Synopsis of progressively abnormal synaptic signaling in old A53T-SNCA striata. by Alexander Kurz (10807)

“…Postsynaptically, the upregulation of DRD1A and DRD2 and the decreased transcript levels of several DA-inducible genes suggest a progressively diminishing striatal DA response. …”

A and B, plots of <i>N vs. t</i> and <i>W vs. t</i> resulting from the numerical solution, with <i>k</i> = 1, of the equations corresponding to the networks in Figures 1A and 1B, r... by Moisés Santillán (85107)

“…<p>C and D, plots of <i>N vs. t</i> and <i>k vs. t</i> as <i>k</i> decays, for the models corresponding to the networks in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001561#pone-0001561-g001" target="_blank">Figures 1A and 1B</a>. …”

Possible brain Aβ clearance mechanisms by Deng-Shun Wang (21099)

“…Increased production (like in familial AD) and/or decreased clearance (for most sporadic AD) will result in elevated brain Aβ levels and potentially trigger or accelerate the pathogenesis of AD. …”

The migratory behaviors of both Beas2B and A549 cells. by Shikun Wang (429367)

“…More Beas2B cells invaded after transfection with the pcDNA3-HA-RBP2 plasmid (<i>P</i> = 0.0011), whereas the number of invaded A549 cells significantly decreased when treated with RBP2 siRNA2 (<i>P</i> = 0.0005). …”

A model describing the functions of eEF1Bγ and eEF1A during tombusvirus replication. by Zsuzsanna Sasvari (193701)

“…<p>(A) Schematic representation of the secondary structure of the TBSV 3′ end and the RSE-gPR interaction. …”

TNFα and TGFβ1 induce EMT in A549 cells. by Atsushi Shiozaki (141857)

“…(D) The 72 h treatment with TNFα and TGFβ1 decreased expressions of E-Cadherin and Occludin, epithelial markers, and increased expressions of Vimentin, a mesenchymal marker, in A549 cells. …”

The mature form of miR-33a, miR-33a-5p downregulates the β-catenin gene. by Yi Fang (287944)

“…The β-catenin protein levels were normalized relative to β-actin in (A). (C) miR-33a-5p decreases β-catenin mRNA levels in Chang liver and HepG2 cells. …”

Increased total cell counts and pro-inflammatory cytokines in BAL fluid from SP-A -/- mice. by Anastasia K. Ketko (491544)

“…IL-1β was decreased in the lung of SP-A-/- mice 6 hours following PAK infection and no difference was observed in IL-1β between SP-A-/- and SP-A+/+ mice following <i>fliC</i> infection (B). …”

Recombinant IL-4 suppressed the stimulatory effect of PGI₂ analogs on IL-17A expression. by Weisong Zhou (165396)

“…<p>CD11c⁺ cell-containing CD4⁺CD62L⁺ cells isolated from spleens of OT II mice were activated with OVA_323–339 (1 µg/ml) and anti-CD28 (1 µg/ml) in the presence of IL-23 (10 ng/ml) and treated with iloprost, cicaprost, or respective vehicles for 4 days. (A and B) Iloprost and cicaprost decreased IL-4 production, but not IFN-γ production as determined by ELISA. …”

Effect of MDMA and HT on the a-wave and b-wave at 3 h and 24 h. by João Martins (5652628)

“…(A₂, B₂) Both MDMA and HT groups presented decreased time to peak values at 3 h time point when compared to Baseline ERG in both the a-wave and b-wave, while no significant differences were found at 24 h time point compared to Baseline ERG in all groups. *** p<0.001 MDMA group compared to Baseline ERG; ++ p<0.01, +++ p<0.001 HT group compared to Baseline ERG. …”

Hemoglobin A1c Levels and Risk of Severe Hypoglycemia in Children and Young Adults with Type 1 Diabetes from Germany and Austria: A Trend Analysis in a Cohort of 37,539 Patients be... by Beate Karges (640991)

“…From 1995 to 2012, the relative risk (RR) for severe hypoglycemia and coma per 1% HbA1c decrease declined from 1.28 (95% CI 1.19–1.37) to 1.05 (1.00–1.09) and from 1.39 (1.23–1.56) to 1.01 (0.93–1.10), respectively, corresponding to a risk reduction of 1.2% (95% CI 0.6–1.7, <i>p</i><0.001) and 1.9% (0.8–2.9, <i>p</i><0.001) each year, respectively. …”

Human A53T α-Synuclein Causes Reversible Deficits in Mitochondrial Function and Dynamics in Primary Mouse Cortical Neurons by Li Li (14993)

“…Furthermore, we found that rapamycin, an autophagy inducer, rescued the decreased mitochondrial mobility. Taken together, these data demonstrate that A53T α-syn impairs mitochondrial function and dynamics and the deficit of mitochondrial transport is reversible, providing further understanding of the disease pathogenesis and a potential therapeutic strategy for PD.…”

Knockdown of transcription factors, SP1 and EGR1, attenuates miR-27a expression. by Bum-Yong Kang (350760)

“…HPAEC mRNA or proteins were then isolated. qRT-PCR was performed demonstrating decreases in SP1 (<b>A</b>) or EGR1 (<b>C</b>) mRNA levels following treatment with siRNA. …”

Efficient assembly of CENP-A at centromeres requires SMC2. by Alexander Samoshkin (260480)

“…<p>A) CENP-A levels are not significantly decreased in condensin-depleted cells. …”

Vitamin A supplementation reduces the Th17-Treg – Related cytokines in obese and non-obese women by Mahdieh Abbasalizad Farhangi (7513307)

“…The mean concentrations of IL-17 and TGF-β were significantly decreased after vitamin A supplementation in non-obese and obese women respectively. …”

<i>In vivo</i> dynamic near-infrared fluorescent imaging of A-431 tumor models. by Lingbo Zhang (132359)

“…<p>A: The representative fluorescence images of the tumor regions in mice were acquired at 4 h post injection of EGF-Cy5.5. …”

Estimation of A3G and Vif production rates. by Iraj Hosseini (184245)

“…<p>(A) shows the optimum <i>P_A3G</i> for the ΔVif case (<i>P_Vif</i> = 0), whereas (B) shows the fitness error heat-map for a wide range of values of (<i>P_Vif</i>, <i>P_A3G</i>) for the WT case. …”

Modified αSOs co-localise with excitatory synapses. by Femke van Diggelen (6499112)

Let-7a Is a Direct EWS-FLI-1 Target Implicated in Ewing's Sarcoma Development by Claudio De Vito (210326)

“…Consistent with these observations, systemic delivery of synthetic let-7a into ESFT-bearing mice restored its expression in tumor cells, decreased <em>HMGA2</em> expression levels and resulted in ESFT growth inhibition in vivo. …”

Regulation of USP2a and MDM2 in response to <i>as-</i>APF. (A by Jayoung Kim (153487)

“…Western blot with anti-USP2a antibody showed that the level of USP2a level was stably decreased in response to <i>as</i>-APF treatment, but this was only transiently reduced by control mock APF peptide. …”