Transmission electronic microscopy reveals that the hepatocytes in the SO group have a clear and complete structure, nuclei are placed in the middle, nucleolus and nuclear membrane... by Fang Xie (103933)

“…<p>The ridges are clear (8000×) (A). Hepatocytes in the SO group have a tight junction and normal cholangiole microvilli can be seen (25,000×) (B). …”

Cryo-EM structures of Map1 bound to ribosomes via expansion segment ES27a. by Alexandra G. Knorr (15333351)

“…<p>(<b>A</b>) Concentrated eluate obtained from Map1-TAP affinity purification shown on a 12% Nu-PAGE. …”

Treatment with a fecal microbiota transplant following spinal cord injury reduced anxiety-like behaviour. by Emma K. A. Schmidt (8307642)

“…<p>Animals were tested in the elevated plus maze 3 weeks following surgeries. <b>(A)</b> Representative images from the motion tracking software used to analyze the elevated plus maze. …”

PRMT5 stabilizes vCyclin protein expression in a manner dependent on its methyltransferase activity. by Danping Niu (10912688)

“…<p>(A-B) Effect of PRMT5 on vCyclin expression. First, HEK293T cells were cotransfected with fixed amounts of vCyclin expression plasmid and increasing amounts of PRMT5 expression plasmids. …”

Why Do People Migrate Irregularly? Evidence From a Lab-in-the-Field Experiment in West Africa by Tijan Bah (18888085)

“…In this context, our experimental results show that providing potential migrants with official numbers on the probability of getting a legal residence permit decreases their likelihood of migration by 2.88 percentage points (pp), while information on the death risk of migrating increases their likelihood of migration by 2.29 pp—although the official numbers should be regarded as a lower bound to actual mortality. …”

Ccr7 inhibits β-catenin activity via a Gsk3β-indepenedent mechanism. by Shu-Yu Wu (129447)

“…Compared to control (a, d), <i>ccr7</i> RNA overexpressing blastulae showed strongly decreased (b, e), while MO1-<i>ccr7</i> injected blastulae showed increased, ΔNβ-catenin-GFP signal (c, f). …”

CNNM4 but not SLC41A1 stimulates TRPM7-mediated divalent cation entry. by Zhiyong Bai (259036)

“…<i>n</i> = 100.* indicates a <i>p</i>-value of less than 0.05. <b>(C)</b> Separate control experiments were performed using the Mag-Fura-2 dye to show that the magnesium levels of 293-TRPM7 cells expressing CNNM4 as well as SLC41A1 decreased compared to 293-TRPM7 cells alone. …”

Bistable pattern formation by JNK/AP-1 and JAK/STAT signaling by a mutual repression motif. by Janhvi Jaiswal (14266407)

“…<b>(C)</b> The steady-state patterns are classified as “simple” bistable when JAK/STAT decreases and JNK/AP-1 increases in space with a relative change greater than 10% (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001665#sec011" target="_blank">Materials and methods</a> for details). …”

Effect of sodium bicarbonate on prolonged running performance: A randomized, double-blind, cross-over study by Tanja Freis (4348774)

“…</p><p>Trial registration</p><p>German Clinical Trials Register (DRKS) <a href="https://clinicaltrials.gov/ct2/show/DRKS00011284" target="_blank">DRKS00011284</a>.…”

A model for SOX9 control of differentiation phase–specific gene expression in growth plate chondrocytes. by Victor Y. L. Leung (198251)

“…Concomitantly <i>Col2a1</i> expression is markedly decreased. SOX9 therefore controls differentiation-phase specific gene expression in chondrocytes through direct and indirect mechanisms. …”

The fraction of the force distribution with a magnitude of force <i>f</i> greater than or equal to 0.01<i>F</i>_<i>s</i>, as a function of the diffusion constant for the... by Niranjan Sarpangala (12837428)

“…The fraction increases as a function of <i>n</i> for rigid cargo but decreases for lipid cargo. …”

WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism by Li-Ting Wang (480568)

“…In fact, WLS was discovered to integrate a protein complex in N-glycan-dependent and WLS domain-selective manners, comprising ER stress sensors and lectin chaperones. …”

Image_1_Preferential Effects of Cariprazine on Counteracting the Disruption of Social Interaction and Decrease in Extracellular Dopamine Levels Induced by the Dopamine D3 Receptor... by Jan Kehr (8292456)

“…As measured by microdialysis, the highest dose of cariprazine prevented a PD-induced decrease in DA levels (40–80 min post PD dose) in the medial prefrontal cortex (mPFC), whereas aripiprazole did not have a significant effect. …”

Table_1_Preferential Effects of Cariprazine on Counteracting the Disruption of Social Interaction and Decrease in Extracellular Dopamine Levels Induced by the Dopamine D3 Receptor... by Jan Kehr (8292456)

“…As measured by microdialysis, the highest dose of cariprazine prevented a PD-induced decrease in DA levels (40–80 min post PD dose) in the medial prefrontal cortex (mPFC), whereas aripiprazole did not have a significant effect. …”

Identification of <em>IGF1</em>, <em>SLC4A4</em>, <em>WWOX</em>, and <em>SFMBT1</em> as Hypertension Susceptibility Genes in Han Chinese with a Genome-Wide Gene-Based Association S... by Hsin-Chou Yang (19577)

“…<em>SLC4A4</em>, which encodes the electrogenic sodium bicarbonate cotransporter 1, is associated with decreased body weight/size and abnormal ion homeostasis in mice. …”

Reductive C–C Coupling from Molecular Au(I) Hydrocarbyl Complexes: A Mechanistic Study by Juan Miranda-Pizarro (10105156)

“…The rate of ethane formation from [Au₂(μ-CH₃)­(PMe₂Ar′)₂]­[NTf₂] increases as the steric bulk of the phosphine substituent Ar′ decreases. Monitoring the rate of ethane elimination reactions by multinuclear NMR spectroscopy provides evidence for a second-order dependence on the gem-digold methyl complexes. …”

Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism by Tzu-Yin Lee (4518055)

“…<i>atg5</i>^−/− platelets also exhibited a lower aggregation in response to agonists, and platelet-specific <i>atg5</i>^−/− mice exhibited delayed thrombus formation in mesenteric microvessles and decreased mortality rate due to pulmonary thrombosis. …”

dAβ expression alters memory only when associated with APPL partial loss-of-function. by Isabelle Bourdet (783402)

“…<i>Appl</i>^<i>d</i>/+;<i>MBSw</i>/<i>dAβ</i> flies display a score significantly decreased compared to the controls (Newman-Keuls <i>post-hoc</i>, <i>Appl</i>^<i>d</i>/+;<i>MBSw</i>/<i>dAβ</i> vs <i>Appl</i>^<i>d</i><i>/+;MBSw/+ **p</i> < 0.01, <i>Appl</i>^<i>d</i>/+; <i>MBSw</i>/<i>dAβ</i> vs <i>+</i>/<i>dAβ ***p</i> < 0.001). …”

A proposed framework for the hypothesized pathogenesis of lung abnormality among individuals with HIV and pneumonia co-infection. by Breanne M. Head (8120231)

“…HIV alters the immune environment and affects the host response [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0226347#pone.0226347.ref067" target="_blank">67</a>], therefore it is hypothesized that HIV-infected individuals who contract pneumonia will have a decreased ability to clear the invading pathogen, leading to increased fibroblast activation, extracellular matrix deposition and tissue remodeling resulting in impaired gas exchange and greater lung abnormality (top right panel).…”

SPR4-peptide induces a dramatic increase in fat mass/weight in HYP and WT mice. by Lesya V. Zelenchuk (566168)

“…<p>Dual Energy X-ray Absorptiometry (DEXA) measurements using a Lunar PIXImus system were carried out as described previously and discussed in methods <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0097326#pone.0097326-David2" target="_blank">[140]</a>. …”