Morpholino-mediated knockdown of <i>lin-28a</i> and <i>lin-28b</i> affects early development. by Yasuo Ouchi (54268)

“…The frequencies of the phenotypes were similar between <i>lin-28a</i> and <i>lin-28b</i> morphants. The frequency of the dead, mild and severe phenotypes decreased with a rescue experiment in which 300 pg of <i>lin-28a</i> and <i>lin-28b</i> mRNAs were co-injected with the MO. …”

Table3_Causal relationship between plasma lipidome and four types of pancreatitis: a bidirectional Mendelian randomization study.xlsx by Runzhou Ma (19758996)

“…Background<p>Pancreatitis is a serious and complex inflammatory disease that imposes a severe effect on quality of life. …”

Image_2_Circular RNA hsa_circ_0007507 May Serve as a Biomarker for the Diagnosis and Prognosis of Gastric Cancer.tif by Weiwei Zhang (222964)

“…Exonuclease digestion assay, actinomycin D, agarose gel electrophoresis (AGE), and Sanger sequencing verified the potential of hsa_circ_0007507 as a biomarker. Besides, a real-time fluorescent quantitative polymerase chain reaction (RT-qPCR) was established to detect the level of expression of hsa_circ_0007507. …”

Image_3_Circular RNA hsa_circ_0007507 May Serve as a Biomarker for the Diagnosis and Prognosis of Gastric Cancer.tiff by Weiwei Zhang (222964)

“…Exonuclease digestion assay, actinomycin D, agarose gel electrophoresis (AGE), and Sanger sequencing verified the potential of hsa_circ_0007507 as a biomarker. Besides, a real-time fluorescent quantitative polymerase chain reaction (RT-qPCR) was established to detect the level of expression of hsa_circ_0007507. …”

Table_1_Association of high estimated glomerular filtration rate with risk of atrial fibrillation: a nationwide cohort study.xlsx by Min Kyoung Kang (3829759)

“…The eGFR <30 mL/min/1.73 m² group was associated with an increased risk of AF [hazard ratio (HR): 1.22, 95% confidence interval (CI) (1.01, 1.46), p = 0.039], while the eGFR >120 mL/min/1.73 m² group was associated with a decreased risk of AF [HR: 0.88, 95% CI (0.78, 0.98), p = 0.045]. …”

A model for zebrafish sex determination: oocyte survival regulated by Tp53-mediated apoptosis can alter gonad fate. by Adriana Rodríguez-Marí (53698)

“…<p>This model suggests germ cell apoptosis as a central feature that can integrate genetic and environmental factors to tip the fate of the gonad towards the female or the male pathway and thus determine zebrafish sex. …”

Table 1_The impact of comorbidities on surgical outcome and mortality in minimally invasive mitral valve surgery: a systematic review.docx by Vanessa I. T. Zwaans (22163257)

“…The average EuroSCORE II showed a median value of 1.75% (IQR: 1.20, 2.95) and NYHA class III was most frequent. …”

White-to-opaque switching frequencies of single TF heterozygotes in a <i>WOR1</i>(KR-to-G) strain background. by Collin Ganser (8924843)

“…<p><b>(A)</b> Switching assays were performed with WT <i>WOR1</i> or a KR-to-G variant of <i>WOR1</i>. …”

Data_Sheet_1_Anaerobic Conversion of Saline Phenol-Containing Wastewater Under Thermophilic Conditions in a Membrane Bioreactor.docx by Julian D. Muñoz Sierra (9443015)

“…Correspondingly, hydrogenotrophic methanogens of the class Methanomicrobia, together with Synergistia, Thermotogae, and Clostridia classes, dominated the microbial community and were enriched during the three phases of operation, while the aceticlastic Methanosaeta species remarkably decreased. Our findings clearly showed that highly saline phenolic wastewaters could be satisfactorily treated in a thermophilic AnMBR and that the specific phenol conversion capacity was limiting the treatment process. …”

Relationship of different levels of physical activity on the health status of long-term breast cancer survivors: a cross-sectional study by Francisco Álvarez-Salvago (21338477)

“…Patients should understand that physical activity is not merely a "lifestyle recommendation" but a biological necessity.…”

Image_3_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

5-HT2A and Foxo are required in R2/R4 neurons to mediate the effects of death perception on lifespan. by Christi M. Gendron (14200157)

“…(F) The amount of <i>Thor</i> mRNA, a Foxo target gene, was decreased in the heads of flies exposed to dead compared to unexposed flies (<i>n</i> = 16 each treatment). …”

DataSheet1_Anti-cancer activity of guggulsterone by modulating apoptotic markers: a systematic review and meta-analysis.docx by Meenakshi Gupta (3462941)

“…</p><p>Results: Based on this review, guggulsterone significantly affected pancreatic cancer (MiaPaCa-2, Panc-1, PC-Sw, CD18/HPAF, Capan1, PC-3), hepatocellular carcinoma (Hep3B, HepG2, PLC/PRF/5R), head and neck squamous cell carcinoma (SCC4, UM-22b, 1483), cholangiocarcinoma (HuCC-T1, RBE, Sk-ChA-1, Mz-ChA-1) and oesophageal adenocarcinoma (CP-18821, OE19), prostrate cancer (PC-3), colon cancer (HT-29), breast cancer (MCF7/DOX), gut derived adenocarcinoma (Bic-1), gastric cancer (SGC-7901), colorectal cancer (HCT116), bladder cancer (T24, TSGH8301), glioblastoma (A172, U87MG, T98G), histiocytic leukemia (U937), acute myeloid leukemia (HL60, U937) and non-small cell lung cancer (A549, H1975) by inducing apoptotic pathways, inhibiting cell proliferation, and regulating the expression of genes involved in apoptosis. …”

Image_6_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Image_8_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Table_1_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.xlsx by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Image_7_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Image_1_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Image_2_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

“…Nest, the Risk score system was constructed with moderate sensitivity and specificity. A high CRG Risk score, characterized by decreased microsatellite instability-high (MSI-H), tumor mutation burden (TMB) and cancer stem cell (CSC) index, and high stromal and immune score in TME, indicated poor survival. …”

Recruitment of α5-GABA_ARs to PV-synapses contributes to wake-dependent enhancement of iLTP. by Kunwei Wu (725668)

“…(K) Representative PV-IPSC traces at indicated time points in (J). (L) L655,708 decreased the potentiation of PV-IPSC amplitude after NMDA application in wake and sleep-deprived mice (SD) but not sleep mice (<i>n</i> = 7–8, 2-way ANOVA, F (4, 38) = 4.234, <i>p</i> = 0.0062 with Sidak’s multiple comparison test, Sleep a versus Sleep b, <i>p</i> = 0.028; Sleep a versus Sleep c, <i>p</i> = 0.04; Wake a versus Wake b, <i>p</i> = 0.0014; Wake b versus Wake c, <i>p</i> = 0.023; Wake a versus Wake c, <i>p</i> = 0.0008; SD a versus SD b, <i>p</i> < 0.0001; SD b versus SD c, <i>p</i> = 0.0091; SD a versus SD c, <i>p</i> = 0.0002; Sleep b versus Wake b, <i>p</i> = 0.028; Sleep b versus SD b, <i>p</i> = 0.04). …”