Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the <em>HNF4A</em> Gene by Ewan R Pearson (25176)

“…This study establishes a key role for <em>HNF4A</em> in determining foetal birthweight, and uncovers an unanticipated feature of the natural history of <em>HNF4A</em>-deficient diabetes, with hyperinsulinaemia at birth evolving to decreased insulin secretion and diabetes later in life.…”

Image2_Exploring Ecoacoustic Trajectories in a Giant Sequoia Forest After Wildfire.JPEG by Erik Meyer (1839514)

“…<p>Forest management strategies that create spatially diverse fire-caused disturbance outcomes, consistent with historic fire regimes, are a desired condition for fire adapted western United States forests. …”

CcpA-Independent Glucose Regulation of Lactate Dehydrogenase 1 in <em>Staphylococcus aureus</em> by Adrianne K. Crooke (105181)

“…Full <em>ldh</em>1-induction requires the presence of glucose, and mutants lacking the Carbon-Catabolite Protein (CcpA) exhibit decreased <em>ldh</em>1 transcription and diminished Ldh1 activity. …”

Primary human B cells form a survival niche for intracellular <i>Salmonella</i>. by Yuri Souwer (116128)

“…<p>(A) Widefield fluorescence microscopy of living Ramos and primary human B cells with phagocytosed anti-IgM coated GFP-<i>Salmonella</i>. …”

Spatial distribution of 12 class B notifiable infectious diseases in China: A retrospective study by Bin Zhu (182882)

“…<div><p>Background</p><p>China is the largest developing country with a relatively developed public health system. To further prevent and eliminate the spread of infectious diseases, China has listed 39 notifiable infectious diseases characterized by wide prevalence or great harm, and classified them into classes A, B, and C, with severity decreasing across classes. …”

Male breast cancer: a nation-wide population-based comparison with female breast cancer by Marianne D. Lautrup (4716543)

“…</p> <p><b>Results:</b> We found a marked difference in OS for the two genders. …”

Genetic Analysis of the Cardiac Methylome at Single Nucleotide Resolution in a Model of Human Cardiovascular Disease by Michelle D. Johnson (669638)

“…We observed preferential nucleotide usage associated with increased and decreased methylation that is remarkably conserved across species, suggesting a common mechanism for germline control of inter-individual variation in CpG methylation. …”

Image_1_Mutations in FIGLA Associated With Premature Ovarian Insufficiency in a Chinese Population.JPEG by Libin Mei (3492464)

“…Two patients carried the mutation c.11C>A (p.A4E), and the other two patients, respectively, carried the mutations c.625G>A (p.V209I) and c.84C>A (p.D28E). …”

Image_1_Risk Factors of Silicosis Progression: A Retrospective Cohort Study in China.TIF by Hua Quan (12339904)

“…Background<p>Silicosis poses a threat to workers’ health due to the irreversible lung lesions.…”

Determinants of the Changes in Glycemic Control with Exercise Training in Type 2 Diabetes: A Randomized Trial by Neil M. Johannsen (312617)

“…</p><p>Conclusions</p><p>Decreases in HbA_1C after 9 months of exercise were associated with shorter duration of diabetes, lowering of serum FFA concentrations, increasing serum adiponectin concentrations and increasing skeletal muscle PGC-1α protein expression.…”

Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity by Xiaoya Ma (536145)

“…The eAT histology revealed iron retention, macrophage clustering, tissue fibrosis, cell death as well as accumulation of HIF-2α in the high iron eAT. qPCR showed significantly decreased <i>Lep</i> (leptin) and <i>AdipoQ</i> (adiponectin), whereas <i>Tnfα</i> (tumor necrosis factor α), and <i>Slc40a1</i> (ferroportin) were up-regulated in HI (p<0.05). …”

An Equity-Focused Evaluation of a Medicaid-funded Statewide Diabetes Quality Improvement Project Collaborative by Joshua J. Joseph (19443725)

“…In year 2 compared to baseline, there were decreases in the proportion of patients with A1c >9% in NHW, NHB and Hispanic patients (NHW 19% to 12% [37% reduction]; NHB 23% to 18% [22% reduction]; and Hispanic 29% to 23% [20% reduction]).…”

Development of a Reactive Stroma Associated with Prostatic Intraepithelial Neoplasia in EAF2 Deficient Mice by Laura E. Pascal (486278)

“…Mice deficient in EAF2 had an increased recovery rate and a decreased overall response to the effects of androgen deprivation. …”

Just-in-Time Information Improved Decision-Making in Primary Care: A Randomized Controlled Trial by Jessie McGowan (269168)

“…A total of 1,889 questions were sent to the service by 88 participants. …”

Table 1_Association of the ROX index with mortality in sepsis patients: a retrospective study.docx by Jiali Wu (701228)

“…Restricted cubic spline analysis revealed a nonlinear “L”-shaped association, with the 28-day mortality risk decreasing until reaching a plateau at a ROX index of approximately 10.50. …”

Elimination of Schistosomiasis Transmission in Zanzibar: Baseline Findings before the Onset of a Randomized Intervention Trial by Stefanie Knopp (108848)

“…</p><p>Methodology</p><p>In early 2012, a baseline parasitological survey was conducted in ∼20,000 people from 90 communities in Unguja and Pemba. …”

Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever by Liang Cui (446525)

Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies by Luis A. García Rodríguez (594336)

“…</p><p>Conclusions</p><p>The risks of major bleeding with low-dose aspirin in real-world settings are of a similar magnitude to those reported in randomized trials. …”

Image_2_Mutations in FIGLA Associated With Premature Ovarian Insufficiency in a Chinese Population.JPEG by Libin Mei (3492464)

“…Two patients carried the mutation c.11C>A (p.A4E), and the other two patients, respectively, carried the mutations c.625G>A (p.V209I) and c.84C>A (p.D28E). …”

Evaluation of the cytotoxicity of the Bithionol-paclitaxel combination in a panel of human ovarian cancer cell lines by Vijayalakshmi N. Ayyagari (4449358)

“…In the present study, we focused on the anti-tumor potential of the BT-paclitaxel combination when added to a panel of ovarian cancer cell lines. This <i>in vitro</i> study aimed to 1) determine the optimum schedule for combination of BT and paclitaxel and 2) assess the nature and mechanism(s) underlying BT-paclitaxel interactions. …”