Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model by Da’as, Sahar Isa

“…To investigate the c-MYBPC3 HCM-related cardiac impairment, we generated a zebrafish mypbc3-knockout model. These knockout zebrafish displayed significant morphological heart alterations related to a significant decrease in ventricular and atrial diameters at systolic and diastolic states at the larval stages. …”
Get full text
Get full text
Get full text

DataSheet1_Heavy users fail to fall into filter bubbles: evidence from a Chinese online video platform.pdf by Chenbo Fu (19537921)

“…The filter bubble, conceived as a negative consequence of algorithm bias, means the reduction of the diversity of users’ information consumption, garnering extensive attention. …”

Effect of Pay-For-Outcomes and Encouraging New Providers on National Health Service Smoking Cessation Services in England: A Cluster Controlled Study by Hugh McLeod (724368)

“…</p><p>Results</p><p>The number of four-week quits per 1,000 adult population increased per year on average by 9.6% in the intervention PCTs compared to a decrease of 1.1% in the control PCTs (incident rate ratio 1∙108, p<0∙001, 95% CI 1∙059 to 1∙160). …”

Presentation1_The effects and safety of anticoagulation or antiplatelet therapy following TIPS in cirrhotic patients with portal hypertension: A meta-analysis.pdf by Xiaotong Xu (619837)

“…The use of anticoagulation or antiplatelet therapy may result in a significant decrease in the incidence of new portal vein thrombosis and mortality over 1 year.…”

Table_4_A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats.DOCX by Valérie Daugé (9632357)

“…Fischer rats treated with the probiotic mixture manifested a decrease in anxiety-like behaviors, in the immobility time in the forced swimming test, as well as in levels of dopamine and its major metabolites, and those of serotonin metabolites in the hippocampus and striatum. …”

Table_5_Effect of BAFF blockade on the B cell receptor repertoire and transcriptome in a mouse model of systemic lupus erythematosus.xlsx by Tao Huang (110613)

“…Introduction<p>Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Anti-B-cell-activating factor (BAFF) therapy effectively depletes B cells and reduces SLE disease activity. …”

Data_Sheet_1_Neuron-Glia Crosstalk Plays a Major Role in the Neurotoxic Effects of Ketamine via Extracellular Vesicles.docx by Donald H. Penning (11439733)

“…These results contribute to a better understanding of ketamine neurotoxic effects in humans and to the development of potential approaches to decrease its neurodevelopmental impact.…”

Table_3_A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats.DOCX by Valérie Daugé (9632357)

“…Fischer rats treated with the probiotic mixture manifested a decrease in anxiety-like behaviors, in the immobility time in the forced swimming test, as well as in levels of dopamine and its major metabolites, and those of serotonin metabolites in the hippocampus and striatum. …”

Table3_Japanese quails (Cortunix Japonica) show keel bone damage during the laying period—a radiography study.XLSX by Lisa Hildebrand (11169687)

“…Furthermore, there was a decrease in radiographic density, lateral surface area, and length of the keel bone between weeks of age 8 and 19. …”

Data_Sheet_1_A Developmental Profile of Children With Autism Spectrum Disorder in China Using the Griffiths Mental Development Scales.zip by Hong-Hua Li (6445244)

“…The locomotor quotient decreased in line with age at diagnosis, while autism severity and age had significant effects on the general and subscale quotients and sex had a significant effect on performance quotient. …”

Table_1_Preventive effect of cranberries with high dose of proanthocyanidins on urinary tract infections: a meta-analysis and systematic review.DOCX by Zheyu Xiong (20353206)

“…</p>Discussion<p>These findings showed a strong correlation between the daily use of the active ingredient PACs found in cranberry products and the prevention of UTIs. …”

PKC signaling and calcineurin independently regulate tolerance to ergosterol biosynthesis inhibitors via a common target in <i>C. albicans</i>. by Shantelle L. LaFayette (243114)

“…(<b>B</b>) Simultaneous inhibition of calcineurin and Pkc1 signaling does not synergistically decrease FL tolerance of a WT strain (SN95). A fractional inhibitory concentration (FIC) assay was carried out in YPD medium containing a fixed concentration of 0.5 µg/mL FL and gradients of the calcineurin inhibitor cyclosporin A (CsA) and the PKC inhibitor staurosporine (STS). …”

DataSheet_1_A multiproxy approach to reconstruct the Late Holocene environmental dynamics of the semiarid Andes of central Chile (29°S).pdf by Alejandra Martel-Cea (12397837)

“…Between 2400 and 1400 cal yrs BP, wetter than present conditions occurred based on the intense weathering of the lake basin and the dominance of upper Andean vegetation. A decrease in moisture along with sub-centennial discrete wet pulses and lake-level changes occurred until ~800 cal yrs BP followed long-term stable climate conditions between 1850 and 1950 AD as suggested by a drop in vegetation productivity and low lake levels. …”

Table_1_Surgical quadriceps lengthening can reduce quadriceps spasticity in chronic stroke patients. A case-control study.DOCX by Andrea Merlo (4520980)

“…</p>Conclusions<p>Functional surgery inclusive of QF aponeurectomy can be effective in reducing or suppressing spasticity in chronic stroke patients. This is possibly a result of the reduction in neuromuscular spindle activation due to a decrease in muscle shortening, passive tension, and stiffness.…”

DataSheet_1_Interindividual differences contribute to variation in microbiota composition more than hormonal status: A prospective study.xlsx by Zuzana Jackova (14311780)

“…</p>Results<p>We found no significant changes in gut microbiota composition 6 months after oophorectomy, despite major changes in hormone levels, BMD, and bone metabolism. A small decrease in bacterial diversity was apparent 18 months after surgery in taxonomy-aware metrics. …”

Image_1_Dietary patterns and diabetes mellitus among people living with and without HIV: a cross-sectional study in Tanzania.JPEG by Evangelista Malindisa (15340190)

“…Higher adherence to VRP was associated with a borderline decrease in diabetes. No association was observed between VPP with either prediabetes or diabetes.…”

Table 1_Protocol for a randomized controlled trial of patient–portal–based screening for substance use among people with HIV.docx by Eric Roessler (12009279)

“…Background<p>Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life with HIV and Substance Use (ePORTAL HIV-S) is a research project funded by the National Institute for Drug Abuse to implement and evaluate multi-level interventions to decrease barriers to substance use screening and treatment for PLWH. …”

Data_Sheet_1_Effectiveness and Safety of Rituximab for Refractory Myasthenia Gravis: A Systematic Review and Single-Arm Meta-Analysis.docx by Cong Zhao (306050)

“…Nearly 10–30% of patients with MG are refractory to conventional therapy. Rituximab (RTX), a monoclonal antibody targeting CD20, is increasingly used in autoimmune disorders. …”

Table_2_Dietary patterns and diabetes mellitus among people living with and without HIV: a cross-sectional study in Tanzania.DOCX by Evangelista Malindisa (15340190)

“…Higher adherence to VRP was associated with a borderline decrease in diabetes. No association was observed between VPP with either prediabetes or diabetes.…”

Table_2_Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis.DOCX by Menghao Teng (16939097)

“…Reverse MR analyses indicated that cataract may lead to a decrease in vascular endothelial growth factor (VEGF) levels (OR: 3.326 × 10⁻⁰⁴, 95% CI: 5.198 × 10⁻⁰⁷ − 2.129 × 10⁻⁰¹, p = 0.0151).…”