Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021 by Austin, Carter

“…In the same period, PUV increased in central Europe, eastern Europe, and central Asia by 116·1% (8·0–218·2). Our forecasts predict a continued global decline in HIV incidence and mortality, with the number of people living with HIV peaking at 44·4 million (40·7–49·8) by 2039, followed by a gradual decrease. …”
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Image_3_Cerebral Microbleeds, Cerebrospinal Fluid, and Neuroimaging Markers in Clinical Subtypes of Alzheimer's Disease.TIF by Masaki Ikeda (397115)

“…We then examined the levels of cerebrospinal fluid (CSF) biomarkers [Aβ1-42, Aβ1-40, Aβ1-38, phosphorylated tau 181 (P-Tau), total tau (T-Tau), neurofilament light chain (NFL), and chitinase 3-like 1 protein (YKL-40)], analyzed the number and localization of CMBs, and measured the cerebral blood flow (CBF) volume by ^99mTc-ethyl cysteinate dimer single photon emission computerized tomography (^99mTc ECD-SPECT), as well as the mean cortical standard uptake value ratio by ¹¹C-labeled Pittsburgh Compound B-positron emission tomography (¹¹C PiB-PET). …”

Image_2_Cerebral Microbleeds, Cerebrospinal Fluid, and Neuroimaging Markers in Clinical Subtypes of Alzheimer's Disease.TIF by Masaki Ikeda (397115)

“…We then examined the levels of cerebrospinal fluid (CSF) biomarkers [Aβ1-42, Aβ1-40, Aβ1-38, phosphorylated tau 181 (P-Tau), total tau (T-Tau), neurofilament light chain (NFL), and chitinase 3-like 1 protein (YKL-40)], analyzed the number and localization of CMBs, and measured the cerebral blood flow (CBF) volume by ^99mTc-ethyl cysteinate dimer single photon emission computerized tomography (^99mTc ECD-SPECT), as well as the mean cortical standard uptake value ratio by ¹¹C-labeled Pittsburgh Compound B-positron emission tomography (¹¹C PiB-PET). …”

Image_1_Cerebral Microbleeds, Cerebrospinal Fluid, and Neuroimaging Markers in Clinical Subtypes of Alzheimer's Disease.TIF by Masaki Ikeda (397115)

“…We then examined the levels of cerebrospinal fluid (CSF) biomarkers [Aβ1-42, Aβ1-40, Aβ1-38, phosphorylated tau 181 (P-Tau), total tau (T-Tau), neurofilament light chain (NFL), and chitinase 3-like 1 protein (YKL-40)], analyzed the number and localization of CMBs, and measured the cerebral blood flow (CBF) volume by ^99mTc-ethyl cysteinate dimer single photon emission computerized tomography (^99mTc ECD-SPECT), as well as the mean cortical standard uptake value ratio by ¹¹C-labeled Pittsburgh Compound B-positron emission tomography (¹¹C PiB-PET). …”

<i>eipr-1</i> mutants have defects in trafficking dense-core vesicle cargos. by Irini Topalidou (2794261)

“…<p>(A) Left: representative images of NLP-21::Venus (<i>nuIs183</i> transgene) fluorescence in motor neuron axons of the dorsal nerve cord. …”

DataSheet2_Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption.pdf by Timothy D. Majarian (6269588)

“…In gene expression studies, this allele is associated with decreased expression of ALDH2, which is part of a major oxidative pathway. …”

DataSheet1_Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption.pdf by Timothy D. Majarian (6269588)

“…In gene expression studies, this allele is associated with decreased expression of ALDH2, which is part of a major oxidative pathway. …”

Bacterial PAMPs (LPS) and cytokines (IFNγ) increase macrophage phagocytosis and cell elasticity. by Naimish R. Patel (136156)

“…</b> Macrophage elasticity is decreased by actin polymerization inhibitor. Optical Magnetic Twisting Cytometry (OMTC) measurement of RAW macrophages cultured on more rigid (150 kPa) surface and treated with the myosin inhibitor blebbistatin (Bleb, 50 µM) or the actin polymerization inhibitor latrunculin A (Lat A, 1 µM). …”

Neurotensin activates orexin neurons. by Naoki Furutani (169799)

“…Neurons were current-clamped and the current was stepped from –240 pA to +280 pA (with increments of 40 pA with a duration of 100 ms). …”

Back-propagating APs produce robust ΔCa²⁺ in distal dendrites of the NRT neurons. by Patrick Chausson (449010)

“…<p>A. Top traces: ΔCa²⁺ recorded in response to a somatically evoked burst of 45 APs at 10 Hz (left trace). …”

DataSheet1_Evaluation of Potential Herb-Drug Interactions Between Shengmai Injection and Losartan Potassium in Rat and In Vitro.PDF by Zhenchao Niu (12253952)

“…SMI affected the pharmacokinetic properties of LOS by decreasing the elimination of LOS. These effects might partly be attributed to the inhibition of the activities of CYP3A4, CYP2C9, and of the drug transporters (P-gp, BCRP, and OATP1B1) by SMI, which need further scrutiny.…”

Mapping the shape and steepness of gradients of transcription factor expression in 3D. by Matthew French (13007466)

“…Solid lines indicate the fit of a non-parametric multiple regression curve and shading indicates 0.05–0.95 confidence intervals calculated as (mean ± 1.96 * (<i>σ</i>/(√<i>n</i>)). …”

MUS81 causes DNA double-strand breaks upon Chk1 inhibition that result in cell death. by Josep V. Forment (119177)

“…<p><i>A.</i> AZD7762 treatment produces γH2AX in replicating cells. …”

IL6/STAT3 modulates estrogen-induced GREB1 transcriptional activity in breast cancer cells. by Mingli Liu (304361)

“…The samples were treated with E2 as indicated before assaying for luciferase activity. As shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046410#pone-0046410-g005" target="_blank">Figure 5G</a>, STAT3-C decreases GREB1 transcription by approximately 39%. …”

Table_2_17β-Estradiol Attenuates Neuropathic Pain Caused by Spared Nerve Injury by Upregulating CIC-3 in the Dorsal Root Ganglion of Ovariectomized Rats.XLSX by Zhen-Zhen Xu (2126308)

“…<p>17β-estradiol plays a role in pain sensitivity, analgesic drug efficacy, and neuropathic pain prevalence, but the underlying mechanisms remain unclear. …”

Image_10_17β-Estradiol Attenuates Neuropathic Pain Caused by Spared Nerve Injury by Upregulating CIC-3 in the Dorsal Root Ganglion of Ovariectomized Rats.TIF by Zhen-Zhen Xu (2126308)

“…<p>17β-estradiol plays a role in pain sensitivity, analgesic drug efficacy, and neuropathic pain prevalence, but the underlying mechanisms remain unclear. …”

Image_8_17β-Estradiol Attenuates Neuropathic Pain Caused by Spared Nerve Injury by Upregulating CIC-3 in the Dorsal Root Ganglion of Ovariectomized Rats.JPEG by Zhen-Zhen Xu (2126308)

“…<p>17β-estradiol plays a role in pain sensitivity, analgesic drug efficacy, and neuropathic pain prevalence, but the underlying mechanisms remain unclear. …”

Image_9_17β-Estradiol Attenuates Neuropathic Pain Caused by Spared Nerve Injury by Upregulating CIC-3 in the Dorsal Root Ganglion of Ovariectomized Rats.JPEG by Zhen-Zhen Xu (2126308)

“…<p>17β-estradiol plays a role in pain sensitivity, analgesic drug efficacy, and neuropathic pain prevalence, but the underlying mechanisms remain unclear. …”

Image_11_17β-Estradiol Attenuates Neuropathic Pain Caused by Spared Nerve Injury by Upregulating CIC-3 in the Dorsal Root Ganglion of Ovariectomized Rats.TIF by Zhen-Zhen Xu (2126308)

“…<p>17β-estradiol plays a role in pain sensitivity, analgesic drug efficacy, and neuropathic pain prevalence, but the underlying mechanisms remain unclear. …”

Table_3_Differential Expression Profile of microRNAs and Tight Junction in the Lung Tissues of Rat With Mitomycin-C-Induced Pulmonary Veno-Occlusive Disease.docx by Qing Song (77132)

“…The expression of GCN2 was significantly decreased (P < 0.05). A total of 106 differentially expressed miRNAs were identified. …”