GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production by Corin Miller (4042664)

“…The decrease in EGP was not likely due to a direct effect on the liver, as isolated perfused liver studies showed no effect of MK-2305 <i>ex vivo</i> and GPR40 is not expressed in the liver. …”

<i>In vitro</i> and <i>in vivo</i> Bioactivity of Stomoxyn. by Erick O. Awuoche (4603582)

“…</b> Gene-silencing validation: The relative expression of <i>stomoxyn</i> was measured from dsGFP and dsStomoxyn<i>-</i>treated <i>Gff</i> flies, showing a significant decrease in expression (<i>p</i><0.0001) in the case of dsStomoxyn<i>-</i>treated group. …”

Raw experimental data Fig 3. by Feline F. W. Benavides (13694053)

“…Additionally, we detected increased microglial activation in the olfactory bulb and hippocampus, and a decrease in the astrocytic activation status in the white matter and hippocampus of SARS-CoV-2 inoculated ferrets. …”

Data Sheet 1_Clinical isolates of Providencia rettgeri and Providencia Stuartii evades neutrophil-mediated killing by subverting neutrophil-extracellular traps.pdf by Joselyn E. Castro (22355326)

“…This decrease was abolished by fixed bacteria, and was dependent on the release of a DNase activity. …”

Table2_Location and Species Matters: Variable Influence of the Environment on the Gene Flow of Imperiled, Native and Invasive Cottontails.docx by Thomas J. McGreevy (11497954)

“…New England cottontail (Sylvilagus transitionalis) is the only native cottontail in the Northeast US, an early successional habitat specialist, and a species of conservation concern. Eastern cottontail (S. floridanus) is an invasive species in the Northeast US and a habitat generalist. …”

Table_8_Towards Sensor-Based Phenotyping of Physical Barriers of Grapes to Improve Resilience to Botrytis Bunch Rot.xlsx by Katja Herzog (6185465)

“…These QTLs providing a starting point for the development of molecular markers. …”

Data_Sheet_1_Impact of Climate Change on Hydrochemical Processes at Two High-Elevation Forested Watersheds in the Southern Appalachians, United States.pdf by Hailong Huang (1449589)

“…We find that gross primary productivity (GPP), net primary productivity (NPP), transpiration, nitrogen mineralization, and streamflow are projected to increase, while soil base saturation, and base cation concentration and ANC of streamwater are projected to decrease at the annual scale but with strong seasonal variability under a changing climate, showing the general trend of acidification of soil and streamwater despite an increase in primary productivity. …”

DataSheet_1_Human monocyte-derived suppressive cells (HuMoSC) for cell therapy in giant cell arteritis.docx by Maxime Samson (4439077)

“…</p>Results<p>Transcripts of genes implicated in vascular inflammation (CCL2, CCR2, CXCR3, HLADR), vascular remodeling (PDGF, PDGFR), angiogenesis (VEGF) and extracellular matrix composition (COL1A1, COL3A1 and FN1) were decreased in arteries treated with HuMoSCs or their supernatant. …”

<em>Lactobacillus rhamnosus</em> (<em>LGG</em>) Regulates IL-10 Signaling in the Developing Murine Colon through Upregulation of the IL-10R2 Receptor Subunit by Julie Mirpuri (109883)

“…Furthermore, <em>LGG</em>-dependent increases in IL-10R2 were associated with reductions in TNF-α, MIP-2 and disease severity in a murine model of intestinal injury in the immature colon.…”

Image 1_Global, regional and national burdens of otitis media in children and adolescents from 1990 to 2021 and its predictions to 2040.tiff by Ru Chen (186859)

“…At the national level, countries with a high burden of OM are primarily concentrated in Sub-Saharan Africa and South Asia. …”

Table_3_Metabolomics analysis of splenectomy of Nile tilapia (Oreochromis niloticus) reveals the spleen involved in regulating liver lipids and amino acids metabolism.docx by Yixi Tao (11036286)

“…After splenectomy, biochemical parameters of the liver and serum showed abnormalities, including significant increases in total cholesterol (T-CHO) and serum total bile acid (TBA) levels, alongside a significant decrease in liver TBA levels, suggesting impaired metabolic function and cholesterol deposition in the liver. …”

Data_Sheet_2_The burden of liver cirrhosis in mortality: Results from the global burden of disease study.docx by Fei Ye (339913)

“…The ASR of mortality caused by hepatitis C virus (HCV), alcohol consumption, and non-alcoholic steatohepatitis (NASH) increased with an EAPC of 0.17 (95% CI, 0.14–0.20), 0.20 (95% CI, 0.16–0.24), 1.00 (95% CI, 0.97–1.04), respectively. A decreasing trend of ASR was found among the causes of hepatitis B virus (BV) and other causes. …”

WSSV infection induces <i>Chi2</i> expression through E75. by Xin-Xin Wang (135520)

“…<p>(A) Sequential transcription factors essential for cuticle biosynthesis. …”

Image_3_Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via... by Junping Bao (10931142)

“…On the contrary, further activating p-eIF2α aggravated the NP cell degeneration, with amplification of ATF4/Ihh and a higher level of ROS and apoptosis. Additionally, applying cyclopamine (CPE) to suppress Ihh was efficient to prevent NP cell apoptosis but did not decrease the ROS level. …”

Image_4_T cell receptor β repertoires in patients with COVID-19 reveal disease severity signatures.pdf by Jing Xu (15337)

“…</p>Results<p>We observed a decrease in the diversity of TCR clonotypes in COVID-19 patients compared to healthy controls. …”

Image1_DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage.png by Wenchao Tang (14710556)

“…</p>Results<p>Following CTD exposure, the mouse liver showed significant pathological damage and an increase in autophagic lysosomes, while the vitality of L-O2 cells showed a significant decrease. CTD led to a significant increase in the mRNA and protein levels of DDIT4 in both liver tissue and L-O2 cells, as well as a significant increase in LC3-II, Beclin1, and Bax, whereas p-mTOR and Bcl-2 were significantly decreased. …”

table2_Significant Regional Differences in Lung Cancer Incidence in Hungary: Epidemiological Study Between 2011 and 2016.docx by Gabriella Gálffy (177759)

“…</p><p>Results: The highest incidence rate in males was recorded in Northern Hungary (146.8/100,000 person-years [PY]), while the lowest rate was found in Western Transdanubia (94.7/100,000 PY in 2011). All rates showed a declining trend between 2011 and 2016, with the largest decrease in the Northern Great Plain (−20.0%; p = 0.008). …”

Table_4_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx by Yujia Zhang (757462)

“…The cell morphology altered dramatically 72 h after transfection, becoming rounder, with a decrease in cell number. BCP exhibited the potential to dramatically increase PC-12 cell viability while protecting cell morphology. …”

Comparison experiment of accuracy improvement. by Zhongjian Xie (4633099)

“…Firstly, improve the multi-scale feature layer and reduce the complexity of the model. Secondly, a lightweight convolutional module is introduced to replace the standard convolutions in the Efficient Long-range Aggregation Network (ELAN-A) module, and the channel pruning techniques are applied to further decrease the model’s complexity. …”

Data_Sheet_2_Population response of intestinal microbiota to acute Vibrio alginolyticus infection in half-smooth tongue sole (Cynoglossus semilaevis).zip by Yaotong Hao (15467570)

“…The metagenomic results suggest that a high-dose V. alginolyticus infection can significantly alter the intestinal microbiota, decrease the microbial α-diversity, and increase the bacteria from Vibrio and Shewanella, including various potential pathogens at 24 h. …”