Copy number variation of <i>FCGR</i> genes in etiopathogenesis of sarcoidosis by Marlena Typiak (4003391)

“…However, this immunocomplexemia might also be caused by decreased clearance by immune cells due to a changed copy number of <i>FCGR</i> genes. …”

Altered splicing of GSK3β by <i>Jmjd6</i>a knockdown augments canonical Wnt/β-catenin signaling in <i>Xenopus laevis</i> development. by Jee Yoon Shin (7067369)

“…(B) Knockdown of <i>Jmjd6a</i> induces decreased phosphorylation of β-catenin and increased stability of β-catenin. …”

Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during <i>Mycoplasma Hyopneumoniae</i> infection by Ning Zhang (23771)

“…When the cells system were transfected with vector CTSL-GFP or incubated with recombinant CTSL (rCTSL) before they were infected with <i>Mycoplasma hyopneumoniae</i> (<i>M</i>.<i>hp</i>), SIgA significantly increased and Ii chain was degraded into smaller intermediates, while SIgA decreased when CTSL was knockdown or inhibited with E64. …”

Jmjd6a regulates <i>GSK3β</i> RNA splicing in <i>Xenopus laevis</i> eye development by Jee Yoon Shin (7067369)

“…Knockdown of <i>Jmjd6a</i> by an antisense morpholino resulted in eye malformation including a deformed retinal layer and no lens formation. …”

Expression of human Bcl-xL (Ser49) and (Ser62) mutants in <i>Caenorhabditis elegans</i> causes germline defects and aneuploidy by Prasamit Saurav Baruah (3155196)

“…<div><p>An interesting feature of Bcl-xL protein is the presence of an unstructured loop domain between α1 and α2 helices, a domain not essential for its anti-apoptotic function and absent in CED-9 protein. …”

Knockdown of <i>Jmjd6a</i> leads to various eye defects in <i>Xenopus laevis</i> development. by Jee Yoon Shin (7067369)

“…<p>(A) Injection of <i>Jmjd6</i> MO results in various eye defects (normal to severe) in the injected side of embryos (red arrows) at stage 40 (n = 3). …”

Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization by Kazumi Take (200212)

“…CompA decreased high-fat diet (HFD) intake in C57BL/6J mice. …”

Mice Expressing a "Hyper-Sensitive" Form of the Cannabinoid Receptor 1 (CB₁) Are Neither Obese Nor Diabetic by David J. Marcus (2921505)

“…Therefore, the hypothesis that sustained endocannabinoid signaling can lead to obesity and diabetes was examined in this study using S426A/S430A mutant mice expressing a desensitization-resistant CB₁ receptor. …”

DataSheet_1_Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation.doc... by Andreea C. Mihaila (11252988)

“…S100A9 inhibition with a specific small-molecule blocker, reduced CCL2, CCL3 and CCL5 chemokine expression and decreased MPO and MMP-9 activity, by interfering with the NF-kB signaling pathway. …”

Table_1_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.DOCX by Ebru Karasu (5158097)

“…These data suggest a novel role of the C5a-C5aR1 axis: C5a-induced MV shedding from neutrophils results in decreased C5aR1 surface expression on the one hand, on the other hand it leads to profound inflammatory signals which likely are both key drivers of the neutrophil dysfunction which is regularly observed in patients suffering from multiple traumatic injuries.…”

Image_1_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.TIF by Ebru Karasu (5158097)

“…These data suggest a novel role of the C5a-C5aR1 axis: C5a-induced MV shedding from neutrophils results in decreased C5aR1 surface expression on the one hand, on the other hand it leads to profound inflammatory signals which likely are both key drivers of the neutrophil dysfunction which is regularly observed in patients suffering from multiple traumatic injuries.…”

Image_4_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.TIF by Ebru Karasu (5158097)

“…These data suggest a novel role of the C5a-C5aR1 axis: C5a-induced MV shedding from neutrophils results in decreased C5aR1 surface expression on the one hand, on the other hand it leads to profound inflammatory signals which likely are both key drivers of the neutrophil dysfunction which is regularly observed in patients suffering from multiple traumatic injuries.…”

Image_2_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.TIF by Ebru Karasu (5158097)

“…These data suggest a novel role of the C5a-C5aR1 axis: C5a-induced MV shedding from neutrophils results in decreased C5aR1 surface expression on the one hand, on the other hand it leads to profound inflammatory signals which likely are both key drivers of the neutrophil dysfunction which is regularly observed in patients suffering from multiple traumatic injuries.…”

Image_3_Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.TIF by Ebru Karasu (5158097)

“…These data suggest a novel role of the C5a-C5aR1 axis: C5a-induced MV shedding from neutrophils results in decreased C5aR1 surface expression on the one hand, on the other hand it leads to profound inflammatory signals which likely are both key drivers of the neutrophil dysfunction which is regularly observed in patients suffering from multiple traumatic injuries.…”

Inverse relation between I_basal and R_a arises from the decrease in Gα available for GIRK activation at higher I_basal. by Daniel Yakubovich (823436)

Inhibition of the interaction between Bcl-2 or Bcl-X_L and fluorescent Puma BH3 peptide measured by the decrease of fluorescence polarisation as a function of S44563-2 concentration. by Fariba Némati (3233871)

Image_1_Liquid Chromatography-Tandem Mass Spectrometry Analysis Demonstrates a Decrease in Porins and Increase in CMY-2 β-Lactamases in Escherichia coli Exposed to Increasing Concentrations of Meropenem.JPEG by Dimard E. Foudraine (8041337)

“…Further, it has been shown that Enterobacterales can become resistant to carbapenems when high concentrations of ESBL and AmpC β-lactamases are present in the bacterial cell in combination with a decreased influx of antibiotics (due to a decrease in porins and outer-membrane permeability). …”

Supplementary Material for: Retrospective Analysis of CA19-9 Decrease in Patients with Metastatic Pancreatic Carcinoma Treated with FOLFIRINOX or Gemcitabine in a Randomized Phase III Study (ACCORD11/PRODIGE4) by Robert M. (4493899)

“…<b><i>Conclusion:</i></b> An 8-week CA19-9 decrease ≥20% is a prognostic factor for OS and PFS. …”

Decrease of flowrate over time during plankton filtrations due to increased biomass loading of the filters, as recorded by the Arduino flowmeter (A), and (B) DNA yields after extraction of the corresponding picoplankton filters. by Corentin Fournier (5088941)

Table_2_Liquid Chromatography-Tandem Mass Spectrometry Analysis Demonstrates a Decrease in Porins and Increase in CMY-2 β-Lactamases in Escherichia coli Exposed to Increasing Concentrations of Meropenem.XLSX by Dimard E. Foudraine (8041337)

“…Further, it has been shown that Enterobacterales can become resistant to carbapenems when high concentrations of ESBL and AmpC β-lactamases are present in the bacterial cell in combination with a decreased influx of antibiotics (due to a decrease in porins and outer-membrane permeability). …”