A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages by Connor G. G. Bamford (5849141)

“…Counter-intuitively, expression of one member of the family, IFNλ4, is associated with decreased clearance of hepatitis C virus (HCV) in the human population; by contrast, a natural frameshift mutation that abrogates IFNλ4 production improves HCV clearance. …”

A canonical Hh signaling pathway is required to control NB proliferation but not neuronal differentiation. by Phing Chian Chai (382425)

“…<p>(A–I′) NB clones of different genotypes: <i>wt</i> (A–A′, D–D′, and G–G′), <i>ptc^S2</i> (B–B′, E–E′, and H–H′) and <i>smo^IA3</i> (C–C′, F–F′, and I–I′) were marked by CD8:GFP (green). …”

Tryptophan end-tagging confers antifungal activity to a tick-derived antimicrobial peptide by Court Chiramba (19114972)

“…Although reduced, Os-C(W₅) retains some antibiofilm activity in RPMI-1640 supplemented with 50% foetal bovine serum and in a synthetic wound medium.</p><p dir="ltr">In conclusion, this study demonstrates that tryptophan end-tagging is a simple modification that transforms a salt-sensitive AMP (Os-C) into a peptide (Os-C(W₅)) with antifungal activity in physiologically relevant environments.…”

(A, B) The processes of DNA synthesis and maintenance of insulin content do not occur simultaneously. by Nidhi Rohatgi (409215)

“…<p>Human islets were cultured in cCMRL, 5 or 8 mM glucose with or without the concentrations of MSDC-0160 and IGF-1 for 4 days as indicated. (<b>A</b>) Islet insulin content was measured from 20 islets in duplicate at the start of the incubation period (time-0) and after 4 days of incubation under the conditions shown at the bottom of the figure. …”

A simplified model to test the hypothesis that strain rate triggers cellular directional response. by Assaf Zaritsky (137666)

“…(<b>B</b>) Strain rate triggers a directional response (model calculation). Calculated ratio of the directional velocity parallel (<i>V_∥</i>) to the directional velocity toward The wound (<i>V₊</i>) as the acceleration wave propagates, for increasing sharpness of the wave (decreasing σ in Supporting <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003747#pcbi.1003747.s001" target="_blank">Text S1</a>), corresponding to a wave that is either sharper or with same σ but with larger overall peak acceleration leading to higher final velocity. …”

Primary Testing Methods: (a) MICP-based saline soil reinforcement apparatus; (b) Freeze-thaw conditioning chamber and single-cycle freeze-thaw protocol; (c) Consolidated undrained... by Liang Xiong (1426411)

Hysteretic Spin Crossover between a Bisdithiazolyl Radical and Its Hypervalent σ-Dimer by Kristina Lekin (1301844)

“…The value of σ_RT for β-<b>1a</b> (near 10⁻⁴ S cm⁻¹ at 0.5 GPa) initially decreases with pressure as the phase change takes place, but beyond 1.5 GPa this trend reverses, and σ_RT increases in a manner which parallels the behavior of α-<b>1a</b>. …”

Hysteretic Spin Crossover between a Bisdithiazolyl Radical and Its Hypervalent σ-Dimer by Kristina Lekin (1301844)

“…The value of σ_RT for β-<b>1a</b> (near 10⁻⁴ S cm⁻¹ at 0.5 GPa) initially decreases with pressure as the phase change takes place, but beyond 1.5 GPa this trend reverses, and σ_RT increases in a manner which parallels the behavior of α-<b>1a</b>. …”

Hysteretic Spin Crossover between a Bisdithiazolyl Radical and Its Hypervalent σ-Dimer by Kristina Lekin (1301844)

“…The value of σ_RT for β-<b>1a</b> (near 10⁻⁴ S cm⁻¹ at 0.5 GPa) initially decreases with pressure as the phase change takes place, but beyond 1.5 GPa this trend reverses, and σ_RT increases in a manner which parallels the behavior of α-<b>1a</b>. …”

Hysteretic Spin Crossover between a Bisdithiazolyl Radical and Its Hypervalent σ-Dimer by Kristina Lekin (1301844)

“…The value of σ_RT for β-<b>1a</b> (near 10⁻⁴ S cm⁻¹ at 0.5 GPa) initially decreases with pressure as the phase change takes place, but beyond 1.5 GPa this trend reverses, and σ_RT increases in a manner which parallels the behavior of α-<b>1a</b>. …”

Hysteretic Spin Crossover between a Bisdithiazolyl Radical and Its Hypervalent σ-Dimer by Kristina Lekin (1301844)

“…The value of σ_RT for β-<b>1a</b> (near 10⁻⁴ S cm⁻¹ at 0.5 GPa) initially decreases with pressure as the phase change takes place, but beyond 1.5 GPa this trend reverses, and σ_RT increases in a manner which parallels the behavior of α-<b>1a</b>. …”

Fluorescence time-lapse imaging of a single GPR3-HT-expressing CGN. by Tatsuhiro Miyagi (847543)

“…<p>(A-B) The CGNs were transfected with the pGPR3-HT expression vector and were plated onto 0.03% PEI-coated plates. …”

RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study by Pin Wang (300672)

“…</p><p>Results</p><p>The MCI group exhibited a decreased sRAGE level (0.87±0.35 vs. 1.05±0.52 ng/ml, <i>p</i><0.01) and an increased serum AGE-P level (3.54±1.27 vs. 2.71±1.18 U/ml, <i>p<</i>0.01) compared with the control group. …”

Isostructural Potassium and Thallium Salts of Sterically Crowded Triazenes: A Structural and Computational Study by Hyui Sul Lee (2324752)

“…In the solid-state structures of monomeric <b>2a</b> and <b>3a</b>, quasi-monomeric <b>2b</b>, <b>3b</b>, <b>2c</b>, and <b>3c</b>, and dimeric <b>2d</b> and <b>3d</b> additional metal-η^<i>n</i>-π-arene-interactions to the flanking arms of the biphenyl- and terphenyl groups in the triazenide ligands of decreasing hapticity <i>n</i> are observed. …”

Several VPS-II genes are upregulated in a Δ<i>zur</i> mutant. by Shannon G. Murphy (11001965)

“…<p><b>(A)</b> A predicted Zur-binding site (<u>TGTTAT</u>GTT<u>ATAACA</u>) located approximately 200 bp upstream of the <i>verA</i> open reading frame was aligned with the <i>Vibrionacae</i> Zur binding consensus sequence [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009624#pgen.1009624.ref035" target="_blank">35</a>]. …”

Prenatal medication use in a prospective pregnancy cohort by pre-pregnancy obesity status by Yassaman Vafai (10294851)

“…A total of 17 classes of medications were identified. …”

Incidence dynamics and investigation of key interventions in a dengue outbreak in Ningbo City, China by Bo Yi (2530183)

“…</p><p>Methods</p><p>Data of a dengue outbreak were collected in Ningbo City in China by a field epidemiological survey according to a strict protocol and case definition. …”

Zipf’s diagram showing the visitation frequency (<i>f</i>_<i>r</i>) to the r-th most visited location of a user who is stationary and works as a taxi driver. by Marcelina Łoś (11266764)

“…<p>A person who is stationary (orange dots) has higher (<i>f</i>_<i>r</i>) at the first and second most visited places and for further places (<i>f</i>_<i>r</i>) decreases significantly. …”

a, b, c, d and e: Mitochondrial DNA copy number based on real-time PCR of cytochrome B/18S levels from kidney (3a) after <i>S. aureus</i> infection. by Raquel R. Bartz (591550)

DataSheet1_Associations Between Asthma Diagnosis/Asthma Exacerbation and Previous Proton-Pump Inhibitor use: A Nested Case-Control Study Using a National Health Screening Cohort.do... by Hyo Geun Choi (7405439)

“…In contrast, overall PPI use decreased the risk of AE in participants with asthma (aOR = 0.79, 95% CI = 0.75–0.84, p < 0.001), although this effect was observed only for second-generation PPIs (aOR = 0.76, 95% CI = 0.65–0.89, p = 0.001).…”