Video_1_Functional Mobility Training With a Powered Knee and Ankle Prosthesis.MP4 by Suzanne B. Finucane (12394894)

“…<p>Limb loss at the transfemoral or knee disarticulation level results in a significant decrease in mobility. Powered lower limb prostheses have the potential to provide increased functional mobility and return individuals to activities of daily living that are limited due to their amputation. …”

Past Climate Change and Plant Evolution in Western North America: A Case Study in Rosaceae by Mats Töpel (89449)

“…Recent phylogenetic analyses have shown that the sister group of this clade is <em>Potentilla</em> section <em>Rivales</em>, a group with distinct moist habitat preferences. …”

Genetic variants in mitochondrial sirtuins associated with brain tumor risk: a case–control study by Maria Fazal Ul Haq (14659737)

“…Haplotype analysis and linkage disequilibrium (LD) showed a strong LD in brain tumor patients. Kaplan–Meier analysis showed that mutant allele frequency was found to be associated with a significant decrease in the survival of brain tumor patients.…”

eNOS-Dependent Antisenscence Effect of a Calcium Channel Blocker in Human Endothelial Cells by Toshio Hayashi (521209)

“…Exposure of HUVECs to high glucose (22 mM) for 3 days increased senescence-associated- β-galactosidase (SA-β-gal) activity, a senescence marker, and decreased telomerase activity, a replicative senescence marker. …”

<i>FOXO1</i> is a direct target of miR-582-5p. by Yanhua Liu (164798)

“…(C) Co-transfection of miR-582-5p mimics/mimics NC and <i>FOXO1</i> 3′UTR-luciferase reporter vector into HEK-293T cells demonstrated that significant decrease in luciferase activity was only found in reporter vector that contained a wild type sequence (FOXO1-3′UTR-wt), not in vector that contained a mutant sequence (FOXO1-3′UTR-mut) within the miR-582-5p binding site. …”

p53 acts as a gatekeeper by preventing progression of oncogenically activated cells to full malignancy. by George Hinkal (371132)

“…When p53 is deleted by tamoxifen injection at 3, 6, or 12 months or following IR treatment in CreERT2-p53^F/F mice, some oncogenic clones will progress to form a malignant cancer. For the p53^F/F mice, the median and maximal tumor latencies following p53 deletion decrease with age or with carcinogenic insult. …”

Supplementary Material for: Effects of exercise during chemo- or radiotherapy on immune markers – a systematic review by DeHoop A.M.S. (17085538)

“…The majority of markers was unaltered, but observed effects included a suppressive effect of exercise during radiotherapy on some pro-inflammatory markers, a preserving effect of exercise during chemotherapy on NK cell degranulation and cytotoxicity, a protective effect on the decrease in thrombocytes during chemotherapy, and a positive effect of exercise during chemotherapy on IgA. …”

Endothelial Dysfunction and Inflammation Precedes Elevations in Blood Pressure Induced by a High-Fat Diet by Jorge Camargo Oishi (5675510)

“…Results: Levels of pro-inflammatory cytokines began to increase after six weeks of a high-fat diet, while those of the anti-inflammatory cytokine adiponectin decreased. …”

Structural and functional analysis of cell-free produced PfAQP without a GFP fusion. by Annika Müller-Lucks (147176)

“…Changes in the light scattering intensity reflect liposome shrinkage due to water efflux (increase in light scattering) and liposome swelling due to glycerol plus secondary water influx (decrease in light scattering). Note the difference of the scale of the abscissae as a consequence of lower glycerol permeability by at least one order of magnitude. …”

Disease course of Chronic Relapsing Inflammatory Optic Neuropathy (CRION) in a single care center by Luis Enrique MOLINA-CARRIÓN (12687286)

“…Currently, all patients are on maintenance treatment with mycophenolate mofetil or rituximab with a decrease in relapsing rate. Conclusions: Diagnosis of CRION is challenging and should be kept in mind. …”

Mouse Transplant Models for Evaluating the Oncogenic Risk of a Self-Inactivating XSCID Lentiviral Vector by Sheng Zhou (66217)

“…<div><p></p><p>Hematopoietic stem cell gene therapy requires the use of integrating retroviral vectors in order to stably transmit a therapeutic gene to mature blood cells. Human clinical trials have shown that some vector integration events lead to disrupted regulation of proto-oncogenes resulting in disordered hematopoiesis including T-cell leukemia. …”

Supplementary Material for: Effects of exercise during chemo- or radiotherapy on immune markers – a systematic review by DeHoop A.M.S. (17085538)

“…The majority of markers was unaltered, but observed effects included a suppressive effect of exercise during radiotherapy on some pro-inflammatory markers, a preserving effect of exercise during chemotherapy on NK cell degranulation and cytotoxicity, a protective effect on the decrease in thrombocytes during chemotherapy, and a positive effect of exercise during chemotherapy on IgA. …”

Predicting the Impact of Vaccination on the Transmission Dynamics of Typhoid in South Asia: A Mathematical Modeling Study by Virginia E. Pitzer (143006)

“…Vaccination was predicted to confer substantial indirect protection leading to a decrease in the incidence of typhoid in the short term, but (intuitively) typhoid incidence was predicted to rebound 5–15 years following a one-time campaign.…”

Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model by Guiyun Mi (835541)

“…In addition, we performed a double labeling of BrdU and Ki-67 to calculate cell cycle exit index in the mice. …”

DataSheet2_A Zebrafish Model of Neurotoxicity by Binge-Like Methamphetamine Exposure.xlsx by Juliette Bedrossiantz (11736794)

“…After an initial testing at 20 and 40 mg/L for 48 h, the later METH concentration was selected for developing the model and the effects on the brain monoaminergic profile, locomotor, anxiety-like and social behaviors as well as on the expression of key genes of the catecholaminergic system were determined. A concentration- and time-dependent decrease in the brain levels of dopamine (DA), norepinephrine (NE) and serotonin (5-HT) was found in METH-exposed fish. …”

A few <i>Xenopus laevis</i> homeologous gene pairs display spatial subfunctionalization. by Jean-Louis Plouhinec (92231)

“…We found that most pairs with differential expression exhibit asymmetrical decrease of 1 copy (e.g., <i>egr4</i>, <i>sh3pxd2a</i>, <i>snail2</i>, <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2004045#pbio.2004045.g007" target="_blank">Fig 7</a>, <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2004045#pbio.2004045.s011" target="_blank">S11 Fig</a>). …”

Changing EDSS Progression in Placebo Cohorts in Relapsing MS: A Systematic Review and Meta-Regression by Christian Röver (790648)

“…<div><p>Background</p><p>Recent systematic reviews of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS) revealed a decrease in placebo annualized relapse rates (ARR) over the past two decades. …”

Combination of MG132 and RA induces p53-independent apoptosis and RelA inhibition. by Barbara Hämmerle (36261)

“…Both MG132 as well as RA cause significant decrease of nuclear expression of RelA (p65) protein. …”

A META-ANALYSIS OF THE EFFECTS OF GREEN TEA COMBINED WITH PHYSICAL ACTIVITY ON BLOOD LIPIDS IN HUMANS by Tengfei Zhang (794004)

“…In the subgroup and sensitivity analyses of the five studies, the TC levels of the subjects who received a lower dose of epigallocatechin gallate (EGCG) together with performing physical activity were significantly decreased. …”

Disruption of the exocyst causes a discordant effect on HuH7 uptake of LDL and transferrin. by Brian T. Emmer (8356980)

“…Reduction in gRNA frequency reflects a decrease in LDL or transferrin uptake or LDLR staining. …”