Image1_Blockade of prostaglandin E2 receptor 4 ameliorates peritoneal dialysis-associated peritoneal fibrosis.pdf by Qimei Luo (4732002)

“…To further investigate the functional role of EP4, ONO-AE3-208 was administrated for 4 weeks in a rat model of PD, the results of which showed that ONO-AE3-208 inhibited peritoneal fibrosis and improved peritoneal dysfunction. …”

Transfusion: -80°C Frozen Blood Products Are Safe and Effective in Military Casualty Care by Femke Noorman (3396926)

“…</p><p>Materials and Methods</p><p>Hemovigilance and combat casualties data from Afghanistan 2006–2010 for 272 (military) trauma casualties with or without massive transfusions (MT: ≥6 RBC/24hr, N = 82 and non-MT: 1–5 RBC/24hr, N = 190) were analyzed retrospectively. In November 2007, a massive transfusion protocol (MTP; 4:3:1 RBC:Plasma:Platelets) for ATLS^® class III/IV hemorrhage was introduced in military theatre. …”

DataSheet_1_GhWRKY70D13 Regulates Resistance to Verticillium dahliae in Cotton Through the Ethylene and Jasmonic Acid Signaling Pathways.pdf by Xian-Peng Xiong (8615040)

“…<p>Verticillium wilt caused by Verticillium dahliae is a destructive cotton disease causing severe yield and quality losses worldwide. …”

Data_Sheet_3_Comparison of Calcium Balancing Strategies During Hypothermic Acclimation of Tilapia (Oreochromis mossambicus) and Goldfish (Carassius auratus).PDF by Tsung-Yu Han (5710796)

“…This difference can be attributed to alterations in the transportation parameters for Ca²⁺ influx, i.e., maximum velocity (V_max) and binding affinity (1/K_m). There was also a significant difference in the regulation of Ca²⁺ efflux between the two fishes. …”

Image 4_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…<p>Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. …”

Image_1_Identification and validation of key molecules associated with humoral immune modulation in Parkinson’s disease based on bioinformatics.tif by Na Xing (823501)

“…</p>Methods<p>Firstly, we performed a series of bioinformatic analyses utilizing the expression profile of the peripheral blood mononuclear cell (PBMC) obtained from the GEO database (GSE100054, GSE49126, and GSE22491) to identify differentially expressed genes related to humoral immune regulatory mechanisms between PD and healthy controls. …”

T follicular helper cells regulate the activation of B lymphocytes and antibody production during <i>Plasmodium vivax</i> infection by Maria Marta Figueiredo (338454)

“…<i>vivax</i>) infection and if they play a role during disease remains unknown. Our goal was to define the role of Tfh cells during <i>P</i>. …”

Image_4_An in vitro Model of Human Retinal Detachment Reveals Successive Death Pathway Activations.tif by Jelena Potic (9693587)

“…Almost no Cleaved-Caspase3 signal was observed, whereas a transient augmentation at day 3 of AIF-positive cells was observed to be about 10-fold in comparison to the control group (n = 2). …”

Alteration of mRNA abundance, oxidation products and antioxidant enzyme activities during oocyte ageing in common carp <i>Cyprinus carpio</i> by Azin Mohagheghi Samarin (6392774)

“…The lack of response of both activities of antioxidant enzymes and oxidation products during oocyte ageing strengthens the conclusion that oxidative stress is unlikely to be a main factor determining the progress of oocyte ageing in common carp. …”

Data_Sheet_2_Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D-Galactose-Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota... by Baiyan Liu (12869393)

“…Liuwei Dihuang decoction (LW), a commonly applied Chinese medicine formula, is widely used for the treatment of aging-related diseases in China. …”

Data_Sheet_2_Single-cell transcriptome revealed dysregulated RNA-binding protein expression patterns and functions in human ankylosing spondylitis.docx by Zheng Ren (1766506)

“…</p>Results<p>(1) Compared with the HC group, the numbers of B, DC (dendritic cells), CD14⁺ Mono and CD8⁺ T cells were increased in AS group, while the numbers of platelet (platelets), CD8⁺ NKT, CD16⁺ Mono (non-classical monocytes), Native CD4⁺ T and NK were decreased. (2) Through the analysis of RBP genes in B cells, some RBPs were found to play an important role in B cell differentiation and function, such as DDX3X, SFPQ, SRRM1, UPF2. (3) It may be related to B-cell receptor, IgA immunity, NOD-like receptor and other signaling pathways; Through the analysis of RBP genes in CD8⁺ T cells, some RBPs that play an important role in the immune regulation of CD8⁺ T were found, such as EIF2S3, EIF4B, HSPA5, MSL3, PABPC1 and SRSF7; It may be related to T cell receptor, TNF, IL17 and other signaling pathways. (4) Based on bulk RNA-seq, it was found that compared with HC and AS patients, differentially expressed variable splicing genes (RASGs) may play an important role in the occurrence and development of AS by participating in transcriptional regulation, protein phosphorylation and ubiquitination, DNA replication, angiogenesis, intracellular signal transduction and other related pathways.…”

Table_6_Antioxidant Activity and the Potential Mechanism of the Fruit From Ailanthus altissima Swingle.XLSX by Ya-nan Mo (11829002)

“…<p>The fruits of Ailanthus altissima Swingle (AS) possess a variety of pharmacological activities. Its antioxidant activity and the potential mode of action have not yet been investigated. …”

DataSheet_1_AURKA inhibitor-induced PD-L1 upregulation impairs antitumor immune responses.docx by Bi Meng (16970205)

“…</p>Results<p>We found that AURKA inhibitor MLN8237 promoted the expression of PD-L1 in a time- and concentration-dependent manner while exerted its antitumor effect. …”

Image_2_Effects of Intranasal Oxytocin on Pup Deprivation-Evoked Aberrant Maternal Behavior and Hypogalactia in Rat Dams and the Underlying Mechanisms.jpg by Xiao Yu Liu (1264464)

“…<p>Oxytocin (OT), a hypothalamic neuropeptide, applied through nasal approach (IAO), could improve maternal health during lactation that is disrupted by mother–baby separation; however, the regulation of IAO effects on maternal behaviors and lactation as well as the underlying mechanisms remain unclear. …”

Table_1_METH-Induced Neurotoxicity Is Alleviated by Lactulose Pretreatment Through Suppressing Oxidative Stress and Neuroinflammation in Rat Striatum.docx by Xiao-Li Xie (5922641)

“…<p>Abuse of methamphetamine (METH) results in neurological and psychiatric abnormalities. Lactulose is a poorly absorbed derivative of lactose and can effectively alleviate METH-induced neurotoxicity in rats. …”

Table_1_Global, regional, and national years lived with disability due to blindness and vision loss from 1990 to 2019: Findings from the Global Burden of Disease Study 2019.docx by Shasha Li (139491)

“…Purpose<p>This study aimed to provide a comprehensive assessment of burden estimates and the secular trend of blindness and vision loss, as measured by years lived with disability (YLDs), at the global, regional, and national levels.…”

DataSheet1_Thermodynamics and Kinetics of pH-dependent Dissolution of Sparingly Soluble Alkaline Earth Hydroxides in Source-Separated Human Urine Collected in Decentralised Sanitat... by Prithvi Simha (9366341)

“…Within the emerging niche of source-separating sanitation, these chemicals have found a new application—to prevent urease-catalysed degradation of urea present in freshly excreted human urine. …”

Data_Sheet_1_IL-6 and IL-8 Are Linked With Myeloid-Derived Suppressor Cell Accumulation and Correlate With Poor Clinical Outcomes in Melanoma Patients.pdf by Richard P. Tobin (7840187)

SDC4 controls the activity of Tiam1. by Aniko Keller-Pinter (4582792)

“…<p>(A) Schematic representation of SDC4 clones. The Ser179 of the cytoplasmic domain of SDC4 was mutated to non-phosphorylatable Ala (Ser179Ala) or, phosphomimetic Glu (Ser179Glu), respectively. …”

Image_5_Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI.png by Neftali Ramirez (13251924)

“…In steady state, naïve B cells had increased cell death pathways and reduced cell metabolism pathways, while after stimulation, enhanced immune responses and decreased cell survival were detected. Using a multi-omics approach, our findings provide valuable insights into the impaired biology of naïve B cells from TACI mutation carriers.…”