Interplay of Efflux Transporters with Glucuronidation and Its Impact on Subcellular Aglycone and Glucuronide Disposition: A Case Study with Kaempferol by Yuhuan Li (337260)

“…The inhibition and knockout of transporters, such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-associated proteins (MRPs), exhibited a marked increase in subcellular kaempferol and decrease in its subcellular glucuronides. …”

Interplay of Efflux Transporters with Glucuronidation and Its Impact on Subcellular Aglycone and Glucuronide Disposition: A Case Study with Kaempferol by Yuhuan Li (337260)

“…The inhibition and knockout of transporters, such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-associated proteins (MRPs), exhibited a marked increase in subcellular kaempferol and decrease in its subcellular glucuronides. …”

Presentation_1_Hypothesis and Theory: A Pathophysiological Concept of Stroke-Induced Acute Phase Response and Increased Intestinal Permeability Leading to Secondary Brain Damage.pd... by Fabienne Ferrara (8737980)

“…We found an increase of both APPs as well as a decrease of all anti-E. coli antibodies within 48 h following IS. …”

Lifespan of a single <i>T. utriculata</i> rosette. by Alexandra M. Campbell (3284094)

BPAG1a and b Associate with EB1 and EB3 and Modulate Vesicular Transport, Golgi Apparatus Structure, and Cell Migration in C2.7 Myoblasts by Kseniia Poliakova (632665)

“…Finally, knockdown of BPAG1a/b caused a specific decrease in the directness of cell migration, but did not impair initial cell adhesion. …”

(a) The basic reproduction number <i>R</i>₀ and (b) disease prevalence as a function of increasing movement rate (<i>k</i>) in a spatial network composed of 10 regions w... by Miguel A. Acevedo (381283)

(a) M-K test of annual average water level in Caspian Sea (unformatted fit (UF) and underidentification bias (UB) is positive and reverse order in the time series respectively; ɑ i... by Zihao Duan (17403792)

Image_1_Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells.tiff by Dave Francisco (1328862)

“…Given this activity, we developed 10 and 20 amino acid peptides of SP-A2 spanning position 223Q. We show that the SP-A 223Q peptides reduce eosinophilic inflammation, mucin production and airways hyperresponsiveness in a house dust mite model of asthma, protect from lung function decline during an IL-13 challenge model in mice, and decrease IL-13-induced MUC5AC gene expression in primary airway epithelial cells from asthmatic participants. …”

Image_2_Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells.tiff by Dave Francisco (1328862)

“…Given this activity, we developed 10 and 20 amino acid peptides of SP-A2 spanning position 223Q. We show that the SP-A 223Q peptides reduce eosinophilic inflammation, mucin production and airways hyperresponsiveness in a house dust mite model of asthma, protect from lung function decline during an IL-13 challenge model in mice, and decrease IL-13-induced MUC5AC gene expression in primary airway epithelial cells from asthmatic participants. …”

GLI1, DNMT1 and DNMT3a were inhibited in PANC-1 cell line after which treated by Cyclopamine. by ShanShan He (184687)

“…The inset shows a substantial decrease in GLI1, DNMT1 and DNMT3a expression. …”

Univariable and multivariable analysis of patients who returned to the same surgeon or a different for a subsequent hand surgery after a carpal tunnel release. by Scott J. Halperin (17835402)

3D snapshots of the tumor system with single-agent Lidamycin treatment at (a) time step 65, (b) time step 70 and (c) time step 85. by Minna Qiao (836556)

3D snapshots of the tumor system with single-agent GC treatment at (a) time step 60, (b) time step 65 and (c) time step 120. by Minna Qiao (836556)

Results from a two-way repeated measures ANOVA procedure comparing the effects of dietary taurine levels and light intensity (log I) on flicker fusion frequencies. by Richard W. Brill (2337940)

Map of studied gentoo penguin colony locations along a latitudinal gradient ranging from 1) Maiviken, South Georgia to 2) Georges Point, 3) Port Lockroy, and 4) Petermann Island on... by Caitlin Black (2141434)

Expression analysis in strain B728a of three FecI-like ECF σ factor genes (<i>ecf5</i>, <i>ecf7</i>, and <i>ecf6</i>) and associated putative iron-responsive genes in low and high... by Poulami Basu Thakur (389600)

“…Negative values indicate a decrease in expression levels as computed by taking the negative inverse of a fold change value less than 1.…”

Table_1_Immunodeficiency Promotes Adaptive Alterations of Host Gut Microbiome: An Observational Metagenomic Study in Mice.docx by Shuyu Zheng (5570231)

“…To explore the dynamic role of the microbiota in response to immune deficiency, we comprehensively assessed the microbiome of 90 mouse fecal samples, across three time points including two immunodeficiency models, namely severe combined immunodeficient (SCID) mice and non-obese diabetic SCID (NOD/SCID) mice, with BALB/cA as a control strain. Metagenomic analysis revealed a decrease in alpha diversity and the existence of a clear structural separation in the microbiota of immunodeficient mice. …”

Proposed role of VMH CPT1A in the hypothalamic control of satiety. by Paula Mera (562941)

“…Moreover, an up-regulation of VGAT transporter and a decrease in VGLUT2 may indicate enhanced inhibitory signalling which has been described to promote food intake. …”

Image_1_Immunodeficiency Promotes Adaptive Alterations of Host Gut Microbiome: An Observational Metagenomic Study in Mice.pdf by Shuyu Zheng (5570231)

“…To explore the dynamic role of the microbiota in response to immune deficiency, we comprehensively assessed the microbiome of 90 mouse fecal samples, across three time points including two immunodeficiency models, namely severe combined immunodeficient (SCID) mice and non-obese diabetic SCID (NOD/SCID) mice, with BALB/cA as a control strain. Metagenomic analysis revealed a decrease in alpha diversity and the existence of a clear structural separation in the microbiota of immunodeficient mice. …”

Image_1_Immunodeficiency Promotes Adaptive Alterations of Host Gut Microbiome: An Observational Metagenomic Study in Mice.pdf by Shuyu Zheng (5570231)

“…To explore the dynamic role of the microbiota in response to immune deficiency, we comprehensively assessed the microbiome of 90 mouse fecal samples, across three time points including two immunodeficiency models, namely severe combined immunodeficient (SCID) mice and non-obese diabetic SCID (NOD/SCID) mice, with BALB/cA as a control strain. Metagenomic analysis revealed a decrease in alpha diversity and the existence of a clear structural separation in the microbiota of immunodeficient mice. …”