Targeted knockdown of p63γ variants decreased the mRNA expression of VDR, osterix, runx2 and osteopontin. by Kevin M. Curtis (718103)

Expression of members of Wnt and BMP2 signaling pathways decreased, while SOST increased, in alveolar bone in response to HFA. by Mani Alikhani (5180768)

Serum starvation increases the expression level and prolongs the decay rate of GAS5, and decreases the expression of glucocorticoid-responsive genes. by Hidenori Tani (169942)

STAT5 protein is decreased and STAT3 protein is nuclear localized in H1N1+ Mammary Glands. by Stéphane G. Paquette (5649400)

IL-17 neutralization reduces serum CTx level in Ovx mice and decreases RANKL expression in femur trabecular bone. by Abdul M. Tyagi (137574)

Chronic EtOH drinking decreases hippocampal neurotrophin levels only in adult onset EtOH drinking rats. by Gina M. Fernandez (2547475)

DataSheet_2_Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer.pdf by Hannah Shailes (12698270)

“…Mechanistically, our data reveals this new synthetic lethal relationship is a consequence of decreased Wnt signalling and, ultimately, a reduction in the level of expression of the anti-apoptotic protein Survivin, upon statin treatment in the APC-mutant cells only. …”

DataSheet_1_DNA N6-Methyladenine (6mA) Modification Regulates Drug Resistance in Triple Negative Breast Cancer.pdf by Xianneng Sheng (10076839)

“…Meanwhile, compared with normal tissues, the expression level of 6mA and its methylase N6AMT1 was significantly decreased in TNBC tissue. …”

Table_3_Vitamin A deficiency in the MENA region: a 30-year analysis (1990–2019).DOCX by Saeid Safiri (3713035)

“…Background<p>Vitamin A deficiency (VAD) is a common micronutrient deficiency that imposes a substantial burden worldwide. …”

DataSheet_1_Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer.pdf by Hannah Shailes (12698270)

“…Mechanistically, our data reveals this new synthetic lethal relationship is a consequence of decreased Wnt signalling and, ultimately, a reduction in the level of expression of the anti-apoptotic protein Survivin, upon statin treatment in the APC-mutant cells only. …”

NMR Structure of a Cyclic Polyamide−DNA Complex by Qing Zhang (1802)

“…The solution structure of a cyclic polyamide ligand complexed to a DNA oligomer, derived from NMR restrained molecular mechanics, is presented. …”

Novel η¹-N,η²-C,C-Binding Mode between Pyridinyl-Functionalized Cyclopentadienyl Ligands and Iridium^† by Alex S. Ionkin (2040658)

“…The reaction between 2-(2,3,4,5-tetramethyl-cyclopenta-1,3-dienyl)-pyridine <b>1</b> and IrCl₃ was performed in an attempt to synthesize a cyclometalated system with decreased π conjugation in the ligand. …”

Table_2_Vitamin A deficiency in the MENA region: a 30-year analysis (1990–2019).DOCX by Saeid Safiri (3713035)

“…Background<p>Vitamin A deficiency (VAD) is a common micronutrient deficiency that imposes a substantial burden worldwide. …”

Maduramicin Inhibits Proliferation and Induces Apoptosis in Myoblast Cells by Xin Chen (14149)

“…Concurrently, maduramicin downregulated protein expression of cyclin D1, cyclin-dependent kinases (CDK4 and CDK6), and CDC25A, and upregulated expression of the CDK inhibitors (p21^Cip1 and p27^Kip1), resulting in decreased phosphorylation of Rb. …”

The Mitochondrial Unfolded Protein Response Protects against Anoxia in <i>Caenorhabditis elegans</i> by Salvador Peña (3147126)

“…“remote”) effects, we found that restricted activation of the UPR^mt in neurons decreased A-R death. However, expression of the <i>atfs-1(gf)</i> mutant in neurons, which resulted in a robust activation of a neuronal UPR^mt, did not upregulate the UPR^mt in distal tissues, nor did it protect the worms from A-R toxicity. …”

Table_1_Vitamin A deficiency in the MENA region: a 30-year analysis (1990–2019).DOCX by Saeid Safiri (3713035)

“…Background<p>Vitamin A deficiency (VAD) is a common micronutrient deficiency that imposes a substantial burden worldwide. …”

Supplemental Figure 1 from BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume by Nicholas Theodosakis (3466673)

Characterization of recent and minimally passaged Brazilian dengue viruses inducing robust infection in rhesus macaques by Maria Beatriz Borges (5142965)

“…Consistent with observations in humans, increased MCP-1, IFN-γ and VEGF-A levels, and transiently decreased IL-8 levels were detected after infection with the selected isolates. …”

Combined loss of Neurog1 and Neurod4 function disrupts habenular neurogenesis. by Caroline Halluin (3158562)

“…The expression of <i>cxcr4b</i> and <i>brn3a</i> appears unaffected in <i>neurod4</i> morpholino injected embryos (C, n = 13/13 and G, n = 14/15) as compared with the expression in wild type (A, n = 9/9 and E, n = 9/9); <i>cxcr4b</i> and <i>brn3a</i> expression is also unaffected in <i>neurog1</i>^{<i>hi1059</i>} mutant (B, n = 12/14 and F, n = 9/11) or only slightly decreased in few cases (respectively n = 2/14 and n = 2/11; data not shown). …”

Image_1_Hydrogen Peroxide Affects Growth of S. aureus Through Downregulation of Genes Involved in Pyrimidine Biosynthesis.tif by Hélène Buvelot (11401058)

“…Our results raise the possibility that ROS-dependent downregulation of pyrimidine metabolism might be a survival strategy of S. aureus, allowing colonization through intracellular survival, while decreasing the risk of killing the host through dampened extracellular growth.…”