Image_1_Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification.JPEG by Muge Qile (6917804)

“…<p>K_IR2.1 potassium channels, producing inward rectifier potassium current (I_K1), are important for final action potential repolarization and a stable resting membrane potential in excitable cells like cardiomyocytes. …”

Image_2_Hsa_circ_0000479 as a Novel Diagnostic Biomarker of Systemic Lupus Erythematosus.TIF by Gangqiang Guo (3278922)

“…Western blotting revealed that the expression of Wnt-16 protein was significantly decreased in SLE.</p><p>Conclusion: Our results suggest that hsa_circ_0000479 has potential as a novel biomarker for the diagnosis of SLE.…”

A CFD- RSM study of cuttings transport in non-Newtonian drilling fluids: Impact of operational parameters by Awad A.M.

“…As the drill pipe rotational speed increased, the pressure drop decreased slightly until a critical rotatory speed was reached, thereafter, the pressure drop increased markedly. …”
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<i>GADD45a</i> promoter activity and functional promoter region in response to mechanical stress. by Sumegha Mitra (579813)

“…Comparatively, 18% CS-induced luciferase activity was significantly decreased in 0.8 kb, 0.4 kb and 0.2 kb fragments. (<b>D</b>) <i>In silico</i> analysis of <i>GADD45a</i> promoter region −371 to −133 by Genomatix predicted binding sites for transcription factor SP1. …”

Post-hospital mortality in children aged 2-12 years in Tanzania: A prospective cohort study by Duncan K. Hau (5628965)

“…Factors associated with mortality were determined using Cox regression analysis.</p><p>Results</p><p>A total of 506 participants were enrolled. In-hospital mortality rate was 7.7% (39/506). …”

Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population by Xiaomu Kong (447734)

Image1_Ocular pharmacological and biochemical profiles of 6-thioguanine: a drug repurposing study.pdf by Maria Consiglia Trotta (6243830)

“…Introduction:<p>The purine analog 6-thioguanine (6TG), an old drug approved in the 60s to treat acute myeloid leukemia (AML), was tested in the diabetic retinopathy (DR) experimental in vivo setting along with a molecular modeling approach.</p>Methods:<p>A computational analysis was performed to investigate the interaction of 6TG with MC1R and MC5R. …”

Robotic Right Lower Lobe Anteromedial Basilar (S7 + S8) Segmentectomy: A Case Report and Discussion by Ankit Dhamija (7901640)

“…This is especially evident in patients with emphysema and obesity. The authors provide a video and description of a patient with a nodule isolated to S7+S8 of the right lower lobe.…”

Long-term health status and trajectories of seriously injured patients: A population-based longitudinal study by Belinda J. Gabbe (193450)

“…</p><p>Methods and findings</p><p>A population-based, prospective cohort study using the Victorian State Trauma Registry (VSTR) was undertaken. …”

ChIP Reveals That RPA Is a Limiting Factor in <i>dmc1Δ</i> Cells by Rebecca Johnson (77303)

“…The difference in ChIP efficiencies for wild-type and <i>dmc1</i>Δ cells is greatest for the site far from VDE-DSB1, implying that as resection proceeds it becomes more difficult to compete for Rfa1, which may be stably bound to ssDNA created earlier, close to DSB sites.</p><p>(A) Close to a Spo11-DSB hotspot, the ChIP enrichment decreases with repair in wild-type cells but not in <i>dmc1</i>Δ cells.…”

Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study by Dylan D. Thomas (8173575)

“…<div><p>Objective</p><p>Medium chain triglycerides (MCT) have unique metabolic properties which may improve insulin sensitivity (Si) and beta cell function but data in humans are limited. We conducted a 6-week clinical trial of MCT oil supplementation.…”

Data_Sheet_1_A New Predictive Model for the Prognosis of MDA5+ DM-ILD.PDF by Qian Niu (425660)

“…Poor prognosis was found more frequently in patients who were older, clinically amyopathic variant of dermatomyositis (CADM), and/or with short duration, short interval of DM and ILD, long length of stay, fever, dyspnea, non-arthralgia, pulmonary infection, pleural effusion (PE), high total computed tomography scores (TCTs), ground-glass opacity (GGO), consolidation score, reticular score and fibrosis score, decreased forced vital capacity (FVC), forced expiratory volume in 1s (FEV1), albumin, A/G, glomerular filtration rate (GFR) and tumor necrosis factor α (TNFα), high titer of anti-MDA5, proteinuria, high levels of monocyte, lactate dehydrogenase (LDH), ferritin (FER), neuron specific enolase (NSE) and glucocorticoid, antibiotic, antiviral, and non-invasive positive pressure ventilation (NPPV). …”

Efficacy and Safety of Anti-Interleukin-5 Therapy in Patients with Asthma: A Systematic Review and Meta-Analysis by Fa-Ping Wang (3358667)

Cryo-EM structures of Map1 bound to ribosomes via expansion segment ES27a. by Alexandra G. Knorr (15333351)

“…<p>(<b>A</b>) Concentrated eluate obtained from Map1-TAP affinity purification shown on a 12% Nu-PAGE. …”

Treatment with a fecal microbiota transplant following spinal cord injury reduced anxiety-like behaviour. by Emma K. A. Schmidt (8307642)

“…<p>Animals were tested in the elevated plus maze 3 weeks following surgeries. <b>(A)</b> Representative images from the motion tracking software used to analyze the elevated plus maze. …”

PRMT5 stabilizes vCyclin protein expression in a manner dependent on its methyltransferase activity. by Danping Niu (10912688)

“…<p>(A-B) Effect of PRMT5 on vCyclin expression. First, HEK293T cells were cotransfected with fixed amounts of vCyclin expression plasmid and increasing amounts of PRMT5 expression plasmids. …”

Why Do People Migrate Irregularly? Evidence From a Lab-in-the-Field Experiment in West Africa by Tijan Bah (18888085)

“…In this context, our experimental results show that providing potential migrants with official numbers on the probability of getting a legal residence permit decreases their likelihood of migration by 2.88 percentage points (pp), while information on the death risk of migrating increases their likelihood of migration by 2.29 pp—although the official numbers should be regarded as a lower bound to actual mortality. …”

Ccr7 inhibits β-catenin activity via a Gsk3β-indepenedent mechanism. by Shu-Yu Wu (129447)

“…Compared to control (a, d), <i>ccr7</i> RNA overexpressing blastulae showed strongly decreased (b, e), while MO1-<i>ccr7</i> injected blastulae showed increased, ΔNβ-catenin-GFP signal (c, f). …”

CNNM4 but not SLC41A1 stimulates TRPM7-mediated divalent cation entry. by Zhiyong Bai (259036)

“…<i>n</i> = 100.* indicates a <i>p</i>-value of less than 0.05. <b>(C)</b> Separate control experiments were performed using the Mag-Fura-2 dye to show that the magnesium levels of 293-TRPM7 cells expressing CNNM4 as well as SLC41A1 decreased compared to 293-TRPM7 cells alone. …”

Bistable pattern formation by JNK/AP-1 and JAK/STAT signaling by a mutual repression motif. by Janhvi Jaiswal (14266407)

“…<b>(C)</b> The steady-state patterns are classified as “simple” bistable when JAK/STAT decreases and JNK/AP-1 increases in space with a relative change greater than 10% (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001665#sec011" target="_blank">Materials and methods</a> for details). …”