Data_Sheet_1_Generation and Validation of miR-100 Hepatocyte-Specific Knock-Out Mice.PDF by Dong Yang (141041)

“…<p>Background: Inactivation of microRNA-100 (miR-100) is involved in hepatocellular carcinoma (HCC) and miR-100 behaves as a tumor suppressor. To understand miR-100 function in HCC genesis and development in vivo, we developed hepatocyte-specific miR-100 deficient mice.…”

Reduction in endocytosis mitigates the cellular and morphological phenotype in Myosin Vb deficient embryos. by Sonal (631310)

“…The embryos classified as “no phenotypes” exhibited the decreased fin expansion and occasionally a few rounded up cells in the finfold. …”

Figure S5_2 from Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma by Joseph J. Caumanns (15010014)

“…<p>Supplementary Figure 5 | Clustering (n=106) and survival analysis (n=70) on kinome mutations and CNA. (A) Disease-specific survival of patients (n=70) grouped on ARID1A status, (B) PIK3CA status and (C) ARID1A + PIK3CA status. …”

Table_1_Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arterie... by Alvaro Navarrete (9621161)

“…The results show that mechanical response is related with histological results, specifically in the proximal abdominal aorta (PAA) and distal carotid zones (DCA), where the cell nuclei content is related to a decrease of residual deformations. The opening angle and the elastic fibers of the aorta artery were statistically correlated (p < 0.05). …”

Image_1_Skin Interstitial Fluid and Plasma Multiplex Cytokine Analysis Reveals IFN-γ Signatures and Granzyme B as Useful Biomarker for Activity, Severity and Prognosis Assessment i... by Chau Yee Ng (3953372)

“…It is essential to establish a biomarker profile as a substitute marker for disease activity to predict disease activity, severity, and prognosis prediction. …”

Independent experiment confirming that viral IE2 depletion in late infection does not affect viral long promoter transcription. by Qiaolin Hu (8677473)

“…(<b>A</b>) Western blot analysis shows that the dTag degrader decreased IE2^F-86 amount by 88%, compared to CTRL and normalized to the host actin control. …”

Table_5_The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum.DOCX by Thabatta Leal Silveira Andrezo Rosa (5489132)

“…During thalidomide administration, the drug of choice for ENL treatment, a decrease in the mRNA and protein levels of some of these genes both in the skin and blood was observed. …”

Combined Experimental and Computational Study of Ce-Doped La₃Zr₂Li₇O₁₂ Garnet Solid-State Electrolyte by Bo Dong (218172)

“…This doping strategy results in a reduction in the tetragonal distortion as well as a lowering of the temperature of the tetragonal–cubic phase transition, attributed to the increase in cell size reducing Li–Li interaction strain. …”

Data_Sheet_1_Substrate pH Influences the Nutrient Absorption and Rhizosphere Microbiome of Huanglongbing-Affected Grapefruit Plants.docx by Rhuanito Soranz Ferrarezi (8111315)

“…The root and shoot ratio of dry weight was 25.8% lower in HLB+ than in healthy plants. Poor root growth and a decrease in fibrous roots were found, especially in pH 5 and 6 treatments in HLB+ plants (p < 0.0001). …”

Image_2_The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum.TIF by Thabatta Leal Silveira Andrezo Rosa (5489132)

“…During thalidomide administration, the drug of choice for ENL treatment, a decrease in the mRNA and protein levels of some of these genes both in the skin and blood was observed. …”

datasheet1_The Immunomodulatory Potential of Copper and Silver Based Self-Assembled Metal Organic Biohybrids Nanomaterials in Cancer Theranostics.pdf by Neela Prajapati (10038521)

“…Successive treatment of CuHARS to glioma cells also proved to be an effective approach considering the decrease in the total count of cells by 11.84 fold in case of three successive treatments compared to a single dose which only decreased the cell count by 2.45 fold showing the dose-dependent increasing toxicity toward glioma cells. …”

Supplementary file 1_Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice.docx by Teame Gereziher Mehari (11253141)

“…Introduction<p>Gossypol impairs reproduction in both sexes, inducing mitochondrial dysfunction, irregular cycles, and fewer ovarian follicles, leading to decreased fertility rates. The present investigation was undertaken to evaluate the toxicological effects of (+)-gossypol powder, a substance derived from cottonseed in mice.…”

Discovery of Dramatically Improved Ammonia Synthesis Catalysts through Hierarchical High-Throughput Catalyst Screening of the Fe(211) Surface by Jon Fuller (6919253)

“…At 673 K and 20 atm, we find a decrease, δ­(Δ<i>G</i>^∫) = −0.19 eV, in the overall reaction free-energy barrier for the Co-doped case. …”

Macrophage-tropic HIV-1 isolates, which are known to bind human CD4 more tightly, are promiscuous in their use of primate CD4 receptors. by Cody J. Warren (563898)

“…<p>(A, B) Cells stably expressing various primate CD4 receptors (x-axis), along with human CCR5, were infected with Q23ΔEnv-GFP pseudotyped with (A) early HIV-1 Envelopes (Envs) or (B) Envs from common macrophage-tropic HIV-1 isolates. …”

NADH oxidase activities of recombinant gFlHb. by Edar O. Pech-Santiago (13871266)

“…<p>(A) The reaction was performed in 50 mM potassium phosphate buffer by adding 160 μM NADH at time zero, after 0.37 μM gFlHb (blue arrow) was added to reach a stable baseline with negligible spurious reaction. …”

Impact of BCG vaccination on the repertoire of human gamma/delta T cell receptors (ms data) by Mei Xia (14585347)

“…While many of the clonotypes whose frequency changed after BCG were not shared among multiple individuals in the cohort, several shared (i.e., “public”) clonotypes were identified with a consistent increase or decrease in frequency across more than one individual; the degree of sharing of these clonotypes was significantly greater than the minimal sharing that would be expected among gTCR and dTCR repertoires. …”

PLK2i treatment of OHSCs does not affect generation of pS129 positive aggregates, but reduces the nuclear pS129 intensity. by Sara Elfarrash (8159490)

“…Scale bars = 20 μm. b) Quantification of the amount of aggregation (aggregate area normalized to tissue area), defined by MJF-14 staining (p-value = 0.09). c-d) Quantification of the mean fluorescence intensity of α-syn aggregates detected with MJF-14 (c, p-value = 0.712) and aggregate-specific pS129 that overlaps with MJF-14 (d, p-value = 0.214). e) Quantification of nuclear (non-aggregate related) pS129, illustrating a significant decrease in mean fluorescence intensity following PLK2i-treatment (p-value = 0.0087). f) Relative ratio of aggregate-specific pS129/nuclear pS129 in PFF-injected slices shows an increase of ratio of the signals of aggregates/background following PLK2i treatment, due to reduction of the non-aggregate-related nuclear pS129-signal (p-value = 0.009). …”

Genetic ablation of <i>C1ql1</i>-expressing OPCs prevents myelination in the forebrain without affecting axogenesis. by Shayan Moghimyfiroozabad (19066182)

“…Quantification of the thickness of the fiber bundles in the corpus callosum and the intensity of NF in the cortex shows a small decrease in the thickness of the lateral part of the corpus callosum, probably explained by reduced myelination. …”

Table_3_Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis.xlsx by Roel Bijkerk (4662769)

“…In order to identify pericyte long non-coding RNAs (lncRNAs) that could serve as a target to decrease myofibroblast formation and counteract the progression of kidney fibrosis we employed two models of experimental kidney injury, one focused on kidney fibrosis (unilateral ureteral obstruction; UUO), and one focused on acute kidney injury that yields kidney fibrosis in the longer term (unilateral ischemia-reperfusion injury; IRI). …”

Table_7_Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis.DOCX by Roel Bijkerk (4662769)

“…In order to identify pericyte long non-coding RNAs (lncRNAs) that could serve as a target to decrease myofibroblast formation and counteract the progression of kidney fibrosis we employed two models of experimental kidney injury, one focused on kidney fibrosis (unilateral ureteral obstruction; UUO), and one focused on acute kidney injury that yields kidney fibrosis in the longer term (unilateral ischemia-reperfusion injury; IRI). …”