Image1_Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia.jpg by Heather A. Ogana (11774297)

“…Therefore, we evaluated four compounds (827171, 827032, 826941, and 825226), previously generated from a large Artemis targeted drug screen. A biochemical assay using a purified Artemis:DNA-PKcs complex shows that the Artemis inhibitors 827171, 827032, 826941, 825226 have nanomolar IC50 values for Artemis inhibition. …”

Image2_Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia.jpeg by Heather A. Ogana (11774297)

“…Therefore, we evaluated four compounds (827171, 827032, 826941, and 825226), previously generated from a large Artemis targeted drug screen. A biochemical assay using a purified Artemis:DNA-PKcs complex shows that the Artemis inhibitors 827171, 827032, 826941, 825226 have nanomolar IC50 values for Artemis inhibition. …”

Estimated summary statistics of EQ-5D-5L measures over time using a generalized additive mixed model. by Somayeh Momenyan (10111603)

Proportion of large and small EEFs over time in the different culture conditions and for each biological replicate. by Erica M. Pasini (3146643)

“…Drug-treated <i>P. cynomolgi</i> biological replicates on day 9 show a continued decrease in EEFs. The enrichment in hypnozoites (small EEF) peaks at day 11. …”

Frontal cortex tracks surprise separately for different sensory modalities but engages a common inhibitory control mechanism by Jan R. Wessel (7053548)

“…Surprise can occur for any sensory domain, but it is not clear how these separate surprise signals are integrated to affect motor output. By applying a trial-to-trial Bayesian surprise model to human electroencephalography data recorded during a cross-modal oddball task, we tested whether there are separate predictive models for different sensory modalities (visual, auditory), or whether expectations are integrated across modalities such that surprise in one modality decreases surprise for a subsequent unexpected event in the other modality. …”

The raw quantities of 90-day opioid refills and the 90-day refills as a percentage of total annual prescriptions. by Nathan Coppersmith (18764685)

Exhaled metabolic markers and relevant dysregulated pathways of lung cancer: a pilot study by Yingchang Zou (12217753)

“…As a result, the mortality of lung cancer may be decreased in future.Key messages</p><p>In the present study, 11 pathways involving 8 potential biomarkers were discovered to be dysregulated pathways of lung cancer.…”

<i>lov</i> plays a role in EP growth in multiple larval tissues. by Fanli Zhou (3142398)

“…<p>A. <i>lov</i> RNAi knockdown in larval salivary glands. …”

Experimental speed change detection paradigm and example PSTHs. by Udo A. Ernst (11690163)

“…Following a pseudo-randomized delay of 0.66 to 5.5 s, the RF-stimulus rapidly increased (top row) or decreased speed (bottom row). …”

VGF C-terminus peptide changes in human. by Carla Brancia (639524)

“…<p>In plasma (A), ALS patients reveal a reduction in the VGF C-terminus peptide levels seen in the late stage (n = 18) compared to the controls (n = 45) and patients at the early stage (n = 23) (mean ± SEM; percentage of decrease: 16%, p<0.04). …”

Data_Sheet_1_Pharmacokinetics of immunosuppressive agents during hemoperfusion in a sheep model.DOCX by Bettina Leber (819445)

“…For all other substances, a saturable adsorption sub-model with linear decrease of the adsorption effect over the adsorbed amount best described the measured concentrations. …”

Improved Mass Spectrometry Assay For Plasma Hepcidin: Detection and Characterization of a Novel Hepcidin Isoform by Coby M. M. Laarakkers (228091)

“…During prolonged storage of plasma at room temperature, we observed that a decrease in plasma hepcidin-25 was paralleled by an increase in the levels of the hepcidin-24, -22 and -20 isoforms. …”

Visual an­alogue scale (VAS) score changes for bladder pain in all the patients (A; average decrease of VAS score 0.42, 95% CI 0.07 to 0.76, p = 0.02) and subgroup analyses in patients with either interstitial cystitis (IC) or detrusor overactivity (DO) (B; average decrease of VAS score for IC 0.35, 95% CI 0 to 0.7, p = 0.05; average decrease of VAS score for DO 1.4, 95% CI 0.03 to 2.77, p = 0.05). by Changcheng Guo (500326)

“…<p>Visual an­alogue scale (VAS) score changes for bladder pain in all the patients (A; average decrease of VAS score 0.42, 95% CI 0.07 to 0.76, p = 0.02) and subgroup analyses in patients with either interstitial cystitis (IC) or detrusor overactivity (DO) (B; average decrease of VAS score for IC 0.35, 95% CI 0 to 0.7, p = 0.05; average decrease of VAS score for DO 1.4, 95% CI 0.03 to 2.77, p = 0.05).…”

Adverse events n (%). by Qing-Yi Zeng (766224)

“…<p>^a Total events: total patients with at least one adverse event;</p><p>^b Other neuropsychiatric symptoms included language disorders, ataxia, hearing decrease, impairments of calculation and irritability;</p><p>^c Other skin symptoms included hypohidrosis and decrustation;</p><p>^d Gastrointestinal reactions included vomiting, nausea, and abdominal discomfort;</p><p>^e Cytopenia included leucopoenia, oligocythemia, and thrombocytopenia;</p><p>^f Other events included fever, lower limbs edema, tinnitus, renal dysfunction, palpitation, ostealgia/arthralgia, hyperdacryosis, upper respiratory infection, oral ulcer, chest stufly and bitter taste.…”

Total serum immunoglobulin (Ig)-E, IgG1 and IgG2a. Blood was collected 1, 4, 8 and 24 hours, and 4, 8 and 15 days after AP challenge. by Marta Ollé-Monge (642569)

Summary statistics of morphological traits and number of mature eggs in female <i>Oecanthus nigricornis</i> reared in the lab as well as those from a wild population that survived... by Kyla Ercit (645474)

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet by Soonho Kwon (1402972)

“…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …”

(a) Associations Between mAge Acceleration and Visual Attention to the Eyes. by Keiko Ochiai (21453423)

Validation of punch with timestamp: (a) Jab (b) Hook (c) Uppercut. by Saravanan Manoharan (21273304)