Temporal Patterns of Medications Dispensed to Children and Adolescents in a National Insured Population by Karen L. Olson (149953)

“…Contraceptives accounted for a large proportion of dispensed medication to older teenage girls. …”

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor by Renato Ferreira de Freitas (1399675)

“…Here, by deconstructing potent PRMT inhibitors, we find that chemical moieties occupying the substrate arginine-binding site can act as efficient fragment inhibitors. Screening a fragment library against PRMT6 produced numerous hits, including a 300 nM inhibitor (ligand efficiency of 0.56) that decreased global histone 3 arginine 2 methylation in cells, and can serve as a warhead for the development of PRMT chemical probes.…”

Blockade of GKAP degradation prevents Aβ-induced actin cytoskeleton remodeling. by Francesco Roselli (211670)

“…Likewise, Aβ caused a marked decrease in F-actin accumulation in spines (61.5±6.7% of control, p<0.05), whereas roscovitine pre-treatment largely blocked this effect (90.0±15.1%, Rosco+Aβ vs Aβ alone). …”

Buckling and Torsional Instabilities of a Nanoscale Biological Rope Bound to an Elastic Substrate by Chris Peacock (9437559)

“…In addition, in ambient conditions, the sine wave response coexists with the formation of loops along the length of the fibrils, as observed for the torsional instability of a twisted filament when tension is decreased. This work provides direct evidence that single collagen fibrils are highly susceptible to axial compression because of their helical supermolecular structure. …”

Safety profiles of tetracycline-class drugs: a pharmacovigilance analysis of the FAERS database by Xu Zhang (49484)

“…However, the safety of third-generation tetracycline in children requires additional validation through a large-scale prospective study.</p>…”

Implementation and first experiences with a multimodal mentorship curriculum for medicine-paediatrics residents by Lao-Tzu Allan-Blitz (12073783)

“…Future work is needed using more objective outcome markers among a larger and more diverse group of residents. KEY MESSAGES</p><p>Among resident physicians in a single training program, a mix of mentor–mentee dyads, group-based peer mentoring and a structured curriculum has shown promise in improving resident-reported satisfaction with programmatic mentorship</p><p>While we attempted to adapt the mentorship curriculum to an online platform with the development of the SARS-CoV-2 pandemic, reported satisfaction in overall mentorship and emotional support decreased in comparison to the prior year, an important focus for future work.…”

Serotonin modulates L2 neuron visually induced calcium transient kinetics. by Maureen M. Sampson (9322886)

“…(<b>D</b>) Response to light flashes. When a light flash was presented in control experiments, L2 cells responded with a decrease in GCaMP signal followed by a large sustained increase in the GCaMP6 signal. …”

SSD - a free software for designing multimeric mono-, bi- and trivalent shRNAs by Gabriel José de Carli (8526942)

“…RT-qPCR analysis revealed that our molecule promoted a decrease in more than 50% of the target mRNA, in a dose-dependent manner, when compared to the control group. …”

Catalytic Conversion of a Chitin-Derived Sugar Alcohol to an Amide-Containing Isosorbide Analog by Takuya Sagawa (4996418)

“…Instead, a large amount of a super strong acid, CF₃SO₃H, under vacuum conditions is required to produce ADI from ADS. …”

Single-Component Conductors: A Sturdy Electronic Structure Generated by Bulky Substituents by Agathe Filatre-Furcate (1762963)

“…This system is weakly conducting at ambient pressure (5 S·cm^–1), and both transport and optical measurements evidence a slowly decreasing energy gap under applied pressure with a regime change around 1.5 GPa. …”

Single-Metallic Thermoresponsive Coordination Network as a Dual-Parametric Luminescent Thermometer by Kedar Bahadur Thapa (11166857)

“…The single-metallic coordination networks (CNs), simultaneously exhibiting temperature-dependent lifetime (TDLT) and emission band shift (TDEBS), are desirable for application in luminescent thermometers with high accuracy and reliability in a large temperature range. Nonetheless, up to date, there are no reports on such kinds of materials due to the lack of in-depth understanding of the origin of TDLT and TDEBS at a molecule level, being critical for exploiting a universal approach to design a dual-parametric CN phosphorescent thermometer (CN-PT). …”

Illustration of three simple scenarios of association between genotype and a bivariate phenotype. by Matthew Stephens (3815)

“…Each point represents an individual, colored according to their genotype (0, 1 or 2 copies of the minor allele). A) A variant associated with <i>weight</i> but not <i>height</i>. …”

Single-Metallic Thermoresponsive Coordination Network as a Dual-Parametric Luminescent Thermometer by Kedar Bahadur Thapa (11166857)

“…The single-metallic coordination networks (CNs), simultaneously exhibiting temperature-dependent lifetime (TDLT) and emission band shift (TDEBS), are desirable for application in luminescent thermometers with high accuracy and reliability in a large temperature range. Nonetheless, up to date, there are no reports on such kinds of materials due to the lack of in-depth understanding of the origin of TDLT and TDEBS at a molecule level, being critical for exploiting a universal approach to design a dual-parametric CN phosphorescent thermometer (CN-PT). …”

A Mechanistic Beta-Binomial Probability Model for mRNA Sequencing Data by Gregory R. Smith (3165048)

“…The so-called dispersion parameter controls this scaling, and our analysis suggests that the dispersion parameter is a continually decreasing function of the mean, as opposed to current approaches that impose an asymptotic value to the dispersion parameter at moderate mean read counts. …”

Single-Metallic Thermoresponsive Coordination Network as a Dual-Parametric Luminescent Thermometer by Kedar Bahadur Thapa (11166857)

“…The single-metallic coordination networks (CNs), simultaneously exhibiting temperature-dependent lifetime (TDLT) and emission band shift (TDEBS), are desirable for application in luminescent thermometers with high accuracy and reliability in a large temperature range. Nonetheless, up to date, there are no reports on such kinds of materials due to the lack of in-depth understanding of the origin of TDLT and TDEBS at a molecule level, being critical for exploiting a universal approach to design a dual-parametric CN phosphorescent thermometer (CN-PT). …”

A Chromosome-Level Reference Genome Assembly and Evolution of Dongxiang Wild Rice by chunxiu shen (8944760)

“…Compared with other Oryza species, the genes related to disease and cold resistance in DXWR had undergone a large-scale expansion, which may be one of the reasons for the stronger disease resistance and cold resistance of DXWR. …”

Single-Metallic Thermoresponsive Coordination Network as a Dual-Parametric Luminescent Thermometer by Kedar Bahadur Thapa (11166857)

“…The single-metallic coordination networks (CNs), simultaneously exhibiting temperature-dependent lifetime (TDLT) and emission band shift (TDEBS), are desirable for application in luminescent thermometers with high accuracy and reliability in a large temperature range. Nonetheless, up to date, there are no reports on such kinds of materials due to the lack of in-depth understanding of the origin of TDLT and TDEBS at a molecule level, being critical for exploiting a universal approach to design a dual-parametric CN phosphorescent thermometer (CN-PT). …”

CKD273, a New Proteomics Classifier Assessing CKD and Its Prognosis by Àngel Argilés (3720442)

“…The CKD273 classifier separated CKD patients according to their renal function and informed on the likelihood of experiencing adverse outcome. Recently defined in a large population, CKD273 is the first proteomic-based classifier successfully tested for prognosis of CKD progression in an independent cohort.…”

Image_5_The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer.TIFF by Xin-Yi Tang (9031154)

“…X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. …”

Table_2_The Circumferential Resection Margin Is a Prognostic Predictor in Colon Cancer.docx by Xin-Yi Tang (9031154)

“…X-tile software identified 0 and 30 mm as optimal cutoff values (P < 0.001) for prognosis, which was applicable only in stage II–IV patients. A 20 and 33% risk decrease were observed in patients with CRM between 0 and 30 mm [95% confidence interval (CI) = 0.76–0.84], and larger than 30 mm (95% CI = 0.62–0.71), respectively. …”