10841163)

“…High social-development index (SDI) quintiles had the highest incidence cases with a declining trend in age-standardized incidence rate. …”

Image_1_Differential Action of Reelin on Oligomerization of ApoER2 and VLDL Receptor in HEK293 Cells Assessed by Time-Resolved Anisotropy and Fluorescence Lifetime Imaging Microsco... by Paula Dlugosz (6400175)

“…Details of this pathway are still not fully understood since the participating components are highly variable and create a complex mixture of interacting molecules. Reelin is proteolytically processed resulting in five different fragments some of which carrying the binding site for two different but highly homologous receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR). …”

Cardiac-Specific SOCS3 Deletion Prevents <i>In Vivo</i> Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules by Takanobu Nagata (745407)

“…Our findings suggest that SOCS3 may represent a key factor that exacerbates the development of myocardial IRI.…”

Image_2_Differential Action of Reelin on Oligomerization of ApoER2 and VLDL Receptor in HEK293 Cells Assessed by Time-Resolved Anisotropy and Fluorescence Lifetime Imaging Microsco... by Paula Dlugosz (6400175)

“…Details of this pathway are still not fully understood since the participating components are highly variable and create a complex mixture of interacting molecules. Reelin is proteolytically processed resulting in five different fragments some of which carrying the binding site for two different but highly homologous receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR). …”

Image_1_The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease.tif by Fangyan Wang (6410591)

“…In vitro, butyrate, not acetate or propionate, increased the expression of phosphatase MKP-1 to dephosphorylate activated JNK, ERK1/2 and p38 MAPK against excessive inflammation in RAW264.7 macrophages. It suggests a new insight into probiotics and their metabolites supplements to treat KD.…”

Table 1_Respiratory microbiome and metabolome features associate disease severity and the need for doxycycline treatment in children with macrolide-resistant Mycoplasma pneumoniae-... by Wei-Chao Liao (3574649)

“…F. periodonticum abundance was negatively associated with an inflammatory metabolite: a platelet-activating factor. Fusobacterium and Oribacterium were related to the decrease in LysoPE(18:1(9Z)/0:0) and LysoPC(18:1(9Z)).…”

Image3_BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate.TIF by Ruiqi Liu (3873832)

“…B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), one of spermatogonial stem cell markers, is a member of Polycomb repressive complex 1 (PRC1) and important to spermatogenesis. …”

Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination by Tatenda Kadungure (782562)

“…By retroviral transduction of mutant AID proteins into <i>aid</i>^<i>-/-</i> mouse splenic B cells, we show that 4 amino acids within the C terminus of mouse AID, when individually mutated to specific amino acids (R190K, A192K, L196S, F198S), reduce CSR about as much or more than deletion of the entire C terminal 10 amino acids. …”

Effects of local cardiac denervation on cardiac innervation and ventricular arrhythmia after chronic myocardial infarction by Xudong Liu (6899)

“…Our study suggests that this methodology might decrease malignant ventricular arrhythmia in chronic MI, and has a great potential for clinical application.…”