A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D by Laura L. Eggink (760403)

“…Using plant lectins as analogs of lectin-type cell-surface receptors, a tetravalent form of a peptide with the sequence NPSHPLSG, designated svH1C, bound with high avidity to lectins specific for glycans with terminal 5-acetylneuraminic acid (Neu5Ac)-galactose (Gal)/N-acetylgalactosamine (GalNAc) sequences. …”

Image_1_Simultaneous targeting of Tim3 and A2a receptors modulates MSLN-CAR T cell antitumor function in a human cervical tumor xenograft model.jpeg by Tahereh Soltantoyeh (15944541)

“…To overcome this challenge, researchers have investigated the potential of inhibiting specific immune checkpoint receptors, including A2aR (Adenosine A2 Receptor) and Tim3 (T cell immunoglobulin and mucin domain-containing protein 3), to enhance CAR T cell function. …”

Image_5_Simultaneous targeting of Tim3 and A2a receptors modulates MSLN-CAR T cell antitumor function in a human cervical tumor xenograft model.jpeg by Tahereh Soltantoyeh (15944541)

“…To overcome this challenge, researchers have investigated the potential of inhibiting specific immune checkpoint receptors, including A2aR (Adenosine A2 Receptor) and Tim3 (T cell immunoglobulin and mucin domain-containing protein 3), to enhance CAR T cell function. …”

Image_4_Simultaneous targeting of Tim3 and A2a receptors modulates MSLN-CAR T cell antitumor function in a human cervical tumor xenograft model.jpeg by Tahereh Soltantoyeh (15944541)

“…To overcome this challenge, researchers have investigated the potential of inhibiting specific immune checkpoint receptors, including A2aR (Adenosine A2 Receptor) and Tim3 (T cell immunoglobulin and mucin domain-containing protein 3), to enhance CAR T cell function. …”

Image_3_Simultaneous targeting of Tim3 and A2a receptors modulates MSLN-CAR T cell antitumor function in a human cervical tumor xenograft model.jpeg by Tahereh Soltantoyeh (15944541)

“…To overcome this challenge, researchers have investigated the potential of inhibiting specific immune checkpoint receptors, including A2aR (Adenosine A2 Receptor) and Tim3 (T cell immunoglobulin and mucin domain-containing protein 3), to enhance CAR T cell function. …”

Supplementary Material for: Prenatal Infection Decreases Calbindin, Decreases Purkinje Cell Volume and Density and Produces Long-Term Motor Deficits in Sprague-Dawley Rats by Wallace K. (4120819)

“…Pups in the <i>E. coli</i> group also had a decrease in the number of Purkinje cells, as well as a decrease in Purkinje cell density and volume. …”

X‑ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson’s Disease Mouse Model by Jun Mou (4113313)

“…In a MPTP-induced Parkinson’s disease (PD) mouse model, <b>BI-43</b> manifested efficacy in mitigating locomotor deficits through reversing dopaminergic neuronal loss, reducing microglia, and decreasing levels of the sQC/gQC substrates, α-synuclein, and CCL2. …”

Architecture of early-combined model (Model (A)). by Wanchalerm Pora (8360934)

A block of diagram of the process of our method. by Shuting Liao (9524506)

Raw data as basis for a meta-analysis. by Chan Guo (6116351)

A visual summary of the key study findings. by Joachim Worthington (8394213)

“…These changes would lead to an estimated increase of 255 colorectal cancer cases and 1,820 colorectal cancer deaths in Canada and 234 cases and 1,186 deaths in Australia over 2020–2030; a 1.9% and 2.4% increase in mortality, respectively, vs a scenario with no screening disruption or diagnostic/treatment delays. …”

A: Reduced image; B: Focal area. by Shuting Liao (9524506)

Cinnamaldehyde is a specific ligand for HL-IR. by Ceyan Kuang (8554557)

“…The ratio of bound/free 1-NPN gradually decreased as the concentration of 1-NPN increased, accompanied by a corresponding rise in fluorescence intensity. …”

Number of pulmonary endothelial cells decreased upon infection and started to proliferate during resolution to restore their number by 15 dpi accompanied by decreased endothelial a... by Emilie Pollenus (10147748)

Five-(black) and seven-year (grey) sliding window correlations of three nesting parameters. by Sara E. Harrod (14129292)

HRMECs treated with SUZ12 siRNA demonstrate increased miR-200b expression, decreased VEGF expression and decreased endothelial branching. by Michael Anthony Ruiz (726055)

“…<p><b>A,B:</b> Gene knockdown of EZH2 and SUZ12 was confirmed by qPCR. …”

Effect of laser therapy on the inflammatory response induced by endodontic medications implanted into the subcutaneous tissue of rats by Felipe de Souza MATOS (6125111)

“…<div><p>INTRODUCTION: Endodontic medications contain toxic components that cause varying degrees of inflammation.OBJECTIVE: This study evaluated the effect of laser therapy on the inflammatory response induced by intracanal medications implanted into the subcutaneous tissue of rats using a quantitative analysis of mast cells.MATERIAL AND METHOD: Polyethylene tubes containing the medications were implanted in the dorsum of 60 rats divided into six groups, including HS (P.A. calcium hydroxide paste), HL (P.A. calcium hydroxide paste and laser therapy), HPS (P.A. calcium hydroxide paste with camphorated paramonochlorophenol), HPL (P.A. calcium hydroxide paste with camphorated paramonochlorophenol and laser therapy), IS (iodoform with saline) and IL (iodoform with saline and laser therapy). …”

Effect of Metformin Treatment on Lipoprotein Subfractions in Non-Diabetic Patients with Acute Myocardial Infarction: A Glycometabolic Intervention as Adjunct to Primary Coronary In... by Ruben N. Eppinga (848156)

“…In addition, increased medium-sized VLDL particles at the same time point predicted a smaller infarct size (<i>P</i><0.001).</p><p>Conclusion</p><p>LDL cholesterol and large LDL particles were decreased during 4 months treatment with metformin started early after MI. …”

Evolution of the four pre-stimuli psychological parameters (A: Valence, B: Arousal, C: Tension, D: Energy). by Felix Alexandre Schoeller (20988295)

Quiescent amastigotes exhibit a significantly reduced size compared to DsRed^hi amastigotes. by Laura Dirkx (8950205)