Data Sheet 1_Acupuncture alleviates hemorrhagic transformation after delayed rt-PA treatment for acute ischemic stroke by regulating the mitophagy-NLRP3 inflammasome pathway.pdf by Tao Jiang (28401)

“…Background<p>The clinical application of recombinant tissue plasminogen activator (rt-PA) is significantly constrained by hemorrhagic transformation (HT), a common and severe complication following thrombolysis for ischemic stroke. …”

Image_2_Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8+ T and NK Cells in Heart Transplant Patients.TIF by Beatriz Díaz-Molina (5791361)

“…Our results imply that only early EVL conversion induces key changes in the post-transplant immune response, preserving an efficient anti-viral response, but simultaneously showing a limited ability to counteract the cytotoxic response to the allograft.…”

Table 1 Primer sequences and amplicon size (base pairs) for SYBR green primers used for RT-PCR. by Jennifer Steiner (10810893)

“…<b>Conclusion:</b> These data suggest that acute alcohol intoxication induced markers of oxidative stress and antioxidant signaling through the NRF2 pathway and that there were effects of alcohol independent of a decrease in food intake caused by binge intoxication.…”

Image_2_Short-Chain Fatty Acids Alleviate Hepatocyte Apoptosis Induced by Gut-Derived Protein-Bound Uremic Toxins.TIF by Mingjuan Deng (11504476)

“…Propionate reduction of apoptosis was associated with improving mitochondria dysfunction and oxidative stress in a manner involving reducing Caspase-3 expression, ROS production, and increasing the Bcl-2/Bax level. …”

Comparison chart of model evaluation results. by Ke Yan (331581)

“…On the other hand, taking English writing teaching as an example, the proposed method is further verified by designing a comparative experiment in groups. The results show that: (1) From the experimental data of word sense disambiguation, the accuracy of the SMOSS-LSTM model proposed in this paper is the lowest when the context range is "3+3", then it rises in turn at "5+5" and "7+7", reaches the highest at "7+7", and then begins to decrease at "10+10"; (2) Compared with the control group, the accuracy of syntactic analysis in the experimental group reached 89.5%, while that in the control group was only 73.2%. (3) In the aspect of English text error detection, the detection accuracy of the proposed model in the experimental group is as high as 94.8%, which is significantly better than the traditional SMOSS-based text error detection method, and its accuracy is only 68.3%. (4) Compared with other existing researches, although it is slightly inferior to Bidirectional Encoder Representations from Transformers (BERT) in word sense disambiguation, this proposed model performs well in syntactic analysis and English text error detection, and its comprehensive performance is excellent. …”

Table 1_Tregs levels and phenotype modifications during Amyotrophic Lateral Sclerosis course.docx by Elisabetta Zucchi (9527077)

“…</p>Discussion<p>Treg levels remained stable during the ALS observation period and were not significantly associated with ALSFRS-r variations, suggesting that Treg numbers alone may have limited utility as a pharmaco-dynamic biomarker for ALS trials. However the observed changes in Treg phenotypes, such as the decrease in PD1+Tregs, indicate that phenotypic variations may warrant further investigation for their potential role in ALS progression and therapeutic targeting.…”

Identification of 5-FU-sensitizing genes. by Tomohiko Sakabe (282459)

“…<p>(A) Determination of a 5-FU concentration sufficient to decrease cell viability in HepG2 cells, which were treated with various concentrations of 5-FU for 72 h. …”

Table_1_Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transc... by Weijie Yang (3625022)

“…Mice were treated with a single dose of CTX (100 mg/kg) at post-natal day 21 and sacrificed 47 days later when primordial follicles surviving chemotherapy developed to the antral stage. …”

Image_1_Endocannabinoids Produced by White Adipose Tissue Modulate Lipolysis in Lean but Not in Obese Rodent and Human.tiff by Chloé Buch (9093966)

“…In the present study, we used different strategies to acutely increase ECS activity in WAT and tested the consequences on glycerol production as a marker of lipolysis. Treating lean mice or rat WAT explants with JLZ195, which inhibits ECs degrading enzymes, induced an increase in 2-AG tissue contents that was associated with a CB1R-dependent decrease in lipolysis. …”

Data Sheet 1_Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis.pdf by Manpreet Singh Atwal (21766919)

“…Together with earlier reports, our findings establish KPNA4 abnormalities as a molecular signature of TDP-43 proteinopathies and identify it as a potential therapeutic target to sustain nuclear TDP-43 essential for cellular homeostasis affected in ALS and frontotemporal dementia.…”

Image_2_Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells.tif by Patrick M. McTernan (341264)

“…These results suggest that ethanol impairs CD4⁺ T cell immunometabolism and disrupts mitochondrial repair processes as it promotes CD4⁺ T cell differentiation to a pro-inflammatory phenotype.</p>…”

Table3_Integrative RNA-Seq and ATAC-Seq Analysis Reveals the Migration-Associated Genes Involved in Antitumor Effects of Herbal Medicine Feiyanning on Lung Cancer Cells.XLSX by Chenyang Wang (170127)

“…Traditional Chinese medicine formula Feiyanning has been clinically administered in China for more than a decade and raised attention due to its anticancer effect in lung cancer. …”

Data_Sheet_1_Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract.docx by James N. D. Battey (10307402)

“…The findings showed an increase in the abundance of Akkermansiaceae upon CS exposure, which was reversed upon cessation. Cessation resulted in a significant decrease in Akkemansiaceae abundance, whereas switching to CHTP 1.2 resulted in an increase in Lactobacillaceae abundance. …”

Data_Sheet_1_Overall Dynamic Body Acceleration in Straw-Colored Fruit Bats Increases in Headwinds but Not With Airspeed.csv by M. Teague O'Mara (6760028)

“…We found that wingbeat frequency has the strongest positive relationship with ODBA. There was a small, but negative, relationship between airspeed and ODBA, and bats decreased ODBA with increasing tailwind. …”

Table_2_miR-344-5p Modulates Cholesterol-Induced β-Cell Apoptosis and Dysfunction Through Regulating Caveolin-1 Expression.docx by Xulong Sun (11195769)

“…<p>Diabetes is a metabolic disorder induced by the modulation of insulin on glucose metabolism, and the dysfunction and decreased number of islets β-cells are the main causes of T2DM (type 2 diabetes mellitus). …”

Table 1_Integrated metabolomic and transcriptomic analysis reveals the biosynthesis mechanism of dihydrochalcones in sweet tea (Lithocarpus litseifolius).xlsx by Shaojun Ling (21979328)

“…Our results revealed an accumulation pattern where DHC levels peaked at stage S3, followed by a sharp decrease at stages S4 and S5, with the exception of sieboldin, which maintained high levels. …”

Table1_TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity.docx by Yun-Yi Li (12031955)

“…Through in vivo isopeptidase activity analysis by rescue expression of SENP1 and its Y270 mutants in a SENP1 CRISPR knockout T cell line, we found that SENP1 Y270F downregulated its isopeptidase activity towards both SUMO1 and SUMO2/3 conjugation by reducing SENP1 binding with sumoylated targets. …”

Table_4_Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8+ T and NK Cells in Heart Transplant Patients.DOCX by Beatriz Díaz-Molina (5791361)

“…Our results imply that only early EVL conversion induces key changes in the post-transplant immune response, preserving an efficient anti-viral response, but simultaneously showing a limited ability to counteract the cytotoxic response to the allograft.…”

The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis by Christine Binquet (403042)

“…The efficiency of such programs is debated increasingly as seroprevalence among pregnant women and incidence of congenital toxoplasmosis show a steady decrease. In addition, uncertainty remains regarding the effectiveness of pre- and postnatal treatments.…”

Data Sheet 1_Direct and indirect effects of land use on microbiomes of trap-nesting solitary bee larvae and nests.docx by Birte Peters (12323923)

“…The Shannon diversity of bacteria in nest materials (larval pollen provision, soil nest enclosure) and larval guts decreased with increasing land use intensity. However, the pupae microbiome remained unaffected, indicating a reorganization of the microbiome during metamorphosis, which is not significantly influenced by land use and available resources.…”