The effectiveness and safety of various treatments for hemophilia in China: a literature review and evidence mapping by Yu Yang (83671)

“…This study revealed a decrease in both annualized bleeding rate (ABR) and annualized joint bleeding rate (AJBR) following prophylaxis treatment and immune tolerance induction (ITI) treatment. …”

Smallest Maximum Intramolecular Distance: A Novel Method to Mitigate Pregnane Xenobiotic Receptor Activation by Michael J. Bower (8582544)

“…We present a novel molecular descriptor, the smallest maximum intramolecular distance (SMID), which is correlated with PXR activation, and a method for using the SMID descriptor to guide discovery chemists in modifying lead compounds to decrease PXR activation.…”

A Sensitive Water-Soluble Reversible Optical Probe for Hg²⁺ Detection by Sayani Das (5116985)

“…The molecule acts as a reversible “ON–OFF” fluorescent sensor for Hg²⁺ with a 35 times decrease in the emission intensity in the presence of 1 equiv of Hg²⁺ ions. …”

A Sensitive Water-Soluble Reversible Optical Probe for Hg²⁺ Detection by Sayani Das (5116985)

“…The molecule acts as a reversible “ON–OFF” fluorescent sensor for Hg²⁺ with a 35 times decrease in the emission intensity in the presence of 1 equiv of Hg²⁺ ions. …”

<em>Alu</em> Sequences in Undifferentiated Human Embryonic Stem Cells Display High Levels of A-to-I RNA Editing by Sivan Osenberg (145941)

“…We identified high editing levels of <em>Alu</em> repetitive elements in hESCs and demonstrated a global decrease in editing levels of non-coding <em>Alu</em> sites when hESCs are differentiating, particularly into the neural lineage. …”

Down regulation of A-RAF by either AR149 or A-RAF siRNA interferes with activation of ARF6. by Elena Nekhoroshkova (267173)

“…ARF6•GTP was pulled-down by GST-GGA3. AR149 decreases EFA6-stimulated ARF6 activation. F. ARF6 activation by EGF or EFA6 requires A-RAF. …”

Data Sheet 1_Isoform-specific vs. pan-histone deacetylase inhibition as approaches for countering glioblastoma: an in vitro study.docx by Ameya Joshi (1290186)

“…Introduction<p>Glioblastoma (GBM) is a grade 4 brain tumor that originates in astrocytes. …”

Prospective evaluation of micropulse transscleral diode cyclophotocoagulation in refractory glaucoma: 1 year results by Alessandro Adad Jammal (7368773)

“…Visual acuity loss was defined as a loss of ≥2 lines of vision on the Snellen chart or a ≥2-level decrease in visual function in patients with nonmeasurable chart acuity. …”

Table 1_Trends and forecasts of vitamin A deficiency burden in China, 1990–2035.docx by Zhongming Ye (21865547)

“…Objective<p>The purpose of this study was to analyze changes in the disease burden caused by vitamin A deficiency (VAD) in China from 1990 to 2021, based on the Global Burden of Disease (GBD) Database, and to predict the disease burden trend in 2035 using the Bayesian age-period-cohort (BAPC) model.…”

VDR siRNA-mediated knockdown does not change the expression of LVSCC-A1D mRNA and protein. by Duygu Gezen-Ak (355264)

“…Vitamin D treatment in VDR-silenced neurons led to a decrease in LVSCC-A1D protein levels. Beta actin was used as a loading control. …”

Enrichment of HP1a on Drosophila Chromosome 4 Genes Creates an Alternate Chromatin Structure Critical for Regulation in this Heterochromatic Domain by Nicole C. Riddle (134424)

“…However, when the chromatin is altered by depleting HP1a or POF, the RNA pol II enrichment patterns of many chromosome 4 genes shift, showing a significant decrease over gene bodies but not at TSSs, accompanied by lower expression of those genes. …”

Human SHBG mRNA Translation Is Modulated by Alternative 5′-Non-Coding Exons 1A and 1B by Tomàs Pinós (238160)

“…LNCaP prostate cancer cells transfected with several SHBG constructs containing exons 2 to 8 but lacking the 5′UTR sequence did show SHBG translation, whereas inclusion of the 5′UTR sequences of either exon 1A or 1B caused a dramatic decrease in SHBG protein levels. …”

A model of Aβ-induced toxicity and neuroprotection by NSAIDs based on mitochondrial Ca²⁺. by Sara Sanz-Blasco (271498)

“…<p>Aβ_1–42 oligomers and the toxic fragment Aβ_25–35 induce a large entry of Ca²⁺ through the plasma membrane likely mediated by formation of amyloid channels and/or NMDA receptors. …”

Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment by Shufeng Zhou (398572)

“…Moreover, we demonstrate that exosomes derived from human embryonic stem cells display anti-proliferation and pro-apoptotic effects, and decrease tumor size in a xenograft model. These exosomes are also able to transfer their cargo into target cancer cells, inducing a dose-dependent increase in SOX2, OCT4 and Nanog proteins, leading to a dose-dependent decrease of cancer cell growth and tumorigenicity. …”

AWOE surface tension (surrogate for interfacial tension) as a function of dispersant/modified dispersant fractions (C: Corexit dispersant). by Gerald F. John (7387964)

A focus on the development of adverse events. by Fabrizio Schettini (12009517)

Supporting data for "Diabetic corneal nerve injury: its diagnostic value in diabetic peripheral neuropathy and underlying mechanisms associated with deleted in liver cancer 2 (DLC2... by Ting Zhou (9068942)

“…Hyperglycemia can activate RhoA and spinal Deleted in liver cancer 2 (DLC2)/RhoA pathway was involved in inflammatory and neuropathic pain; but few studies focused on cornea. …”

Data Sheet 1_Meigs syndrome was misdiagnosed as a malignant ovarian tumor: a case report.pdf by Hongmei Li (51944)

“…Upon admission to our institution in April 2024, imaging confirmed a large pelvic mass, and subsequent diagnostic procedures indicated a likely fibroma. …”

Erythritol, a Non-Nutritive Sugar Alcohol Sweetener and the Main Component of Truvia®, Is a Palatable Ingested Insecticide by Kaitlin M. Baudier (572329)

“…Ingested erythritol decreased fruit fly longevity in a dose-dependent manner, and erythritol was ingested by flies that had free access to control (sucrose) foods in choice and CAFE studies. …”

Themes and sub-themes. by Maria Wemrell (6065699)

“…<div><p>Background</p><p>Lay online communication about health-related issues has in recent years largely been associated with the spread of misinformation and decreased trust in healthcare. …”