Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies by Bernard Barlaam (1638841)

“…Short-term treatment with compound <b>24</b> led to a rapid dose- and time-dependent decrease of pSer2-RNAP2 and Mcl-1, resulting in cell apoptosis in multiple hematological cancer cell lines. …”

Structural, Magnetic, and Gas Adsorption Study of a Series of Partially Fluorinated Metal−Organic Frameworks (H<i>F</i>-MOFs) by Pradip Pachfule (1875616)

“…Thermal gravimetric analysis performed on as-synthesized H<i>F</i>-MOFs revealed that these compounds have high thermal stability (∼350 °C). The continuous decrease of the χ<i>T</i> product with decreasing <i>T</i> for Co-H<i>F</i>MOF-D and Co-H<i>F</i>MOF-W respectively indicates the presence of antiferromagnetic exchange interaction between two Co²⁺ (<i>S</i> = 3/2) metal centers within a cluster.…”

The heterotopic heart transplantation in mice as a small animal model to study mechanical unloading – Establishment of the procedure, perioperative management and postoperative sco... by Sumi Westhofen (4768563)

“…<div><p>Background</p><p>Unloading of failing hearts by left ventricular assist devices induces an extensive cardiac remodeling which may lead to a reversal of the initial phenotype–or to its deterioration. …”

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Signalling Exerts Chondrogenesis Promoting and Protecting Effects: Implication of Calcineurin as a Downstream Target by Tamás Juhász (195396)

“…Application of PACAPs failed to rescue cartilage formation when the activity of calcineurin was pharmacologically inhibited with cyclosporine A. Moreover, exogenous PACAPs prevented diminishing of cartilage formation and decrease of calcineurin activity during oxidative stress. …”

Data_Sheet_1_Bridge to health informatics—a 5-week intensive online program to increase diversity in health informatics.xlsx by Angelita P. Howard (16936107)

DataSheet1_Kinetics of endothelin-1 and effect selective ETA antagonism on ETB activation: a mathematical modeling analysis.docx by K. Melissa Hallow (9248960)

“…The drug concentration required to cause a decrease in [ET1-ET_B] was lower as ET_A selectivity decreased.…”

Data_Sheet_4_Association between dietary antioxidant quality score and severity of coronavirus infection: a case–control study.PDF by Mobina Aghajani (16499340)

“…Our outcomes (after multivariate adjustment) suggested that higher adherence to DAQS was significantly associated with a decreased risk of COVID-19 infection severity (OR = 0.12; 95% CI: 0.04–0.29, p < 0.001). …”

Image_2_Trace Metal Dynamics in a Tropical Mangrove Tidal Creek: Influence of Porewater Seepage (Can Gio, Vietnam).jpg by Nguyen Thanh-Nho (9259460)

“…Previous studies demonstrated a decrease of trace metal stocks in mangrove soils seaward, possibly due to the export of dissolved metals through tidal pumping. …”

DataSheet3_Association of neutropenia at disease onset with severe surgical necrotizing enterocolitis and higher mortality: A retrospective study.pdf by Fanyue Qin (13935300)

“…A decrease in ANC at the onset of NEC was associated with an increased probability of severe surgical NEC (crude odds ratio [OR] 1.248, 95% CI 1.107–1.407; P = 0.000). …”

<i>Ixodes ricinus</i> and Its Endosymbiont <i>Midichloria mitochondrii</i>: A Comparative Proteomic Analysis of Salivary Glands and Ovaries by Monica Di Venere (799152)

“…We detected 21 spots showing significant differences in the relative abundance between the OT and SG, ten of which showed 4- to 18-fold increase/decrease in density. This work allowed to establish a method to characterize the proteome of <i>I</i>. …”

Effect of salinity stress in Setaria viridis (L.) P. Beauv. accession A10.1 during seed germination and plant development by Thalita Massaro Malheiros Ferreira (10379276)

“…Plant in the vegetative growth stage experienced a reduction in the evapotranspiration rates and pigment levels, along with an impairment in the system of capture and use of light, and a decrease in the leaf gas exchange rates, resulting in less accumulation of dry and fresh plant biomass proportional to the salt dose used. …”

DataSheet1_Causal relationship between Women’s reproductive traits and postpartum depression: a multivariate mendelian randomization analysis.PDF by Zhen Kang (335450)

“…In the MVMR result, only AFB (OR = 0.804, 95% CI 0.661–0.978; p = 0.029) retained a direct causative relationship with PPD.</p>Conclusion<p>The study indicates that AFB is a significant risk factor for PPD. …”

DataSheet_1_A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation.pdf by Massimo R. Mannarino (12244579)

“…</p>Results<p>Repeated low doses of LPS caused a decrease in circulating EPCs and l-kyn supplementation, mimicking IDO1 activation, significantly increased EPC numbers under homeostatic conditions preventing EPC decline in low-grade endotoxemia. …”

Image_7_AtDAT1 Is a Key Enzyme of D-Amino Acid Stimulated Ethylene Production in Arabidopsis thaliana.tif by Juan Suarez (3164730)

“…<p>D-Enantiomers of proteinogenic amino acids (D-AAs) are found ubiquitously, but the knowledge about their metabolism and functions in plants is scarce. A long forgotten phenomenon in this regard is the D-AA-stimulated ethylene production in plants. …”

Table1_Impact of a heart failure multidisciplinary clinic on the reduction of healthcare-related events and costs: the GEstIC study.doc by Rita Rego (17064615)

“…As a result, there was a significant decrease of 12.6 days in the length of hospital stay due to HF per patient (15.6 vs. 3.0, p < 0.001). …”

DataSheet_1_Discovery of a gene cluster for the biosynthesis of novel cyclic peptide compound, KK-1, in Curvularia clavata.docx by Shigenari Yamaguchi (14482392)

“…The genes kk1A, kk1D, kk1H, and kk1I, which showed a significant decrease in KK-1 productivity due to deletion, were presumed to be directly involved in KK-1 structure formation, including the biosynthesis of the constituent residues. kk1C, kk1E, kk1G, and kk1J, which maintained a certain level of KK-1 productivity despite deletion, were possibly involved in promoting or assisting KK-1 production, such as extracellular transportation and the removal of aberrant units incorporated into the peptide chain.…”

Table 2_A scoping review of the feasibility, usability, and efficacy of digital interventions in older adults concerning physical activity and/or exercise.docx by Ethan C. J. Berry (21074345)

“…Digital interventions are generally feasible, usable, and effective for older adults, offering a promising, scalable approach for promoting PA. …”

Table_3_Trends in incidence and mortality of esophageal cancer in China 1990−2019: A joinpoint and age-period-cohort analysis.xlsx by Fajun Li (13247448)

“…The time period showed a trend of first rising and then decreasing, and the RR of time period effect was lower in 2015 than that in 1990 in females regarding both incidence and mortality, whereas males showed a significant upward trend in both incidence and mortality. …”

A risk-model for hospital mortality among patients with severe sepsis or septic shock based on German national administrative claims data by Daniel Schwarzkopf (4984601)

“…<div><p>Background</p><p>Sepsis is a major cause of preventable deaths in hospitals. …”

Highly Stable Polyoxovanadate-Based Zn–MOF with Dual Active Sites as a Solvent-free Catalyst for C–C Bond Formation by Hongrui Tian (6493886)

“…A polyoxovanadate-based zinc–organic framework, [Zn­(bix)]­{V₂O₆}­(V-Zn-MOF, bix = 1,4-bis­(imidazole-1-ylmethyl)­benzene), was successfully synthesized under hydrothermal conditions. …”