PIM2 Kinase Is Induced by Cisplatin in Ovarian Cancer Cells and Limits Drug Efficacy by Daniele Musiani (1725541)

“…Bioinformatic analysis revealed enrichment in linear phosphorylation motifs predicted to be targets of p38MAPK, CDK2, and PIM2. …”

The Impact of Stimulus Valence and Emotion Regulation on Sustained Brain Activation: Task-Rest Switching in Emotion by Jan-Peter Lamke (544728)

“…<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093098#s3" target="_blank">Results</a> showed that the regulation of negative emotion led to reverse task-rest interactions (decreased activation during stimulation but increased activation during fixation) in the amygdala as well as in visual cortex regions and to concordant task-rest interactions (increased activation during both, stimulation and fixation) in the dorsolateral prefrontal cortex as well as in a number of brain regions at the intersection of the default mode and the dorsal attention networks. …”

Compact Conformations of Human Protein Disulfide Isomerase by Shang Yang (607468)

“…<div><p>Protein disulfide isomerase (PDI) composed of four thioredoxin-like domains <b>a</b>, <b>b</b>, <b>b'</b>, and <b>a'</b>, is a key enzyme catalyzing oxidative protein folding in the endoplasmic reticulum. …”

Deciphering Proteomic Signatures of Early Diapause in <em>Nasonia</em> by Florian Wolschin (34350)

“…Only few potentially diapause-specific proteins were identified suggesting that diapause in <em>Nasonia</em> relies to a large extent on a modulation of pre-existing pathways. …”

Video_3_Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.WMV by Danila Vella (7477892)

“…In particular, in the analyzed models, the impairment in contractility determined a decrease in SSR of about 50%, whilst the chamber pathological dilatation contributed to a 30% reduction, indicating increased risk of clot formation. …”

Video_4_Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.WMV by Danila Vella (7477892)

“…In particular, in the analyzed models, the impairment in contractility determined a decrease in SSR of about 50%, whilst the chamber pathological dilatation contributed to a 30% reduction, indicating increased risk of clot formation. …”

Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study by Sebastian Okser (240648)

“…The area under the receiver operating characteristic curve (AUC) was used to evaluate the predictive value of the variants, and cross-validation was used to assess how well the predictive models will generalize to other subsets of subjects. By means of our predictive modeling framework with machine learning-based SNP selection, we could improve the prediction of the extreme classes of atherosclerosis risk and progression over a 6-year period (average AUC 0.844 and 0.761), compared to that of using conventional cardiovascular risk factors alone (average AUC 0.741 and 0.629), or when combined with the statistically significant variants (average AUC 0.762 and 0.651). …”

Supplementary Material for: AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3 by Liebisch M. (9308795)

“…To determine the meaning of EZH2 suppression, EZH2 activity was inhibited by incubating the cells with the pharmacological methyltransferase inhibitor 3-deazaneplanocin A; EZH2 expression was repressed with siRNA. mRNA expression was analyzed with real-time PCR, and protein expression with Western blot. …”

Video_2_Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.WMV by Danila Vella (7477892)

“…In particular, in the analyzed models, the impairment in contractility determined a decrease in SSR of about 50%, whilst the chamber pathological dilatation contributed to a 30% reduction, indicating increased risk of clot formation. …”

LbL-assembled gentamicin delivery system for PMMA bone cements to prolong antimicrobial activity by Yazan Al Thaher (6083240)

“…One of the shortcomings of the current generation of ALBCs is that the antibiotic release profile is characterized by a burst over the first few hours followed by a sharp decrease in rate for the following several days (often below minimum inhibitory concentration (MIC)), and, finally, exhaustion (after, typically, ~ 20 d). …”

Depleted pool of oNSCs and diminished neurogenesis in embryonic <i>BAF155</i>cKO OE. by Christina Bachmann (3111933)

“…(G–L) Statistical quantification of panels A–F is shown. Note the decrease in the number of Sox2⁺ oNSCs at both E10 and E13.5. …”

Sleep-related changes in breathing. by Stefano Bastianini (130236)

“…(C) Representative tracing (plethysmographic ventilator signal, VENT; electroencephalogram, EEG; electromyogram, EMG) during a transition from N to R in a DM mouse. The decrease in T_TOT during R is evident from the occurrence of more closely spaced deflections of the VENT signal with individual breaths. …”

Data_Sheet_1_Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.PDF by Danila Vella (7477892)

“…In particular, in the analyzed models, the impairment in contractility determined a decrease in SSR of about 50%, whilst the chamber pathological dilatation contributed to a 30% reduction, indicating increased risk of clot formation. …”

Video_1_Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.WMV by Danila Vella (7477892)

“…In particular, in the analyzed models, the impairment in contractility determined a decrease in SSR of about 50%, whilst the chamber pathological dilatation contributed to a 30% reduction, indicating increased risk of clot formation. …”

Data Supplement from Epigenetic Targeting of Ovarian Cancer Stem Cells by Yinu Wang (14844702)

“…Supplemental Figure S8. SGI-110 decreases expression of ALDH1A1 and DNMT isoforms in OC. …”

Light Microscopic Analysis of the Cerebral Cortex. by Hiroaki Nabeka (485031)

“…Effects of the PS18 treatment on viable neuronal density in the hippocampal CA1 region in rats that received a subcutaneous injection of 12 mg/kg KA (E). Four PS18 treatments following a KA injection decreased the number of injured neurons in a dose-dependent manner in KA-injected rats compared with PBS-treated KA-injected rats. …”

In vivo PrP^C expression in AONYS/siRNA-treated mice. by Sylvain Lehmann (372399)

“…The C+ lane corresponds to a brain homogenate of untreated mice. A decrease of PrP^C was apparent in siPrP treated mice. …”

DataSheet1_Isothermal crystallization kinetics in bulk of olefin-based multiblock copolymers.pdf by Gaia Urciuoli (11725469)

“…The crystallization half time of the samples increases with increase of M_n and, for each sample, its logarithm increases linearly with a decrease of the undercooling by a factor of -0.155/°C, for the samples 1–4 and −0.031/°C, for the sample 5. …”

Predictive outcomes for major and minor NKH human neurogenic mutations. by Joseph Farris (8856620)

“…The model is based on the following four assumptions. i.WMMS is linearly proportionate to neurological disease (y = 0.76*x—2.5; r² 0.9, based on findings of <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009307#pgen.1009307.g006" target="_blank">Fig 6B</a>) ii. …”

Effect of Trk receptor inhibitor on <i>in vivo</i> tumor growth of MES-SA/Dx5 xenografts in athymic nude mice. by Kenichi Makino (149077)

“…Tumor volume on the first day of treatment was expressed as a relative tumor volume of 1. <i>Points</i>, mean; <i>bars</i>, SE. *, <i>P</i><0.05 vs. control. …”