Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Image_1_Addition of Fibroblast-Stromal Cell Markers to Immune Synovium Pathotypes Better Predicts Radiographic Progression at 1 Year in Active Rheumatoid Arthritis.tif by Xue-Pei Zhang (10650773)

“…Objectives<p>This study aims to investigate if addition of fibroblast-stromal cell markers to a classification of synovial pathotypes improves their predictive value on clinical outcomes in rheumatoid arthritis (RA).…”

DataSheet1_Transcriptional time course after rotator cuff repair in 6 month old female rabbits.XLSX by Laura S. Vasquez-Bolanos (11242737)

“…Many were also significantly enriched at 2 weeks, with the addition of NIF/NF-kappaB signaling, transcription in response to hypoxia, and mRNA stability alongside many additional pathways. There was also a shift in transcriptional activity at 4 weeks post-repair with significantly enriched pathways for lipids, hormones, apoptosis, and cytokine activity, despite an overall decrease in the number of differentially expressed genes. …”

Data Sheet 3_Global trends in ambient particulate matter-attributable ischemic heart disease among the elderly (1990–2021).csv by Yangxi Zeng (20710481)

“…Although BAPC projections indicate a continued decline, a potential rise in pollution around 2035 may slow the rate of decrease or temporarily flatten the downward trajectory.…”

DataSheet3_An Herbal Product Alleviates Bleomycin-Induced Pulmonary Fibrosis in Mice via Regulating NF-κB/TNF-α Signaling in Macrophages.xlsx by Fei Jing (298892)

“…Fuzheng Huayu (FZHY) formula, a Chinese herbal product, is effective in treating pulmonary fibrosis in our previous study. …”

Characteristics of residents and shifts. by Yael Appelboom (20570815)

“…Mental effort rose from 17h onwards higher values, whereas a decrease in comfortability was seen from 21h onwards.…”

DataSheet2_An Herbal Product Alleviates Bleomycin-Induced Pulmonary Fibrosis in Mice via Regulating NF-κB/TNF-α Signaling in Macrophages.xlsx by Fei Jing (298892)

“…Fuzheng Huayu (FZHY) formula, a Chinese herbal product, is effective in treating pulmonary fibrosis in our previous study. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Image_1_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS4895”... by Sayantan Sarkar (11975699)

“…A secondary objective was to undertake a genetic marker/quantitative trait locus (QTL) genetic analysis using the AgNO₃ phenotyping results. …”

Table 1_Evaluation of the cardiorespiratory and antinociceptive effects of the total intravenous anesthesia technique with xylazine-butorphanol-propofol compared to isoflurane in c... by Shogo Sato (16544880)

“…Norepinephrine concentrations in both groups demonstrated a significant decrease from baseline values prior to the nociceptive stimuli; however, the difference disappeared during and before the stimulus. …”

DataSheet_1_Evaluation of the immune feature of ACPA-negative rheumatoid arthritis and the clinical value of matrix metalloproteinase-3.docx by Zhaojun Liang (3404633)

“…However, about one-third of RA patients are negative for ACPAs, which presents a challenge to the early diagnosis of RA. The purpose of this study was to analyze differences in lymphocyte subsets and CD4⁺ T cell subsets between ACPA⁺ and ACPA^- RA patients, and to evaluate the value of matrix metalloproteinase-3 (MMP-3) as a diagnostic and monitoring marker in ACA^- RA patients. …”

Study selection flow diagram. by Laurence Weinberg (2960238)

“…Scoping review registered on OSF registries (<a href="https://osf.io/4mg7n" target="_blank">https://osf.io/4mg7n</a>).…”

Data_Sheet_1_Evaluation of safety and efficacy of inhaled ambroxol in hospitalized adult patients with mucopurulent sputum and expectoration difficulty.docx by Zeguang Zheng (474806)

“…</p>Results<p>Between 10 April 2018 and 23 November 2020, 316 patients were recruited and assessed for eligibility, of whom 138 who received inhaled ambroxol and 134 who received a placebo were included. Patients who received inhaled ambroxol had a significantly greater decrease in the sputum property score compared with patients who received inhalation of placebo (difference: −0.29; 95% CI: −0.53 to −0.05; p = 0.0215). …”

Table_1_The Impact of Hippocampal Sex Hormones Receptors in Modulation of Depressive-Like Behavior Following Chronic Anabolic Androgenic Steroids and Exercise Protocols in Rats.XLS... by Dragica Selakovic (4068406)

“…<p>The aim of this study was to evaluate alterations in depressive-like behaviors in rats following chronic administration of a supraphysiological dose of anabolic androgenic steroids (AASs) as well as exposure to a prolonged exercise protocol. …”

Image 1_Effect of dietary supplementation with Brevibacillus laterosporus on broiler growth performance, meat quality and gut microbiome.tif by Haixia Han (336363)

“…Specifically, the HBL group exhibited a notable increase in muscle C18:3n3 content, and a significant decrease in muscle C18:1n9t and C20:3n3 content. …”

EWS/FLI-1 and R1507 influence the activation/expression of key molecules in the IGF-1 signaling pathway. by Helen J. Huang (201553)

“…<p>(a) IGF-BP3 levels increase following transfection of TC-71 cells with EWS/FLI-1 siRNA. …”

PFC and CD68⁺-macrophage accumulation during early infection time course (<b>0–8 dpi</b>). by Stephanie Weibel (127241)

“…(<b>E, H</b>) corresponding confocal-laser microscopic images of tumor sections taken from the intratumoral tissue (center) showed a significant decrease in the density of CD68⁺-macrophages during the time course of infection (12 tumor areas/time point). …”

Image_1_Therapy With Different Dose Regimens of Rituximab in Patients With Active Moderate-To-Severe Graves’ Orbitopathy.tif by Irene Campi (10531166)

“…Primary endpoint was disease inactivation, measured as a decrease of the Clinical Activity Score (CAS) of at least two points. …”

Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection by Sakaorat Lertjuthaporn (5509304)

“…In addition, there was a significant decrease in the level of CD33-expressing mDCs in DENV patients. …”

Data Sheet 2_Global trends in ambient particulate matter-attributable ischemic heart disease among the elderly (1990–2021).csv by Yangxi Zeng (20710481)

“…Although BAPC projections indicate a continued decline, a potential rise in pollution around 2035 may slow the rate of decrease or temporarily flatten the downward trajectory.…”