A Measure for σ-Donor and π-Acceptor Properties of Diiminepyridine-Type Ligands by Di Zhu (1450108)

“…The assumption of a linear energy relation Δ<i>E</i>_stab(F,L) = α_Fσ_L + β_Fπ_L for the relative binding energy of fragment F to ligand L was used to derive scales for ligand parameters σ_L and π_L representing the σ-donor and π-acceptor qualities of these ligands. …”

Integrating Electrochemical and Colorimetric Sensors with a Webcam Readout for Multiple Gas Detection by Xingcai Qin (2201686)

“…The sacrificed Ag layer used in the bipolar electrochemical (EC) sensor was recycled from CD, which further decreased the sensor cost and supplied a new way of CD recycling. …”

Spatial Characteristics of Tree Diameter Distributions in a Temperate Old-Growth Forest by Chunyu Zhang (118320)

“…At scales exceeding the peak distance, the percentage of species showing significant <i>dbh</i> suppression decreases sharply with increasing distances. The evidence from this large observational study shows that some of the variation of the spatial characteristics of tree diameters is related variations of topography and soil chemistry. …”

Table 1_Metformin for neurocognitive dysfunction in schizophrenia: a systematic review.docx by Zhen-Juan Qin (16712376)

“…Adverse events were reported in two RCTs, with inconsistent findings on decreased appetite and diarrhea. Other adverse events and discontinuation rates were comparable between groups.…”

A Feedback Loop between Dynamin and Actin Recruitment during Clathrin-Mediated Endocytosis by Marcus J. Taylor (173337)

“…Conversely, acute ablation of actin dynamics using latrunculin-B led to a ∼50% decrease in the incidence of scission, an ∼50% decrease in the amplitude of dynamin recruitment, and abolished actin and N-BAR recruitment to scission events. …”

Power to detect a minimum 30% reduction in population size occurring by year of monitoring. by Eric Peter Vanderduys (18196180)

A low threshold K⁺ current determines the long refractory period. by Javier Nogueira (348174)

“…B) Paired pulse stimulation with sub-threshold stimuli show that depolarization leads to an hyperpolarization after the end of the pulse (red arrow)and a decrease of excitability of the neuron evidenced by the reduction depolarization peak in a constant amplitude test pulse (blue arrow). …”

Temporal Patterns of Medications Dispensed to Children and Adolescents in a National Insured Population by Karen L. Olson (149953)

“…Contraceptives accounted for a large proportion of dispensed medication to older teenage girls. …”

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor by Renato Ferreira de Freitas (1399675)

“…Here, by deconstructing potent PRMT inhibitors, we find that chemical moieties occupying the substrate arginine-binding site can act as efficient fragment inhibitors. Screening a fragment library against PRMT6 produced numerous hits, including a 300 nM inhibitor (ligand efficiency of 0.56) that decreased global histone 3 arginine 2 methylation in cells, and can serve as a warhead for the development of PRMT chemical probes.…”

ACY-1083 preserves epithelial plasticity phenotypes induced by TNF. by Jenny Horndahl (10478701)

Blockade of GKAP degradation prevents Aβ-induced actin cytoskeleton remodeling. by Francesco Roselli (211670)

“…Likewise, Aβ caused a marked decrease in F-actin accumulation in spines (61.5±6.7% of control, p<0.05), whereas roscovitine pre-treatment largely blocked this effect (90.0±15.1%, Rosco+Aβ vs Aβ alone). …”

Buckling and Torsional Instabilities of a Nanoscale Biological Rope Bound to an Elastic Substrate by Chris Peacock (9437559)

“…In addition, in ambient conditions, the sine wave response coexists with the formation of loops along the length of the fibrils, as observed for the torsional instability of a twisted filament when tension is decreased. This work provides direct evidence that single collagen fibrils are highly susceptible to axial compression because of their helical supermolecular structure. …”

Safety profiles of tetracycline-class drugs: a pharmacovigilance analysis of the FAERS database by Xu Zhang (49484)

“…However, the safety of third-generation tetracycline in children requires additional validation through a large-scale prospective study.</p>…”

Serotonin modulates L2 neuron visually induced calcium transient kinetics. by Maureen M. Sampson (9322886)

“…(<b>D</b>) Response to light flashes. When a light flash was presented in control experiments, L2 cells responded with a decrease in GCaMP signal followed by a large sustained increase in the GCaMP6 signal. …”

SSD - a free software for designing multimeric mono-, bi- and trivalent shRNAs by Gabriel José de Carli (8526942)

“…RT-qPCR analysis revealed that our molecule promoted a decrease in more than 50% of the target mRNA, in a dose-dependent manner, when compared to the control group. …”

Catalytic Conversion of a Chitin-Derived Sugar Alcohol to an Amide-Containing Isosorbide Analog by Takuya Sagawa (4996418)

“…Instead, a large amount of a super strong acid, CF₃SO₃H, under vacuum conditions is required to produce ADI from ADS. …”

Single-Component Conductors: A Sturdy Electronic Structure Generated by Bulky Substituents by Agathe Filatre-Furcate (1762963)

“…This system is weakly conducting at ambient pressure (5 S·cm^–1), and both transport and optical measurements evidence a slowly decreasing energy gap under applied pressure with a regime change around 1.5 GPa. …”

Single-Metallic Thermoresponsive Coordination Network as a Dual-Parametric Luminescent Thermometer by Kedar Bahadur Thapa (11166857)

“…The single-metallic coordination networks (CNs), simultaneously exhibiting temperature-dependent lifetime (TDLT) and emission band shift (TDEBS), are desirable for application in luminescent thermometers with high accuracy and reliability in a large temperature range. Nonetheless, up to date, there are no reports on such kinds of materials due to the lack of in-depth understanding of the origin of TDLT and TDEBS at a molecule level, being critical for exploiting a universal approach to design a dual-parametric CN phosphorescent thermometer (CN-PT). …”

Illustration of three simple scenarios of association between genotype and a bivariate phenotype. by Matthew Stephens (3815)

“…Each point represents an individual, colored according to their genotype (0, 1 or 2 copies of the minor allele). A) A variant associated with <i>weight</i> but not <i>height</i>. …”

Single-Metallic Thermoresponsive Coordination Network as a Dual-Parametric Luminescent Thermometer by Kedar Bahadur Thapa (11166857)

“…The single-metallic coordination networks (CNs), simultaneously exhibiting temperature-dependent lifetime (TDLT) and emission band shift (TDEBS), are desirable for application in luminescent thermometers with high accuracy and reliability in a large temperature range. Nonetheless, up to date, there are no reports on such kinds of materials due to the lack of in-depth understanding of the origin of TDLT and TDEBS at a molecule level, being critical for exploiting a universal approach to design a dual-parametric CN phosphorescent thermometer (CN-PT). …”