Th1 Response and Systemic Treg Deficiency in Inclusion Body Myositis by Yves Allenbach (483114)

“…This was associated with an increased frequency of CD8⁺CD28⁻ T cells (45.6±18.5% vs. 13.5±9.9%; p<0.0001), which were more prone to produce IFN-γ (45.6±18.5% vs. 13.5±9.9%; p<0.0001). sIBM patients also had a decreased frequency of circulating regulatory T cells (CD4⁺CD25⁺CD127^lowFOXP3⁺, 6.9±1.7%; vs. 5.2±1.1%, p = 0.01), which displayed normal suppressor function and were also present in affected muscle.…”

Image 3_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…<p>Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. …”

Image_1_The Influence of Training Load on Hematological Athlete Biological Passport Variables in Elite Cyclists.TIFF by Tiffany Astolfi (10322177)

“…Hbmass was 1030 ± 87 g (range: 842–1116 g) with no significant variations over time (P = 0.118), whereas PV was 4309 ± 350 mL (range: 3,688–4,751 mL) with a time-effect observed over the study time (P = 0.014). …”

Data Sheet 1_Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile.pdf by Wei Chen (23863)

“…</p>Methods<p>The chemical composition of QRHSD was analyzed using quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). A UC mice model was induced by 3% DSS for 7 days. …”

Table_2_Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D-Galactose-Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota-Gut-... by Baiyan Liu (12869393)

“…Liuwei Dihuang decoction (LW), a commonly applied Chinese medicine formula, is widely used for the treatment of aging-related diseases in China. …”

Data_Sheet_1_Docosahexaenoic acid supplementation in gestational diabetes mellitus and neonatal metabolic health biomarkers.docx by Ya-Jie Xu (12755051)

“…</p>Methods<p>In a randomized controlled trial, singleton pregnant women with de novo diagnosis of GDM at 24–28  weeks of gestation were randomized to dietary supplementation of 500 mg DHA per day (intervention, n = 30) until delivery or standard care (control, n = 38). …”

DataSheet1_Etanercept embedded silk fibroin/pullulan hydrogel enhance cartilage repair in bone marrow stimulation.pdf by Xiongbo Song (11213176)

“…In cellular experiments, Ept treatment significantly promoted both gene and protein expression of type II collagen in hOACs, while decreased the protein levels of metalloproteinase (MMP)-13 and a disintegrin and metalloprotease with thrombospondin motifs 5 (ADAMTS5); alcian blue staining, type II collagen and aggrecan stainings showed that addition of Ept significantly reversed the chondrogenesis inhibition effect of tumor necrosis factor alpha (TNF-α) on hBMSCs.…”

Image_4_Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI.jpg by Neftali Ramirez (13251924)

“…In steady state, naïve B cells had increased cell death pathways and reduced cell metabolism pathways, while after stimulation, enhanced immune responses and decreased cell survival were detected. Using a multi-omics approach, our findings provide valuable insights into the impaired biology of naïve B cells from TACI mutation carriers.…”

Table1_Shifting Trade-offs: Finding the Sustainable Nexus of Hydropower and Environmental Flows in the San Joaquin River Watershed, California.XLSX by Ann D. Willis (11307490)

“…The functional flow strategy allocated water in a holistic approach that enhanced ecological functions in all years, but particularly in moderate and wet years. …”

Image_2_Exopolysaccharide-producing bacteria enhanced Pb immobilization and influenced the microbiome composition in rhizosphere soil of pakchoi (Brassica chinensis L.).pdf by Ruiwen Cao (5507192)

“…The potential of Pseudoalteromonas agarivorans Hao 2018, a high EPS-producing marine bacterium, to produce EPS in soil filtrate, immobilize Pb, and inhibit its uptake by pakchoi (Brassica chinensis L.) was studied in this work. …”

Supplementary Material for: Prostaglandin E₂ Regulates Activation of Mouse Peritoneal Macrophages by <b><i>Staphylococcus aureus</i></b> through Toll-Like Receptor 2, To... by Wu J. (3278256)

Data_Sheet_1_Effects of Coix Seed Extract, Bifidobacterium BPL1, and Their Combination on the Glycolipid Metabolism in Obese Mice.PDF by Wei Zhang (405)

“…Male C57BL/6J mice were fed a high-fat diet for 8 weeks to establish an obesity model. …”

Identification of candidate genes associated with photosynthesis in eggplant under elevated CO₂ by Xiaoyong Xu (276757)

“…A total of 169 differentially expressed genes (DEGs) were screened, of which 99 were up-regulated and 70 were down-regulated. …”

Data_Sheet_1_Mycoplasma gallisepticum Infection Impaired the Structural Integrity and Immune Function of Bursa of Fabricius in Chicken: Implication of Oxidative Stress and Apoptosi... by Wei Zhang (405)

“…<p>Mycoplasma gallisepticum (MG) induces a dysregulated immune response in the lungs and air ways of poultry. …”

Table1_Hydrogeochemistry of Hot Springs and the 2018 Mojiang M 5.9 Earthquake-Related Chemical Changes in the Simao Basin, China.docx by Qilin Li (535447)

“…Saline springs flowed through red beds and dissolved large amounts of halite, which is a rich source of Cl⁻and Na⁺ ions. …”

CSB recruits PCAF to rDNA promoter. by Meili Shen (410549)

“…<p>A. Inducible knockdown of CSB impairs Pol I and PCAF occupancy at rDNA promoter. …”

Distinct TCR repertoire in PIMS-TS/MIS-C patients: evidence for thymus involvement by Diana Yanez Marcayata (6785048)

“…<p dir="ltr">During the COVID-19 pandemic a rare new paediatric inflammatory condition (paediatric inflammatory multisystem temporally associated with COVID-19 (PIMS-TS)/MIS-C) was identified which correlated with previous or recent SARS-CoV-2 infection. …”

Table_2_Value of Literature Review to Inform Development and Use of Biologics in Juvenile Idiopathic Arthritis.docx by Klervi Golhen (12898574)

“…An enhanced effect for ACR Pedi 70 was observed with infliximab combined with methotrexate in PJIA vs. methotrexate monotherapy. A slightly higher risk of gastrointestinal AEs and infections was observed with treatment arms compared to placebo or methotrexate monotherapy.…”

GLP-1 effects on insulin secretion, proliferation and apoptosis are impaired in insulin receptor knockdown cells. by Nunzia Caporarello (221943)

“…<p>Panel A. Insulin secretion in INS-1E cells, transfected with insulin receptor siRNA. …”

Healthcare use, sickness absence, and disability pension among colorectal cancer survivors and population references in Sweden by Luisa Christine Beermann (11422044)

“…</p> <p>In this longitudinal register-based cohort study, 6679 patients with a first primary CRC in 2008–2011 (when aged 18–62) and 26,716 CRC-free matched references were followed from 2 years before up to 5 years after diagnosis date. …”