Rev-D4F decreased the expression of ICAM-1 and VCAM-1 in the arterial walls of C57BL/6J mice fed a high fat diet. by Yang Nana (799045)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

Supplementary file 1_Identifying early blood glucose trajectories in sepsis linked to distinct long-term outcomes: a K-means clustering study with external validation.docx by Huan Ma (713125)

“…Restricted cubic spline analysis demonstrated a U-shaped association for mean glucose levels and a J-shaped relationship for GV linked to 1-year mortality risks, while an optimal glycemic range of 122 to 160 mg/dL and GV less than 0.18 indicated improved survival.…”

AQP1 abundance. by Sophie Constantin Lütken (689916)

“…<i>A</i>) L-Sham was decreased vs. Sham and HF, as also presented in <i>B</i>) and <i>E</i>). …”

Gating strategy for flow cytometry. by Katie D. Pool (20141584)

Microplastics Influence Dissolved Organic Matter Transformation Mediated by Microbiomes in Soil Aggregates by Xinran Qiu (9182255)

“…The addition of MPs resulted in a decrease in the stability of DOM in large-sized aggregates but an increase in the aromaticity and unsaturation of DOM in small-sized aggregates, which were more pronounced in the PLAMPs-treated group. …”

AQP4 abundance. by Sophie Constantin Lütken (689916)

“…Immunoblot was reacted with anti-AQP4 antibody and reveals a single ~ 34.5 kDa AQP4-band (<i>A-E</i>). Data are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116501#pone.0116501.t010" target="_blank">Table 10</a>. …”

V2 vasopressin receptor abundance. by Sophie Constantin Lütken (689916)

“…Immunoblot was reacted against anti-V2R protein and revealed a single band at ~ 47 kDa (<i>A-E</i>). Data are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116501#pone.0116501.t005" target="_blank">Table 5</a>. …”

Dysregulation of miR-150-5p and its target FoxO3a in atherosclerosis (AS). by Ping-yu Cai (12389929)

Decreased intracellular replication of <i>S</i>. Typhimurium Δ<i>sucCD</i> and Δ<i>gltA</i> strains during infection of HeLa epithelial cells. by Steven D. Bowden (237943)

(Pro)renin receptor abundance. by Sophie Constantin Lütken (689916)

“…Immunoblot was reacted with a specific antibody against anti-(P)RR revealing a single band at ~ 42 kDa (<i>A-E</i>). …”

Type 1_A angiotensin II receptor abundance. by Sophie Constantin Lütken (689916)

“…(<i>A</i> and <i>B</i>) Analysis revealed significantly decreased AT1R expression in HF and L-HF vs. …”

Table_2_Transcutaneous Electrical Acupoint Stimulation Decreases the Incidence of Postoperative Nausea and Vomiting After Laparoscopic Non-gastrointestinal Surgery: A Multi-Center... by Wei Gao (2085)

“…Importance<p>Postoperative nausea and vomiting (PONV) gives patients a bad experience and negates their good recovery from surgery.…”

Table_1_Transcutaneous Electrical Acupoint Stimulation Decreases the Incidence of Postoperative Nausea and Vomiting After Laparoscopic Non-gastrointestinal Surgery: A Multi-Center... by Wei Gao (2085)

“…Importance<p>Postoperative nausea and vomiting (PONV) gives patients a bad experience and negates their good recovery from surgery.…”

Aβ and 22C11 agonist decreased cholesterol uptake whereas the sAPP-derived peptide and SM-ϕ stimulated increased cholesterol uptake by Caco-2 cells. by Kendra L. Puig (334788)

Gsα subunit abundance. by Sophie Constantin Lütken (689916)

Change in rectal temperature following pre-medication, induction and inhalant anesthesia. by Jacob P. Rastas (20642173)

“…Overall, when all time points and warming treatments were combined, ACE had significantly larger decreases in body temperature versus DEX, mainly attributable to significant differences at >T30 minutes (both P < 0.05). …”

Treatment with SEFA-6179 in mice receiving a high carbohydrate diet (HCD) with intravenous saline or SOLE decreases lipid metabolites involved in lipotoxicity including diacylglyce... by Bennet S. Cho (6944669)

There is decreased fluorescence from the <i>in planta</i> interaction between sYFPn-2b and sYFPc-AGO1 in the presence of the cucumber mosaic virus 1a protein. by Lewis G. Watt (9728094)