Image_2_The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum.TIF by Thabatta Leal Silveira Andrezo Rosa (5489132)

“…During thalidomide administration, the drug of choice for ENL treatment, a decrease in the mRNA and protein levels of some of these genes both in the skin and blood was observed. …”

datasheet1_The Immunomodulatory Potential of Copper and Silver Based Self-Assembled Metal Organic Biohybrids Nanomaterials in Cancer Theranostics.pdf by Neela Prajapati (10038521)

“…Successive treatment of CuHARS to glioma cells also proved to be an effective approach considering the decrease in the total count of cells by 11.84 fold in case of three successive treatments compared to a single dose which only decreased the cell count by 2.45 fold showing the dose-dependent increasing toxicity toward glioma cells. …”

Supplementary file 1_Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice.docx by Teame Gereziher Mehari (11253141)

“…Introduction<p>Gossypol impairs reproduction in both sexes, inducing mitochondrial dysfunction, irregular cycles, and fewer ovarian follicles, leading to decreased fertility rates. The present investigation was undertaken to evaluate the toxicological effects of (+)-gossypol powder, a substance derived from cottonseed in mice.…”

Discovery of Dramatically Improved Ammonia Synthesis Catalysts through Hierarchical High-Throughput Catalyst Screening of the Fe(211) Surface by Jon Fuller (6919253)

“…At 673 K and 20 atm, we find a decrease, δ­(Δ<i>G</i>^∫) = −0.19 eV, in the overall reaction free-energy barrier for the Co-doped case. …”

Macrophage-tropic HIV-1 isolates, which are known to bind human CD4 more tightly, are promiscuous in their use of primate CD4 receptors. by Cody J. Warren (563898)

“…<p>(A, B) Cells stably expressing various primate CD4 receptors (x-axis), along with human CCR5, were infected with Q23ΔEnv-GFP pseudotyped with (A) early HIV-1 Envelopes (Envs) or (B) Envs from common macrophage-tropic HIV-1 isolates. …”

NADH oxidase activities of recombinant gFlHb. by Edar O. Pech-Santiago (13871266)

“…<p>(A) The reaction was performed in 50 mM potassium phosphate buffer by adding 160 μM NADH at time zero, after 0.37 μM gFlHb (blue arrow) was added to reach a stable baseline with negligible spurious reaction. …”

Impact of BCG vaccination on the repertoire of human gamma/delta T cell receptors (ms data) by Mei Xia (14585347)

“…While many of the clonotypes whose frequency changed after BCG were not shared among multiple individuals in the cohort, several shared (i.e., “public”) clonotypes were identified with a consistent increase or decrease in frequency across more than one individual; the degree of sharing of these clonotypes was significantly greater than the minimal sharing that would be expected among gTCR and dTCR repertoires. …”

PLK2i treatment of OHSCs does not affect generation of pS129 positive aggregates, but reduces the nuclear pS129 intensity. by Sara Elfarrash (8159490)

“…Scale bars = 20 μm. b) Quantification of the amount of aggregation (aggregate area normalized to tissue area), defined by MJF-14 staining (p-value = 0.09). c-d) Quantification of the mean fluorescence intensity of α-syn aggregates detected with MJF-14 (c, p-value = 0.712) and aggregate-specific pS129 that overlaps with MJF-14 (d, p-value = 0.214). e) Quantification of nuclear (non-aggregate related) pS129, illustrating a significant decrease in mean fluorescence intensity following PLK2i-treatment (p-value = 0.0087). f) Relative ratio of aggregate-specific pS129/nuclear pS129 in PFF-injected slices shows an increase of ratio of the signals of aggregates/background following PLK2i treatment, due to reduction of the non-aggregate-related nuclear pS129-signal (p-value = 0.009). …”

Genetic ablation of <i>C1ql1</i>-expressing OPCs prevents myelination in the forebrain without affecting axogenesis. by Shayan Moghimyfiroozabad (19066182)

“…Quantification of the thickness of the fiber bundles in the corpus callosum and the intensity of NF in the cortex shows a small decrease in the thickness of the lateral part of the corpus callosum, probably explained by reduced myelination. …”

Table_3_Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis.xlsx by Roel Bijkerk (4662769)

“…In order to identify pericyte long non-coding RNAs (lncRNAs) that could serve as a target to decrease myofibroblast formation and counteract the progression of kidney fibrosis we employed two models of experimental kidney injury, one focused on kidney fibrosis (unilateral ureteral obstruction; UUO), and one focused on acute kidney injury that yields kidney fibrosis in the longer term (unilateral ischemia-reperfusion injury; IRI). …”

Table_7_Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis.DOCX by Roel Bijkerk (4662769)

“…In order to identify pericyte long non-coding RNAs (lncRNAs) that could serve as a target to decrease myofibroblast formation and counteract the progression of kidney fibrosis we employed two models of experimental kidney injury, one focused on kidney fibrosis (unilateral ureteral obstruction; UUO), and one focused on acute kidney injury that yields kidney fibrosis in the longer term (unilateral ischemia-reperfusion injury; IRI). …”

Defective cellular signalling in <i>Cdkl5</i> knockout mice. by Elena Amendola (565348)

“…(<b>C</b>) Western blot quantification revealed a significant decrease in phospho-Akt immunoreactivity protein in mutant <i>Cdkl5</i> mice compared with wild-type controls (female: WT, N = 10, HET, N = 6, KO, N = 10; male: WT, N = 5, KO, N = 6; mean ± SEM) (mean ± SEM; *P<0.05, **P<0.01). …”

DataSheet1_Structural features and antioxidant activities of polysaccharides from different parts of Codonopsis pilosula var. modesta (Nannf.) L. T. Shen.ZIP by Li-Xia Li (6517229)

“…The monosaccharide composition of CLRP-1 was Ara, Rha, Fuc, Xyl, Man, Gal, GlcA, GalA in a ratio of 3.8: 8.4: 1.0: 0.8: 2.4: 7.4: 7.5: 2.0: 66.7, and Ara, Rha, Gal, GalA in a ratio of 5.8: 8.9: 8.0: 77.0 in for CLSP-1. …”

Particle-Size-Dependent Distribution of Carboxylate Adsorption Sites on TiO₂ Nanoparticle Surfaces:  Insights into the Surface Modification of Nanostructured TiO<sub>2</... by Qing-Li Zhang (2706889)

“…Size-dependent surface binding forms of the carboxylic group on the surface of TiO₂ nanoparticles were investigated by a surface-binding transient probe molecule all-<i>trans</i>-retinoic acid (ATRA), where the excited triplet-state probe molecule generated by a photoinduced interfacial charge recombination for the adsorbed monolayer acts as a reporter for the different surface binding forms. …”

Table_2_Microbial Community Redundancy and Resilience Underpins High-Rate Anaerobic Treatment of Dairy-Processing Wastewater at Ambient Temperatures.XLSX by Lara M. Paulo (8567841)

“…For example, the main pH shock led to a drop in the methane content to 15%, COD removals decreased to 0%, while the archaeal population decreased to ~11% both at DNA and cDNA levels. …”

Solvation and Thermalization of Electrons Generated by above-the-Gap (12.4 eV) Two-Photon Ionization of Liquid H₂O and D₂O by Rui Lian (2533948)

“…The “continuous blue shift” and the “temperature jump” models, in which the spectral profile does not change as it progressively shifts, as a whole, to the blue, are not supported by our data. …”

siRNA induces transcription initiation arrest, but not DNA methylation or histone deacetylation, of heparanase promoter. by Guosong Jiang (182435)

“…The symbol (#) indicates a significant decrease from untransfected control (mock) or siScb. …”

Data_Sheet_1_Gene Co-expression Network Reveals Potential New Genes Related to Sugarcane Bagasse Degradation in Trichoderma reesei RUT-30.PDF by Gustavo Pagotto Borin (751443)

“…Our results demonstrate a vast range of new promising targets that merit additional studies to improve the cellulolytic potential of T. reesei strains and to decrease the production costs of 2G ethanol.…”

Particle-Size-Dependent Distribution of Carboxylate Adsorption Sites on TiO₂ Nanoparticle Surfaces:  Insights into the Surface Modification of Nanostructured TiO<sub>2</... by Qing-Li Zhang (2706889)

“…Size-dependent surface binding forms of the carboxylic group on the surface of TiO₂ nanoparticles were investigated by a surface-binding transient probe molecule all-<i>trans</i>-retinoic acid (ATRA), where the excited triplet-state probe molecule generated by a photoinduced interfacial charge recombination for the adsorbed monolayer acts as a reporter for the different surface binding forms. …”

Endothelin-1 Inhibits Prolyl Hydroxylase Domain 2 to Activate Hypoxia-Inducible Factor-1α in Melanoma Cells by Francesca Spinella (247034)

“…<div><h3>Background</h3><p>The endothelin B receptor (ET_BR) promotes tumorigenesis and melanoma progression through activation by endothelin (ET)-1, thus representing a promising therapeutic target. The stability of hypoxia-inducible factor (HIF)-1α is essential for melanomagenesis and progression, and is controlled by site-specific hydroxylation carried out by HIF-prolyl hydroxylase domain (PHD) and subsequent proteosomal degradation.…”