Data_Sheet_1_The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis.PDF by Kelly F. Paton (3934061)

“…In the experimental autoimmune encephalomyelitis model, we found that EOM SalB (0.1–0.3 mg/kg) effectively decreased disease severity in a KOR-dependent manner and led to a greater number of animals in recovery compared to U50,488 treatment. …”

c-Abl Inhibition Delays Motor Neuron Degeneration in the G93A Mouse, an Animal Model of Amyotrophic Lateral Sclerosis by Ryu Katsumata (133006)

“…The survival of G93A mice was improved by oral administration of dasatinib, which also decreased c-Abl phosphorylation, inactivated caspase-3, and improved the innervation status of neuromuscular junctions. …”

Data_Sheet_1_Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.PDF by Yanhua Zhang (356457)

“…In this study, we examined the effects of trichostatin A (TSA), a HDACi, on eosinophilic meningitis induced by A. cantonensis in mice. …”

Table_1_Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.DOCX by Yanhua Zhang (356457)

“…In this study, we examined the effects of trichostatin A (TSA), a HDACi, on eosinophilic meningitis induced by A. cantonensis in mice. …”

Monitoring and understanding chlorophyll-a concentration changes in lakes in northeastern China using MERIS and OLCI satellite data by Lu Zhang (50563)

“…During the study period, 11 lakes exhibited statistically significant increases in Chl-a concentrations (<i>p</i> < 0.05), and 3 lakes showed significantly decreasing trends. …”

Table_3_Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.DOCX by Yanhua Zhang (356457)

“…In this study, we examined the effects of trichostatin A (TSA), a HDACi, on eosinophilic meningitis induced by A. cantonensis in mice. …”

Supplementary Material for: Nrf2- and Bach1 May Play a Role in the Modulation of Ultraviolet A-Induced Oxidative Stress by Acetyl-11-Keto-β-Boswellic Acid in Skin Keratinocytes by Yang S. (3704074)

“…<b><i>Results:</i></b> AKBA reduces UVA irradiation-induced cell viability loss, accompanied by a decreased production of UVA-induced ROS, decreased malondialdehyde, and increased superoxide dismutase expression. …”

Table_2_Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.DOCX by Yanhua Zhang (356457)

“…In this study, we examined the effects of trichostatin A (TSA), a HDACi, on eosinophilic meningitis induced by A. cantonensis in mice. …”

GABA_A receptor-expressing neurons promote consumption in <i>Drosophila melanogaster</i> by Samantha K. Cheung (3897748)

“…Acute activation of these neurons is sufficient to drive consumption of appetitive substances and non-appetitive substances and acute silencing of these neurons decreases consumption. Taken together, these studies identify GABA_A receptor-expressing neurons that promote <i>Drosophila</i> ingestive behavior and provide insight into feeding regulation.…”

Reducing age bias in decision analyses of anticoagulation for patients with nonvalvular atrial fibrillation – A microsimulation study by Matthew A. Pappas (5504363)

“…<div><p>Background</p><p>Anticoagulation decreases a patient’s risk of ischemic stroke and increases the risk of hemorrhage. …”

Drug-induced decrease of cell anisotropy reduces pattern fidelity. by Camille Curantz (7456499)

“…<b>(B)</b> Quantifications of primordia spacing variability on phalloïdin-stained control flat skins (explant; triangles) and LatA-treated cultured explants (+LatA; squares) of Japanese quail embryos showed that LatA treatment caused a significant decrease in pattern fidelity at condensation stage (explants, <i>n</i> = 9; +LatA, <i>n</i> = 9; unpaired 2-tailed <i>t</i> test; <i>p</i> = 0.0233) and differentiation stage (explants, <i>n</i> = 8; +LatA, <i>n</i> = 9; <i>p</i> = 0.002). …”

Parametric Analysis of Gene Set Enrichment identifies Gene Ontology (GO) terms changed in gastrocnemius muscle of 13-month old D257A mice as compared to 13-month old WT mice. by Asimina Hiona (246175)

“…(D) Genes listed within the GO term “electron transport chain” (<i>Z</i>-score = −8.89; p<0.0001) whose expression level significantly (p<0.01) increased (yellow) or decreased (blue) in D257A mice.</p>…”

Table_2_A Small Molecule Inhibitor of CTP Synthetase Identified by Differential Activity on a Bacillus subtilis Mutant Deficient in Class A Penicillin-Binding Proteins.pdf by Kaveh Emami (320085)

“…Two of the three mutant proteins purified showed decreased sensitivity to IQC in vitro. Finally, inhibition by IQC was rescued by addition of cytidine but not uridine to the growth medium, consistent with the notion that IQC acts by reducing the synthesis of CTP or a related compound. …”

Table_1_A Small Molecule Inhibitor of CTP Synthetase Identified by Differential Activity on a Bacillus subtilis Mutant Deficient in Class A Penicillin-Binding Proteins.pdf by Kaveh Emami (320085)

“…Two of the three mutant proteins purified showed decreased sensitivity to IQC in vitro. Finally, inhibition by IQC was rescued by addition of cytidine but not uridine to the growth medium, consistent with the notion that IQC acts by reducing the synthesis of CTP or a related compound. …”

Skin-resident macrophages decrease in number before the onset of anagen. by Donatello Castellana (678749)

“…(D) Fluctuations in the number of perifollicular macrophages during the second hair cycle analyzed by immunofluorescence. Note the decrease in F4/80⁺ at A_VI. Each histogram point represents the mean value of positive cells per 10× magnification field at 30 µm distance from HF <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002002#pbio.1002002-Paus1" target="_blank">[15]</a>. 10 fields/section/mouse were analyzed; <i>n</i> = 4. …”

Image_1_A Small Molecule Inhibitor of CTP Synthetase Identified by Differential Activity on a Bacillus subtilis Mutant Deficient in Class A Penicillin-Binding Proteins.tif by Kaveh Emami (320085)

“…Two of the three mutant proteins purified showed decreased sensitivity to IQC in vitro. Finally, inhibition by IQC was rescued by addition of cytidine but not uridine to the growth medium, consistent with the notion that IQC acts by reducing the synthesis of CTP or a related compound. …”

Image_2_A Small Molecule Inhibitor of CTP Synthetase Identified by Differential Activity on a Bacillus subtilis Mutant Deficient in Class A Penicillin-Binding Proteins.tif by Kaveh Emami (320085)

“…Two of the three mutant proteins purified showed decreased sensitivity to IQC in vitro. Finally, inhibition by IQC was rescued by addition of cytidine but not uridine to the growth medium, consistent with the notion that IQC acts by reducing the synthesis of CTP or a related compound. …”

Image_3_A Small Molecule Inhibitor of CTP Synthetase Identified by Differential Activity on a Bacillus subtilis Mutant Deficient in Class A Penicillin-Binding Proteins.tif by Kaveh Emami (320085)

“…Two of the three mutant proteins purified showed decreased sensitivity to IQC in vitro. Finally, inhibition by IQC was rescued by addition of cytidine but not uridine to the growth medium, consistent with the notion that IQC acts by reducing the synthesis of CTP or a related compound. …”

Image_4_A Small Molecule Inhibitor of CTP Synthetase Identified by Differential Activity on a Bacillus subtilis Mutant Deficient in Class A Penicillin-Binding Proteins.tif by Kaveh Emami (320085)

“…Two of the three mutant proteins purified showed decreased sensitivity to IQC in vitro. Finally, inhibition by IQC was rescued by addition of cytidine but not uridine to the growth medium, consistent with the notion that IQC acts by reducing the synthesis of CTP or a related compound. …”

Data_Sheet_1_Functional Division Between the RecA1 and RecA2 Proteins in Myxococcus xanthus.pdf by Duo-Hong Sheng (8441805)

“…Deletion of recA1 did not affect the growth but significantly decreased the UV-radiation survival, homologous recombination (HR) ability, and induction of LexA-dependent SOS genes. …”