Image3_GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis.JPEG by Francesco Cinetto (8638674)

“…To the same extent, GSK-3 inhibition blunted the increased MMP-9 and MMP-2 activity induced by pro-fibrotic stimuli in a human lung fibroblast cell line. Moreover, the αSMA protein level, a marker of fibroblast-to-myofibroblast transition involved in fibrosis, was decreased in primary fibroblasts treated with TGFβ following GSK-3 inhibition. …”

Image1_GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis.JPEG by Francesco Cinetto (8638674)

“…To the same extent, GSK-3 inhibition blunted the increased MMP-9 and MMP-2 activity induced by pro-fibrotic stimuli in a human lung fibroblast cell line. Moreover, the αSMA protein level, a marker of fibroblast-to-myofibroblast transition involved in fibrosis, was decreased in primary fibroblasts treated with TGFβ following GSK-3 inhibition. …”

Predictors of nonfunctional arteriovenous access at hemodialysis initiation and timing of access creation: A registry-based study by Natalia Alencar de Pinho (3771187)

“…A higher percentage of AV access creation at the region level was associated with a lower rate of nonfunctional AV access (OR 0.98, 95% CI 0.98–0.99 per 1% increase). …”

Data Sheet 2_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.xlsx by Alexandra Prodea (22617710)

“…Introduction<p>Breast cancer poses a significant health problem for women worldwide due to late-stage diagnosis, toxicity of standard therapy and drug resistance. …”

Table_3_Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis.DOCX by Qiang Lu (49688)

“…Patients with pre-existing meibomian gland dysfunction (MGD) had worsened subjective symptoms of dry eye (1.31, 95% confidence interval (CI) [0.66, 1.95], P < 0.0001), a reduced tear break-up time (BUT) (−2.27, 95% CI [−2.66, −1.88], P < 0.0001), and a worse corneal fluorescein staining (CFS) score (0.75, 95% CI [0.5, 1.0], P < 0.0001) after phacoemulsification cataract surgery, whereas in the general population, the subjective symptoms score and CFS remained unchanged and BUT decreased slightly after surgery. …”

Table_1_Achieving WHO's Goal for Reducing Cesarean Section Rate in a Chinese Hospital.DOCX by Yan-Jie Ji (11736254)

Data_Sheet_9_Predictors of sequence capture in a large-scale anchored phylogenomics project.csv by Renato Nunes (5704595)

“…Sequence capture, also known as anchored hybrid enrichment, is a method to produce reduced representation libraries for NGS sequencing. …”

Table 1_The impact of climate change on medicinal plants and natural products: A scoping review.pdf by Marce Inggritha Takubessi (22671905)

“…Background<p>Medicinal plants and natural products are essential for healthcare systems globally, and, at the same time, they are a part of ecosystems and have major socioeconomic importance in many regions of the world. …”

Publication trends of research on diabetes mellitus and T cells (1997–2016): A 20-year bibliometric study by Ye Gao (338234)

“…<div><p>Introduction</p><p>Diabetes Mellitus (DM) is a huge burden for human health. Recent studies show the close relationship between DM and T cells. …”

Image1_A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells.tiff by Thomas Quast (249407)

“…In contrast to Dictyostelium amoeba, DCs are unable to decode oscillatory stimulation of soluble chemokine traveling waves into a directional response toward the wave source. …”

Table_4_A Multilevel Assessment of Plasticity in Response to High-Altitude Environment for Agama Lizards.pdf by Yin Qi (314969)

“…Both lizards were capable of acclimating to the high-altitude environment without sacrificing their performance in bite force, but they also showed high plasticity in tail display behavior by either decreasing the intensity of a specific display component (P. forsythii) or by the trade-off between display components (P. axillaris). …”

DataSheet_1_PPARG dysregulation as a potential molecular target in adrenal Cushing's syndrome.zip by Sharmilee Vetrivel (10176326)

“…Background<p>We performed a transcriptomic analysis of adrenal signaling pathways in various forms of endogenous Cushing’s syndrome (CS) to define areas of dysregulated and druggable targets.…”

A novel crosstalk between BRCA1 and poly (ADP-ribose) polymerase 1 in breast cancer by Da Li (194457)

“…Here, we showed that: (i) BRCA1 inactivation events (mutation, promoter methylation, or knockdown) were accompanied by increased PARP1 and nicotinamide adenine dinucleotide (NAD) levels, and a subsequent increase in NAD-dependent PARP1 activity in MDA-MB-231 and primary breast cancer cells; (ii) the overexpression of BRCA1 resulted in decreased PARP1 and NAD levels, and a subsequent impairment in NAD-dependent PARP1 activity in MDA-MB-231 and primary breast cancer cells; and (iii) intracellular NAD levels were largely responsible for regulating PARP1 activity in breast cancer cells, and NAD levels were positively correlated with PARP1 activity in human breast cancer specimens (R = 0.647, <i>P</i> < 0.001). …”

The effect of antibiotic prophylaxis for acute pelvic inflammatory disease after hysterosalpingography: a retrospective cohort study by Hao-Ming Li (4685770)

“…</p> <p><b>Conclusions:</b> Antibiotic prophylaxis is associated with a decreased estimated relative risk of acute PID in HSG patients. …”

Table_1_A Multilevel Assessment of Plasticity in Response to High-Altitude Environment for Agama Lizards.csv by Yin Qi (314969)

“…Both lizards were capable of acclimating to the high-altitude environment without sacrificing their performance in bite force, but they also showed high plasticity in tail display behavior by either decreasing the intensity of a specific display component (P. forsythii) or by the trade-off between display components (P. axillaris). …”

Table_1_Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study.PDF by Hayoung Choi (3279576)

“…However, compared to the normal weight without DM, the severely obese without DM and those with DM showed a 0.37 (95% CI, 0.36–0.38) and a 0.42 (95% CI, 0.36–0.48)-fold decreased risk of TB, respectively. …”

Table1_GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis.DOCX by Francesco Cinetto (8638674)

“…To the same extent, GSK-3 inhibition blunted the increased MMP-9 and MMP-2 activity induced by pro-fibrotic stimuli in a human lung fibroblast cell line. Moreover, the αSMA protein level, a marker of fibroblast-to-myofibroblast transition involved in fibrosis, was decreased in primary fibroblasts treated with TGFβ following GSK-3 inhibition. …”

The TreadWheel: A Novel Apparatus to Measure Genetic Variation in Response to Gently Induced Exercise for Drosophila by Sean Mendez (3219807)

“…<div><p>Obesity is one of the dramatic health issues affecting developed and developing nations, and exercise is a well-established intervention strategy. While exercise-by-genotype interactions have been shown in humans, overall little is known. …”

Data_Sheet_1_TNAP—a potential cytokine in the cerebral inflammation in spastic cerebral palsy.ZIP by Xiao-Kun Wang (5745635)

“…In contrast, compared with the sham rats, the model rats demonstrated a significant increase in osteopontin and proinflammatory biomarkers in both the plasma and cerebral cortex on the ischemic side whereas serum 25 hydroxyvitamin D and IL-10 were significantly decreased. …”

Supplementary Material for: Integration of Complementary Medicine in Geriatric Nursing Homes: A Prospective Comparative Observational Study by figshare admin karger (2628495)

“…Introduction A healthy lifestyle is considered to be an important factor for healthy aging. …”