mGluR1 activity regulates cell proliferation. by Malathi Banda (505556)

“…<p><b>A. Proliferation.</b> mGluR1 overexpression significantly increased proliferation of MCF10AT1 cells compared to the control as measured by MTT assay. …”

Immunomodulation by gastrointestinal carbon black nanoparticle exposure in ovalbumin T cell receptor transgenic mice by Jason H. Fine (3109035)

“…Exposure to OVA resulted in significant increases in serum anti-OVA IgG1, anti-OVA IgM, and anti-OVA IgA antibodies relative to vehicle control. Immunophenotyping revealed a reduction in the number of OVA-specific CD4⁺T helper cells upon OVA ± CBNP^HI treatment in the spleen. …”

Source data. by Shihao Zhou (5774795)

“…Under wide-field imaging in primary somatosensory and visual cortices in mice with high labeling density (80–90%), SomaFRCaMPi exhibits up to 40% higher SNR and decreased artifactual correlation across neurons. Altogether, SomaFRCaMPi improves the accuracy and scale of neuronal activity imaging at single-neuron resolution in densely labeled brain tissues due to a 2–3-fold enhanced automated neuronal segmentation, 50% higher fraction of responsive cells, up to 2-fold higher SNR compared to jRGECO1a. …”

In vitro biophysical properties of red GECIs. by Shihao Zhou (5774795)

“…Under wide-field imaging in primary somatosensory and visual cortices in mice with high labeling density (80–90%), SomaFRCaMPi exhibits up to 40% higher SNR and decreased artifactual correlation across neurons. Altogether, SomaFRCaMPi improves the accuracy and scale of neuronal activity imaging at single-neuron resolution in densely labeled brain tissues due to a 2–3-fold enhanced automated neuronal segmentation, 50% higher fraction of responsive cells, up to 2-fold higher SNR compared to jRGECO1a. …”

Source data. by Shihao Zhou (5774795)

“…Under wide-field imaging in primary somatosensory and visual cortices in mice with high labeling density (80–90%), SomaFRCaMPi exhibits up to 40% higher SNR and decreased artifactual correlation across neurons. Altogether, SomaFRCaMPi improves the accuracy and scale of neuronal activity imaging at single-neuron resolution in densely labeled brain tissues due to a 2–3-fold enhanced automated neuronal segmentation, 50% higher fraction of responsive cells, up to 2-fold higher SNR compared to jRGECO1a. …”

Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae by Dan-hua Zhang (3997844)

“…<div><p>Bisphenol S (BPS) is widely used as a raw material in industry, resulting in its ubiquitous distribution in natural environment, including the aqueous environment. …”

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder by Comfort A. Boateng (3617120)

“…This study focused on the synthesis and evaluation of a novel series of benzothiazole analogues designed to target D₄R. …”

NRG1-II stimulates neurogenesis through ErbB4 as a cell-extrinsic signal. by Tomomi Sato (301255)

“…The approximate site of the section is shown in a lateral view in the inset. <b>E</b>. A decrease in Tyr¹¹⁶²-phosphorylated ErbB4 (pErbB4) in the OT of MO^{<i>nrg1IIE1</i>}-injected embryos (<i>nrg1IIE1</i>) compared to the control MO^{<i>nrg1IIE15m</i>}-injected embryos (<i>nrg1IIE15m</i>) at 40 hpf. …”

MMV291 disrupts actin-dependent apicoplast segregation and induces a partial delayed death phenotype. by Madeline G. Dans (14193815)

“…<b>ii</b> These images were quantified by 3 independent blind scorers, which showed a significant decrease in the normal segregation of apicoplasts between the 10 μM MMV291 and DMSO treatments, while the 5 μM MMV291 was not significant (ns). …”

Knockdown of Appa, Appb, or Prp1 results in impaired development and death of head region. A–L. by Darcy M. Kaiser (114856)

“…S3</a>). The <i>appa</i> and <i>appb</i> splice blocking (SB) MOs used above (A–H) significantly decreases detection of protein species by the antibody 22C11 (top row). …”

A randomized controlled trial and prospective cohort investigating antivenom for red-bellied black snake envenomation by Geoffrey K. Isbister (8281572)

“…</p> <p>Administration of antivenom in red-bellied black snake envenomation within 6 hours post-bite appeared to decrease the proportion of patients with myotoxicity, but a third of patients had adverse reactions.…”

MHC Ib molecule Qa-1 presents <i>Mycobacterium tuberculosis</i> peptide antigens to CD8⁺ T cells and contributes to protection against infection by Yao Bian (2820964)

“…T cells from Qa-1^-/- mice also had increased expression of inhibitory and apoptosis-associated cell surface markers such as CD94/NKG2A, KLRG1, PD-1, Fas-L, and CTLA-4. As such, they were more prone to cell death and had decreased capacity in promoting the killing of Mtb in infected macrophages. …”

Stabilization of p27^Kip1 through S140 phosphorylation is required for tumorsphere resistance to IR. by Erica K. Cassimere (3111996)

“…Differences between groups were evaluated using two-tailed Student <i>t</i> tests among replicate experiments; **P = 0.005. (E) p27S140A has a decreased half-life compared to p27WT in tumorspheres subjected to IR. …”

Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication by Ye Qiu (363315)

“…In this study, we aimed to understand the mechanism by which NFAT5 interferes with infection of Coxsackievirus B3 (CVB3), a major cause of viral myocarditis. Our initial results demonstrated that although the mRNA level of NFAT5 remained constant during CVB3 infection, NFAT5 protein level decreased because the protein was cleaved. …”

Functional regulatory mechanism of smooth muscle cell-restricted <i>LMOD1</i> coronary artery disease locus by Vivek Nanda (746334)

“…<i>LMOD1</i> knockdown results in increased proliferation and migration and decreased cell contraction in HCASMC, and immunostaining in atherosclerotic lesions in the SMC lineage tracing reporter mouse support a key role for LMOD1 in maintaining the differentiated SMC phenotype. …”

mGluR1 facilitates anchorage-independent growth. by Malathi Banda (505556)

“…<p><b>A and B. MCF10AT1 cells.</b> Cells were transduced with either with pLenti-<i>GRM1</i>, pLenti-<i>LacZ</i>, sh<i>GRM1</i>, or NS control vector and stably selected before plating in soft agar. …”

<i>Mycobacterium tuberculosis</i>-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells by Marilena P. Etna (4735113)

“…Late in infection, when miR-155 expression peaked, both the level of Atg3 and the number of LC3 puncta per cell (autophagosomes) decreased dramatically. In accordance, miR-155 silencing rescued autophagosome number in Mtb infected DC and enhanced autolysosome fusion, thereby supporting a previously unidentified role of the miR-155 as inhibitor of ATG3 expression. …”

Mutations in Mtr4 Structural Domains Reveal Their Important Role in Regulating tRNA_i^Met Turnover in <i>Saccharomyces cerevisiae</i> and Mtr4p Enzymatic Activi... by Yan Li (23143)

“…<div><p>RNA processing and turnover play important roles in the maturation, metabolism and quality control of a large variety of RNAs thereby contributing to gene expression and cellular health. …”

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations by Harsh Sheth (4843305)

“…Meta-analysis of SNPs rs2070959 and rs1105879 in <i>UGT1A6</i> gene showed interaction between aspirin use and CRC risk (<i>P</i>_interaction = 0.01 and 0.02, respectively); stratification by aspirin use showed an association for decreased CRC risk for aspirin users having a wild-type genotype (rs2070959 OR = 0.77, 95% CI = 0.68–0.86; rs1105879 OR = 0.77 95% CI = 0.69–0.86) compared to variant allele cariers. …”

Inhibition of cAMP-Dependent PKA Activates β₂-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A₂ via Raf-1/MEK/ERK and IP₃-Dependent Ca<... by M. R. Pabbidi (3560993)

“…<div><p>We previously reported in atrial myocytes that inhibition of cAMP-dependent protein kinase (PKA) by laminin (LMN)-integrin signaling activates β₂-adrenergic receptor (β₂-AR) stimulation of cytosolic phospholipase A₂ (cPLA₂). The present study sought to determine the signaling mechanisms by which inhibition of PKA activates β₂-AR stimulation of cPLA₂. …”