Causal associations between kidney function and aortic valve stenosis: a bidirectional Mendelian randomization analysis by Wanqian Pan (18147420)

“…</p> <p>Genetically predicted decreased eGFR may be associated with a raised risk of AVS (OR = 0.045, <i>p</i> = 1.317e-04 by IVW; OR = 0.002, <i>p</i> = 0.004 by MR-Egger, OR = 0.091, <i>p</i> = 0.057 by WM). …”

3a6 cell line response to different substances capable of depleting the levels of mitochondrial DNA. by Mercedes Fernández-Moreno (659000)

“…The analysis of mtDNA copy numbers reflect that treatment with the highest concentration (0.5 mM) for 144 hours decreased the levels of mtDNA in treated cells nearly 98% compared to those of untreated cells. 8x10⁴ cells were plated in each experiment for treatment with a reagent. …”

Image 2_Targeting CCRL2 enhances therapeutic outcomes in a tuberculosis mouse model.tif by Tianyin Wang (10272824)

“…C-C motif chemokine-like receptor 2 (CCRL2) is a unique seven-transmembrane domain receptor that is upregulated by inflammatory signals and mediates leucocyte migration. …”

In vitro fermentation characteristics of ruminant diets using ethanol extract of brown propolis as a nutritional additive by Maria de Fátima Falcão Gomes (12802294)

“…Dry matter degradability of diet decreased exponentially as a function of the increase in dose (y = 678.55×dose–0.271). …”

Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme by JohnCarlo Kristofich (5687573)

“…A previously identified point mutation increases the enzyme’s ability to catalyze the newly needed reaction (required for arginine biosynthesis) but decreases its ability to catalyze its native reaction (required for proline biosynthesis). …”

DataSheet_1_A Strigolactone Signal Inhibits Secondary Lateral Root Development in Rice.pdf by Huwei Sun (4541788)

“…The effects of exogenous GR24 (a synthetic SL analogue), 1-naphthylacetic acid (NAA; an exogenous auxin), 1-naphthylphthalamic acid (NPA; a polar auxin transport inhibitor), and abamine (a synthetic SL inhibitor) on rice secondary LR development were investigated. …”

Subspecialized radiology reporting: productivity and impact on the turnaround times for radiology reports in a middle-income country by Nupur Verma (664047)

“…Data were collected over two 24-month periods (2015-2016 for general reporting and 2017-2018 for subspecialized reporting). Results: A total of 208,516 reports were generated. The median report TAT decreased from 49.1 h and 52.9 h in 2015 and 2016, respectively, to 16.1 h and 15.2 h in 2017 and 2018, respectively (p < 0.001). …”

Organotypic Brain Slice Cultures of Adult Transgenic P301S Mice—A Model for Tauopathy Studies by Agneta Mewes (136833)

“…Neonatal slices displayed a constant high vitality level, while the vitality of adult slice cultures decreased significantly upon cultivation. …”

DataSheet_2_Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization.zip by Dongze Liu (12993036)

“…MR-Egger (ME), inverse variance weighting (IVW), and weighted median (WM) were applied to conduct the MR study and IVW was taken as the main criterion.</p>Results<p>From a genetic perspective, the increase of interferon-inducible protein-10 (IP-10) level significantly increased the risk of ED (P=0.043, odds ratio (OR)=1.269, 95% confidence interval (95%CI): 1.007-1.600), while the increase of interleukin-1 receptor antagonist (IL-1RA) markedly decreased the risk of ED (P=0.037, OR=0.768, 95%CI: 0.600-0.984). …”

Fimasartan reduces clinic and home pulse pressure in elderly hypertensive patients: A K-MetS study by Eun Joo Cho (6569522)

“…However, pulse pressure, a better predictor of cardiovascular events in the elderly, decreased more in elderly than in nonelderly patients by -8.2 ± 0.3 in elderly and -7.0 ± 0.2 mmHg (p<0.0001), respectively, after adjustment for confounding factors. …”

Data_Sheet_1_The APSES Gene MrStuA Regulates Sporulation in Metarhizium robertsii.DOC by Wenjing Yang (466552)

“…In addition, transcription levels of two central regulators of asexual development, AbaA and WetA, were significantly reduced in the mutant; furthermore, the transcription levels of other sporulation related genes, such as Mpk, Phi, Med, Aco, Flu, and FlbD, also decreased significantly. …”

Table_2_A Multilevel Assessment of Plasticity in Response to High-Altitude Environment for Agama Lizards.pdf by Yin Qi (314969)

“…Both lizards were capable of acclimating to the high-altitude environment without sacrificing their performance in bite force, but they also showed high plasticity in tail display behavior by either decreasing the intensity of a specific display component (P. forsythii) or by the trade-off between display components (P. axillaris). …”

Image_4_Schlafen family is a prognostic biomarker and corresponds with immune infiltration in gastric cancer.tif by Jiannan Xu (12282551)

“…We isolated three samples of peripheral blood mononuclear cell (PBMC) and activated T cells; the results showed the expression of SLFN family members decreased significantly when T cell active. In conclusion, the SLFN family of proteins may act as a prognostic indicator of GC and is associated with immune cell infiltration and immune checkpoint expression in GC. …”

Video_1_Focal Cortical Resection and Hippocampectomy in a Cat With Drug-Resistant Structural Epilepsy.MOV by Daisuke Hasegawa (239088)

“…<p>Epilepsy surgery is a common therapeutic option in humans with drug-resistant epilepsy. …”

Image_4_A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.tif by Jinglei Xiao (1422004)

“…Mathematical simulation indicated that a left shift of Na_V activation produced a Hopf bifurcation, leading to cell oscillations. …”

Persistence of isolate 101 in the oral mucosa is associated with a reduced virulence profile and an altered metabolic signature. by Christina Lemberg (5490911)

“…<p><b>A.</b> PCA plot generated from the 5589 <i>C</i>. …”

Image_1_The burden of poisoning in children hospitalised at a tertiary-level hospital in South Africa.JPEG by Mahtaab Khan (17257735)

“…Introduction<p>Globally, childhood poisoning, accounts for a significant proportion of emergency department admissions. …”

Table 1_How long do pathogens persist and survive in water? A systematic review.docx by Famous K. Sosah (22509419)

“…</p>Methods<p>A systematic search of PubMed, Web of Science, Google Scholar, and Scopus databases was conducted to identify studies published from January 1, 1990, to July 17, 2024. …”

MxA mRNA Quantification and Disability Progression in Interferon Beta-Treated Multiple Sclerosis Patients by Federico Serana (173338)

“…At the group level, none of these biological features correlated with the measures of clinical disease activity or progression. However, when MxA mRNA was evaluated not at the single time point as a dichotomic marker (induced vs. non-induced), but as the mean of its values measured over the 6-to-24 month period, the increasing average MxA predicted a decreasing risk of short-term disability progression, independently from the presence of relapses. …”

Pleiotropic Benefit of Monomeric and Oligomeric Flavanols on Vascular Health - A Randomized Controlled Clinical Pilot Study by Antje R. Weseler (192942)

“…<div><h3>Background</h3><p>Cardiovascular diseases are expanding to a major social-economic burden in the Western World and undermine man's deep desire for healthy ageing. …”