Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment by Adam A. Friedman (812702)

“…We describe the results of a combination screen of an unprecedented scale in mammalian cells performed using a collection of targeted, clinically tractable agents across a large panel of melanoma cell lines. …”

Data_Sheet_1_Associations of lipids and lipid-lowering drugs with risk of stroke: a Mendelian randomization study.ZIP by Hao Qin (113159)

“…The IVW-MR also found a suggestive evidence that decreased LDL-C levels mediated by the PCSK9 (proprotein convertase subtilisin-kexin type 9) gene were associated with a reduced risk of any stroke (AS) (OR, 1.31; 95% CI, 1.13–1.52; p = 0.0003), any ischemic stroke (AIS) (OR, 1.29; 95% CI, 1.10–1.51; p = 0.001), and LAS (OR, 1.73; 95% CI, 1.15–2.59; p = 0.008), while NPC1L1 (Niemann-Pick C1-like protein)-mediated LDL-C levels were associated with a higher risk of small vessel stroke (SVS) (OR, 6.10; 95% CI, 2.13–17.43; p = 0.0008). …”

Table1_The role of circulating cytokines in heart failure: a bidirectional, two-sample Mendelian randomization study.xlsx by Haoran Zheng (388894)

“…This study draws further conclusions at the genetic level, providing a basis for future large-scale clinical trials.…”

Datasheet1_The role of circulating cytokines in heart failure: a bidirectional, two-sample Mendelian randomization study.pdf by Haoran Zheng (388894)

“…This study draws further conclusions at the genetic level, providing a basis for future large-scale clinical trials.…”

DataSheet_1_Cascading effects of seed-stem-individual spatial patterns along a grazing gradient.docx by Zhou Qin-Yuan (14792533)

“…The results showed the following: (1) Seed size increased with increasing grazing intensity, and the coefficient of variation for seed size and seed number in the heavy grazing treatment was greater than 0.6. (2) The structural equation model showed that grazing treatment had a positive effect on seed number, seed size and reproductive stem number and a negative effect on reproductive stem weight. (3) Grazing treatment did not affect the resource allocation to reproductive stems and vegetative stems per unit length of reproductive K. humilis individuals. (4) Compared with the number of reproductive individuals in the no grazing treatment, the number in the heavy grazing treatment decreased significantly, and the negative correlation between reproductive individuals and nonreproductive individuals changed from a full-scale negative correlation to a small-scale negative correlation and a large-scale positive correlation. …”

Data Sheet 1_Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study.docx by Yi Kang (387134)

“…Background<p>Evidence indicates a negative link between glucosamine and age-related cognitive decline and sarcopenia. …”

Table_2_Neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced rectal cancer: A new era for anal preservation.xlsx by Yaqi Wang (1555240)

“…It was demonstrated to decrease the local recurrence rate and increase the tumor response grade. …”

Table_1_Oxidative balance score: a potential tool for reducing the risk of colorectal cancer and its subsites incidences.docx by Yu Chang (392011)

“…The objective of this study was to assess the relationship between OBS and the risk of CRC, its subsites, and common complications in a large prospective cohort study.</p>Methods<p>We included data from 175,808 participants in the UK Biobank data sample repository from 2006 to 2010. …”

Table_1_Neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced rectal cancer: A new era for anal preservation.xlsx by Yaqi Wang (1555240)

“…It was demonstrated to decrease the local recurrence rate and increase the tumor response grade. …”

DataSheet_1_The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study.docx by Jian Kang (118630)

“…</p>Results<p>The results showed that a 1 standard deviation(SD) increase in HDL-C, LDL-C and TC was associated with a decrease in LS-BMD of 0.039 g/cm², 0.045 g/cm² and 0.054 g/cm², respectively. …”

DataSheet_2_The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study.xlsx by Jian Kang (118630)

“…</p>Results<p>The results showed that a 1 standard deviation(SD) increase in HDL-C, LDL-C and TC was associated with a decrease in LS-BMD of 0.039 g/cm², 0.045 g/cm² and 0.054 g/cm², respectively. …”

Presentation_1_Contrasting Effects of Long-Term Nitrogen Deposition on Plant Phosphorus in a Northern Boreal Forest.pdf by Kristin Palmqvist (3140016)

“…We therefore conclude that increased NP ratio of vegetation cannot be used as a sole indicator of P limitation. The vegetation and O-horizon changes in N2 were still large enough to merit further studies addressing whether such high N loads may alter ecosystem biogeochemistry toward P limitation. …”

The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study by Donald A. Belcher (4836420)

“…In addition, we found that PolyhHb transfusion decreased the wall shear stress at large arteriole diameters (>20 μm), but increased wall shear stress for small arteriole diameters (<10 μm). …”

Table 1_Assessment of brain atrophy as a promising marker of radiological activity in patients with relapsing–remitting multiple sclerosis.docx by Aleksandra Pogoda-Wesołowska (14589242)

“…In the year-to-year analysis (n_CLAD = 59, n_ALEM = 36) within the CLAD group, new T2 lesions were significantly associated with a decrease in thalamic (p = 0.02), cerebellum (p = 0.05) and deep grey matter (p = 0.05) volume. …”

Conservation in a changing world: assessing the conservation status of an agruculturally adapted species, the Blue Crane. Chapter 2: Population Trends by Christie Craig (21008186)

“…Continued CAR counts will be important to ascertain whether the population has stabilised at a lower density or is continuing to decrease. In winter, Blue Cranes select for pastures (especially lucerne and lupin fields) in the Karoo and Western Cape wheatlands. …”

DataSheet_1_Breast microbiome associations with breast tumor characteristics and neoadjuvant chemotherapy: A case-control study.docx by Xuejun Li (133209)

Table_4_Associations between nutritional and immune status and clinicopathologic factors in patients with tuberculosis: A comprehensive analysis.xlsx by Quan-Xian Liu (14167029)

“…In multivariate logistic regression analysis, weight loss (OR: 0.209, 95% CI: 0.060-0.722; p =0.013) was significantly associated with higher nutritional risk (NRS 2002≥3). In multiple linear regression analysis, the NRS 2002 score was higher (B=2.018; p =0.023), and extrapulmonary tuberculosis (B=-6.205; p =0.007) was linked with a longer duration of hos-pitalization.…”

Table_3_Associations between nutritional and immune status and clinicopathologic factors in patients with tuberculosis: A comprehensive analysis.xlsx by Quan-Xian Liu (14167029)

“…In multivariate logistic regression analysis, weight loss (OR: 0.209, 95% CI: 0.060-0.722; p =0.013) was significantly associated with higher nutritional risk (NRS 2002≥3). In multiple linear regression analysis, the NRS 2002 score was higher (B=2.018; p =0.023), and extrapulmonary tuberculosis (B=-6.205; p =0.007) was linked with a longer duration of hos-pitalization.…”

Table_5_Associations between nutritional and immune status and clinicopathologic factors in patients with tuberculosis: A comprehensive analysis.xlsx by Quan-Xian Liu (14167029)

“…In multivariate logistic regression analysis, weight loss (OR: 0.209, 95% CI: 0.060-0.722; p =0.013) was significantly associated with higher nutritional risk (NRS 2002≥3). In multiple linear regression analysis, the NRS 2002 score was higher (B=2.018; p =0.023), and extrapulmonary tuberculosis (B=-6.205; p =0.007) was linked with a longer duration of hos-pitalization.…”

Table_6_Associations between nutritional and immune status and clinicopathologic factors in patients with tuberculosis: A comprehensive analysis.xlsx by Quan-Xian Liu (14167029)

“…In multivariate logistic regression analysis, weight loss (OR: 0.209, 95% CI: 0.060-0.722; p =0.013) was significantly associated with higher nutritional risk (NRS 2002≥3). In multiple linear regression analysis, the NRS 2002 score was higher (B=2.018; p =0.023), and extrapulmonary tuberculosis (B=-6.205; p =0.007) was linked with a longer duration of hos-pitalization.…”