Change of SMAD4 after TGFβ inhibitor /activator treatment. by Jingping Ge (636557)

“…Protein levels were measured by Western blot analysis. A) Decrease of total p-SMAD2 after SB431542 treatment in all iPSCs, and increase of p-SMAD2 in both DBA iPSCs after the TGFβ1 treatment. …”

FOXO3a mediates the downregulation of GR induced by chronic exposure to GCs. by Shi-Ying Yuan (2937669)

“…<p>(A) Representative western blot images and summarized data showing the decreased expression of LKB1 (A) and the inhibitory phosphorylation of FOXO3a-Thr32 (B) in cultured astrocytes (n = 6 for each group). …”

Effect of heat stress on N1S1 and AS30D cell viability and clonogenic survival. by Scott M. Thompson (231230)

Vitamin a supplementation during pregnancy in shaping child growth outcomes: A meta-analysis by Guiling Ma (384878)

“…Fifty-five studies were included in this meta-analysis (426,098 pregnancies). Vitamin A decreased risk of preterm birth by 9% in MH-RCT (<i>P</i> < 0.001), by 62% in MH-OS (<i>P</i> = 0.029), by 10% in MC-RCT (<i>P</i> = 0.089); decreased LBW by 24% in MC-RCT (<i>P</i> = 0.032); increased neonatal weight in MC-RCT (SMD 0.96; <i>P</i> = 0.051). …”

p38MAPK, ERK and PI3K Signaling Pathways Are Involved in C5a-Primed Neutrophils for ANCA-Mediated Activation by Jian Hao (160736)

“…For PR3-ANCA-positive IgG, the MFI value increased in C5a-primed neutrophils, which decreased upon pre-incubation with above-mentioned inhibitors. …”

Table1_Severe gastrointestinal involvement in pediatric IgA vasculitis: a retrospective single-center cohort study in China.xlsx by Yifan Li (327507)

“…Objectives<p>The study aimed to describe the characteristics of gastrointestinal (GI) involvement in a cohort of hospitalized children with IgA vasculitis (IgAV) in China.…”

Data_Sheet_1_The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis.PDF by Kelly F. Paton (3934061)

“…In the experimental autoimmune encephalomyelitis model, we found that EOM SalB (0.1–0.3 mg/kg) effectively decreased disease severity in a KOR-dependent manner and led to a greater number of animals in recovery compared to U50,488 treatment. …”

c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis by Ryu Katsumata (133006)

“…The survival of G93A mice was improved by oral administration of dasatinib, which also decreased c-Abl phosphorylation, inactivated caspase-3, and improved the innervation status of neuromuscular junctions. …”

Data_Sheet_1_Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.PDF by Yanhua Zhang (356457)

“…In this study, we examined the effects of trichostatin A (TSA), a HDACi, on eosinophilic meningitis induced by A. cantonensis in mice. …”

Table_1_Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.DOCX by Yanhua Zhang (356457)

“…In this study, we examined the effects of trichostatin A (TSA), a HDACi, on eosinophilic meningitis induced by A. cantonensis in mice. …”

Monitoring and understanding chlorophyll-a concentration changes in lakes in northeastern China using MERIS and OLCI satellite data by Lu Zhang (50563)

“…During the study period, 11 lakes exhibited statistically significant increases in Chl-a concentrations (<i>p</i> < 0.05), and 3 lakes showed significantly decreasing trends. …”

Table_3_Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.DOCX by Yanhua Zhang (356457)

“…In this study, we examined the effects of trichostatin A (TSA), a HDACi, on eosinophilic meningitis induced by A. cantonensis in mice. …”

Supplementary Material for: Nrf2- and Bach1 May Play a Role in the Modulation of Ultraviolet A-Induced Oxidative Stress by Acetyl-11-Keto-β-Boswellic Acid in Skin Keratinocytes by Yang S. (3704074)

“…<b><i>Results:</i></b> AKBA reduces UVA irradiation-induced cell viability loss, accompanied by a decreased production of UVA-induced ROS, decreased malondialdehyde, and increased superoxide dismutase expression. …”

Table_2_Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.DOCX by Yanhua Zhang (356457)

“…In this study, we examined the effects of trichostatin A (TSA), a HDACi, on eosinophilic meningitis induced by A. cantonensis in mice. …”

GABA_A receptor-expressing neurons promote consumption in <i>Drosophila melanogaster</i> by Samantha K. Cheung (3897748)

“…Acute activation of these neurons is sufficient to drive consumption of appetitive substances and non-appetitive substances and acute silencing of these neurons decreases consumption. Taken together, these studies identify GABA_A receptor-expressing neurons that promote <i>Drosophila</i> ingestive behavior and provide insight into feeding regulation.…”

Reducing age bias in decision analyses of anticoagulation for patients with nonvalvular atrial fibrillation – A microsimulation study by Matthew A. Pappas (5504363)

“…<div><p>Background</p><p>Anticoagulation decreases a patient’s risk of ischemic stroke and increases the risk of hemorrhage. …”

Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes with Alirocumab: Post-Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial by Gregory G. Schwartz (20599125)

“…However, in logistic regression, decreased lipoprotein(a) and LDL cholesterol on alirocumab were independent, opposite predictors of NOD. …”

Drug-induced decrease of cell anisotropy reduces pattern fidelity. by Camille Curantz (7456499)

“…<b>(B)</b> Quantifications of primordia spacing variability on phalloïdin-stained control flat skins (explant; triangles) and LatA-treated cultured explants (+LatA; squares) of Japanese quail embryos showed that LatA treatment caused a significant decrease in pattern fidelity at condensation stage (explants, <i>n</i> = 9; +LatA, <i>n</i> = 9; unpaired 2-tailed <i>t</i> test; <i>p</i> = 0.0233) and differentiation stage (explants, <i>n</i> = 8; +LatA, <i>n</i> = 9; <i>p</i> = 0.002). …”

Parametric Analysis of Gene Set Enrichment identifies Gene Ontology (GO) terms changed in gastrocnemius muscle of 13-month old D257A mice as compared to 13-month old WT mice. by Asimina Hiona (246175)

“…(D) Genes listed within the GO term “electron transport chain” (<i>Z</i>-score = −8.89; p<0.0001) whose expression level significantly (p<0.01) increased (yellow) or decreased (blue) in D257A mice.</p>…”

Table_2_A Small Molecule Inhibitor of CTP Synthetase Identified by Differential Activity on a Bacillus subtilis Mutant Deficient in Class A Penicillin-Binding Proteins.pdf by Kaveh Emami (320085)

“…Two of the three mutant proteins purified showed decreased sensitivity to IQC in vitro. Finally, inhibition by IQC was rescued by addition of cytidine but not uridine to the growth medium, consistent with the notion that IQC acts by reducing the synthesis of CTP or a related compound. …”