Proteomic Profiling in <i>Drosophila</i> Reveals Potential Dube3a Regulation of the Actin Cytoskeleton and Neuronal Homeostasis by Laura Jensen (405470)

“…<div><p>The molecular defects associated with Angelman syndrome (AS) and 15q duplication autism are directly correlated to expression levels of the E3 ubiquitin ligase protein UBE3A. Here we used <i>Drosophila melanogaster</i> to screen for the targets of this ubiquitin ligase under conditions of both decreased (as in AS) or increased (as in dup(15)) levels of the fly Dube3a or human UBE3A proteins. …”

Table_2_FOXO3a Alleviates the Inflammation and Oxidative Stress via Regulating TGF-β and HO-1 in Ankylosing Spondylitis.docx by Shanshan Xu (276428)

“…Total antioxidant capacity (T-AOC) were markedly decreased and positively associated with FOXO3a in AS. …”

Evolved <i>efgA</i> alleles have a variety of predicted folding and binding stabilities. by Jannell V. Bazurto (7847171)

“…<p>We used our MD+FoldX approach [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001208#pbio.3001208.ref079" target="_blank">79</a>] to predict the effect of all possible 19 mutations at each amino acid site on monomers or tetramer formation. …”

Table_1_PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.DOCX by Guangjin Chen (1989892)

“…Notably, the downregulation of PLAU decreased the expression of TNFRSF12A. Moreover, knockdown TNFRSF12A also inhibits cell proliferation and migration. …”

Table_6_FOXO3a Alleviates the Inflammation and Oxidative Stress via Regulating TGF-β and HO-1 in Ankylosing Spondylitis.docx by Shanshan Xu (276428)

“…Total antioxidant capacity (T-AOC) were markedly decreased and positively associated with FOXO3a in AS. …”

image_2.tif by Maopeng Tian (4890934)

“…Formulation of DNA and two agonists into the DDA liposome decreased zeta potential but increased the stability of storage, which resulted in a slower and longer-lasting release of DNA from the DNA–DMT complex than the DNA–DDA liposome. …”

DataSheet_1_METTL3-Mediated N6-Methyladenosine Modification of Trim59 mRNA Protects Against Sepsis-Induced Acute Respiratory Distress Syndrome.docx by Yi Chen (38576)

“…Here, we show that the levels of m⁶A RNA were significantly decreased in septic lungs and that METTL3 was the main regulator involved in the absence of m⁶A RNA modification. …”

Table_3_Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.xlsx by Sze Wing Wong (1617550)

“…In support of this, we found decreased MDSC numbers, and increased numbers of CD4⁺ T cells and natural killer T (NK-T) cells in lungs from cancer-bearing mice treated with S100A8. …”

Image_5_Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.tif by Sze Wing Wong (1617550)

“…In support of this, we found decreased MDSC numbers, and increased numbers of CD4⁺ T cells and natural killer T (NK-T) cells in lungs from cancer-bearing mice treated with S100A8. …”

Table_1_CRISPR interference for sequence-specific regulation of fibroblast growth factor receptor A in Schistosoma mansoni.xlsx by Xiaofeng Du (419414)

“…We showed that SmfgfrA repression resulted in considerable phenotypic differences in the modulated parasites compared with controls, including reduced levels of SmfgfrA transcription and decreased protein expression of SmFGFRA, a decline in EdU (thymidine analog 5-ethynyl-2’-deoxyuridine, which specifically stains schistosome stem cells) signal, and an increase in cell apoptosis. …”

Table_1_Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.xlsx by Sze Wing Wong (1617550)

“…In support of this, we found decreased MDSC numbers, and increased numbers of CD4⁺ T cells and natural killer T (NK-T) cells in lungs from cancer-bearing mice treated with S100A8. …”

Table_1_MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project.DOCX by Gilberto Vargas-Alarcón (120733)

“…Our results suggest that the rs13447720 and rs499952 polymorphisms are associated with a decreased risk of developing subclinical atherosclerosis, whereas the rs2155209 is associated with a lower subclinical atherosclerosis severity (coronary artery calcification < 100 Agatston units). …”

Image_2_Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy.JPEG by Qin Feng (147009)

“…Arctigenin pretreatment significantly alleviated the liver injury, as evidenced by biochemical and histopathological investigations, whose protective effects were comparable with Prednisone acetate and Cyclosporin A. Arctigenin pretreatment decreased the levels of IL-6 and IFN-γ, but increased the ones of IL-10. …”

Image_3_Licochalcone A Protects the Blood–Milk Barrier Integrity and Relieves the Inflammatory Response in LPS-Induced Mastitis.jpg by Wenjin Guo (361600)

“…</p><p>Result: The in vivo results showed that licochalcone A significantly decreased the histopathological impairment and the inflammatory responses, and improved integrity of blood-milk barrier. …”

Antibacterial and Antibiofilm Photodynamic Activities of Lysozyme-Au Nanoclusters/Rose Bengal Conjugates by Ichie Okamoto (10686194)

“…Photoexcited Lys-Au NCs/RB increased the effects of aPDT in a dose- and time-dependent manner. Furthermore, the photoexcited Lys-Au NCs/RB successfully decreased Streptococcus mutans biofilm formation. …”

Image_2_Licochalcone A Protects the Blood–Milk Barrier Integrity and Relieves the Inflammatory Response in LPS-Induced Mastitis.TIF by Wenjin Guo (361600)

“…</p><p>Result: The in vivo results showed that licochalcone A significantly decreased the histopathological impairment and the inflammatory responses, and improved integrity of blood-milk barrier. …”

Image_1_Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy.JPEG by Qin Feng (147009)

“…Arctigenin pretreatment significantly alleviated the liver injury, as evidenced by biochemical and histopathological investigations, whose protective effects were comparable with Prednisone acetate and Cyclosporin A. Arctigenin pretreatment decreased the levels of IL-6 and IFN-γ, but increased the ones of IL-10. …”

Table_2_Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.xlsx by Sze Wing Wong (1617550)

“…In support of this, we found decreased MDSC numbers, and increased numbers of CD4⁺ T cells and natural killer T (NK-T) cells in lungs from cancer-bearing mice treated with S100A8. …”

DataSheet_1_Discovering and Characterizing of Survivin Dominant Negative Mutants With Stronger Pro-apoptotic Activity on Cancer Cells and CSCs.doc by Wei Guo (86150)

“…The double-site mutant of survivin (TmSm34/84) showed more robust pro-apoptotic activity against A549 cells than others, and could reverse the resistance of A549 CSCs to adriamycin (ADM) (reversal index up to 7.01) by decreasing the expression levels of survivin, P-gp, and Bcl-2 while increasing cleaved caspase-3 in CSCs. …”

Image_6_Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.tif by Sze Wing Wong (1617550)

“…In support of this, we found decreased MDSC numbers, and increased numbers of CD4⁺ T cells and natural killer T (NK-T) cells in lungs from cancer-bearing mice treated with S100A8. …”