Discovery of Novel Biomarker Candidates for Liver Fibrosis in Hepatitis C Patients: A Preliminary Study by Bevin Gangadharan (156036)

“…These markers will be further validated using a large clinical cohort.</p> <h3>Conclusions/Significance</h3><p>This study identifies 20 novel fibrosis biomarker candidates. …”

The relationship between diabetes and colorectal cancer prognosis: A meta-analysis based on the cohort studies by Bo Zhu (118038)

“…<div><p>Introduction</p><p>Though a meta-analysis reported the effect of diabetes on colorectal prognosis in 2013, a series of large-scale long-term cohort studies has comprehensively reported the outcome effect estimates on the relationship between diabetes and colorectal prognosis, and their results were still consistent.…”

DNMT3L Is a Regulator of X Chromosome Compaction and Post-Meiotic Gene Transcription by Natasha M. Zamudio (225855)

“…Consistent with the mRNA data, we have localized DNMT3L within spermatids and sperm and shown that the loss of a <em>Dnmt3L</em> allele results in a decreased DNMT3L content within sperm. …”

Searching for glycomic biomarkers for predicting resilience and vulnerability in a rat model of posttraumatic stress disorder by Csilla Lea Fazekas (9282098)

“…Traumatic stress induced a shift from large, elaborate N-glycans toward simpler neutral structures in the plasma of all traumatized animals and specifically in the prefrontal cortex of vulnerable rats. …”

Sample details and genome coverage (n = 1,409). by Mathieu Vanhove (3298326)

“…In the five-year study period, we observed a decrease in frequency of a mutation associated with artemisinin partner drug (piperaquine) resistance (<i>pfcrt</i> C350R) and limited co-occurence of <i>pfcrt</i> C350R with duplications of <i>plasmepsin 2/3</i>, an epistatic interaction associated with piperaquine resistance. …”

Immediate Outcomes of Aortic Valve Neocuspidization with Glutaraldehyde-treated Autologous Pericardium: a Multicenter Study by Vagram Arutyunyan (10392101)

A Prospective Population Study of Resting Heart Rate and Peak Oxygen Uptake (the HUNT Study, Norway) by Javaid Nauman (134772)

“…Men and women with baseline RHR greater than 80 bpm had 4.6 mL·kg⁻¹·min⁻¹ (95% confidence interval [CI], 2.8 to 6.3) and 1.4 mL·kg⁻¹·min⁻¹ (95% CI, −0.4 to 3.1) lower VO_2peak at follow-up compared with men and women with RHR below 60 bpm at baseline. We found a linear association of change in RHR with VO_2peak (p = 0.03), suggesting that a decrease in RHR over time is likely to be beneficial for cardiovascular fitness. …”

Observation of Coherent Spin Waves in a Three-Dimensional Artificial Spin Ice Structure - data by S Sahoo (10264712)

“…A continuous wave of monochromatic laser light (wavelength λ = 532 nm, power = 60 mW) was focused on the sample to a spot size of around 40 µm, which is close to the lateral dimensions of the sample. …”

Two-Dimensional Tin-Based Chiral Perovskites with a High Degree of Circularly Polarized Luminescence by Peng Wang (34436)

“…The DOCP decreases with increasing temperature and maintains a constant value with the excitation power. …”

Epigenetic Changes Modulate Schistosome Egg Formation and Are a Novel Target for Reducing Transmission of Schistosomiasis by Vitor Coutinho Carneiro (154430)

“…Egg production is required for the transmission and immunopathology of schistosomiasis and females of <i>S. mansoni</i> lay 300 eggs daily. A large fraction of the total mRNA in the mature female worm encodes one eggshell protein, Smp14. …”

DataSheet1_Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia.pdf by Heather A. Ogana (11774297)

“…Therefore, we evaluated four compounds (827171, 827032, 826941, and 825226), previously generated from a large Artemis targeted drug screen. A biochemical assay using a purified Artemis:DNA-PKcs complex shows that the Artemis inhibitors 827171, 827032, 826941, 825226 have nanomolar IC50 values for Artemis inhibition. …”

Two-Dimensional Tin-Based Chiral Perovskites with a High Degree of Circularly Polarized Luminescence by Peng Wang (34436)

“…The DOCP decreases with increasing temperature and maintains a constant value with the excitation power. …”

STarFish: A Stacked Ensemble Target Fishing Approach and its Application to Natural Products by Nicholas T. Cockroft (7540847)

“…Target fishing is the process of identifying the protein target of a bioactive small molecule. To do so experimentally requires a significant investment of time and resources, which can be expedited with a reliable computational target fishing model. …”

Table2_DNA oxidation after exercise: a systematic review and meta-analysis.docx by Mengxin Ye (17306521)

“…In contrast, for untrained participants, a large effect of decreasing circulating 8-OHdG levels was observed, mostly after long-duration aerobic exercise (SMD = −1.16; p < 0.05). …”

Table_1_Reducing delay to endovascular reperfusion after relocating a thrombolysis unit.DOCX by Nicolaj Grønbæk Laugesen (13848019)

“…</p>Results<p>No significant change in ambulance-imaging was observed from a median of 27 min (interquartile range [IQR] 22–37) in period 1 to 30 min (IQR 23–40) in period 2, p = 0.19, while the median time of imaging-reperfusion decreased from 173 min (IQR 137–230) to 114 min (IQR 84–152), p < 0.001. …”

Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA by David G. Hendrickson (257868)

“…For ∼600 mRNAs specifically recruited to Argonaute proteins by miR-124, we found reductions in both the mRNA abundance and inferred translation rate spanning a large dynamic range. The changes in mRNA levels of these miR-124 targets were larger than the changes in translation, with average decreases of 35% and 12%, respectively. …”

Upper Limb Outcome Measures Used in Stroke Rehabilitation Studies: A Systematic Literature Review by Leire Santisteban (2735038)

“…</p><p>Conclusions</p><p>The results showed a large diversity of outcome measures used across studies. …”

Table3_DNA oxidation after exercise: a systematic review and meta-analysis.docx by Mengxin Ye (17306521)

“…In contrast, for untrained participants, a large effect of decreasing circulating 8-OHdG levels was observed, mostly after long-duration aerobic exercise (SMD = −1.16; p < 0.05). …”

DataSheet1_Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia.docx by Heather A. Ogana (11774297)

“…Therefore, we evaluated four compounds (827171, 827032, 826941, and 825226), previously generated from a large Artemis targeted drug screen. A biochemical assay using a purified Artemis:DNA-PKcs complex shows that the Artemis inhibitors 827171, 827032, 826941, 825226 have nanomolar IC50 values for Artemis inhibition. …”

Table1_DNA oxidation after exercise: a systematic review and meta-analysis.docx by Mengxin Ye (17306521)

“…In contrast, for untrained participants, a large effect of decreasing circulating 8-OHdG levels was observed, mostly after long-duration aerobic exercise (SMD = −1.16; p < 0.05). …”