Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination by Tatenda Kadungure (782562)

“…By retroviral transduction of mutant AID proteins into <i>aid</i>^<i>-/-</i> mouse splenic B cells, we show that 4 amino acids within the C terminus of mouse AID, when individually mutated to specific amino acids (R190K, A192K, L196S, F198S), reduce CSR about as much or more than deletion of the entire C terminal 10 amino acids. …”

Effects of local cardiac denervation on cardiac innervation and ventricular arrhythmia after chronic myocardial infarction by Xudong Liu (6899)

“…Our study suggests that this methodology might decrease malignant ventricular arrhythmia in chronic MI, and has a great potential for clinical application.…”

Kainate receptor (KAR) antagonism rescues the loss of endogenous 3-HK and promotes lysosomal acidification in infected macrophages. by Emily R. Goering (22486572)

“…<p><b>(A)</b> KAR antagonism with NS 3763 rescues the sensitivity to infection in <i>kmo</i> morphants. …”

DataSheet_3_Green tea extract suppresses airway inflammation via oxidative stress-driven MAPKs/MMP-9 signaling in asthmatic mice and human airway epithelial cells.xlsx by Jeong-Won Kim (18464976)

“…</p>Results<p>The GTE100 and GTE400 groups showed a decrease in airway hyperresponsiveness and the number of inflammatory cells in the bronchoalveolar lavage fluid (BALF) compared to the OVA group. …”

Data_Sheet_1_Vacuolar nitrate efflux requires multiple functional redundant nitrate transporter in Arabidopsis thaliana.pdf by Yu-Ting Lu (8490249)

“…Further analysis showed that the sextuple mutant (npf5.10 npf5.14 npf8.5 npf5.11 npf5.12 npf5.16) had a higher ¹⁵NO3-uptake rate than the wild-type Col-0, but no significant difference was observed for nitrate accumulation between them. …”

The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice by John D. Belcher (190588)

“…Microvascular stasis was measured in subcutaneous venules in NY1DD and HbSS-Townes SCD mice with dorsal skin-fold chambers after infusion of hemoglobin or exposure to hypoxia/reoxygenation. 2FF in drinking water or administered by gavage inhibited stasis in sickle mice in a dose-responsive manner. Significant inhibitory effects on stasis were seen 1 day post-treatment. 2FF treatment of SCD mice also significantly reduced leukocyte rolling and adhesion along the vessel walls of SCD mice and the static adhesion of neutrophils and sickle red blood cells isolated from 2FF-treated SCD mice to resting and activated endothelial cells. …”

Changes in Birth Weight between 2002 and 2012 in Guangzhou, China by Yong Guo (169213)

“…</p><p>Conclusions</p><p>Among local population in Guangzhou from 2002 to 2012, birth weight appeared to slightly decrease. The percentage of SGA and LGA also simultaneously dropped, indicating that newborns might gain a healthier weight for gestational age.…”

Table_3_The Impact of Particulate Matter (PM2.5) on Human Retinal Development in hESC-Derived Retinal Organoids.XLSX by Yuxiao Zeng (770249)

“…It demonstrated that the formation rate of the hERO-derived neural retina (NR) was affected by PM2.5 in a concentration dosage-dependent manner. The areas of hEROs and the thickness of hERO-NRs were significantly reduced after PM2.5 exposure at the concentration of 25, 50, and 100 μg/ml, which was due to the decrease of proliferation and the increase of apoptosis. …”

Synergistic Anti-Tumor Effects of Combination of Photodynamic Therapy and Arsenic Compound in Cervical Cancer Cells: In Vivo and In Vitro Studies by Yong-Wan Kim (136883)

“…PDT or As₄O₆ significantly inhibited TC-1 cell proliferation in a dose-dependent manner (<em>P</em><0.05) by MTT assay. …”

Table_4_Mucosal-Associated Invariant T Cell Features and TCR Repertoire Characteristics During the Course of Multiple Sclerosis.docx by Edgar Carnero Contentti (7900313)

“…These findings may contribute to a better understanding of pathophysiological phenomena underlying the course of MS, and discovery of MAIT cell inhibitors could pave the way for the development of new therapeutic strategies.…”

Table_1_Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients.DOCX by Taoyang Yuan (8470440)

“…</p>Results<p>Compared with healthy controls, both patient groups exhibited (1) a large cluster of voxels with gray matter (GM) volume decrease in the contralesional MTL using region of interest (ROI)-based VBM analysis (cluster level p < 0.05, FDR corrected); and (2) decreased intrahemispheric FC between the posterior hippocampus (pHPC) and posterior cingulate cortex (PCC) (p < 0.01, Bonferroni corrected). …”

Immunodetection of Lung IgG and IgM Antibodies against SARS-CoV‑2 via Enzymatic Liquefaction of Respiratory Samples from COVID-19 Patients by Antonio Clemente (2998128)

“…The suitability of the enzymatic method for detecting antibodies in respiratory samples is demonstrated by detecting anti-SARS-CoV-2 IgG and IgM to viral N-protein with gold standard ELISA in bronchial aspirate specimens from a multicenter cohort of 44 COVID-19 patients. The enzymatic detection sharply increases the sensitivity toward IgG and IgM detection compared to the traditional approach based on liquefying samples with dithiothreitol. …”

Image_1_Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment.tif by Faqi Wang (2072857)

“…This study adds to the evidence that LIFUS could become a promising and non-invasive treatment strategy for the clinical treatment of central nervous system diseases related to cognitive impairments in the future.…”

Diastolic Heart Failure Predicted by Left Atrial Expansion Index in Patients with Severe Diastolic Dysfunction by Shih-Hung Hsiao (3117576)

“…For predicting HFpEF, the LAEI had a hazard ratio of 1.197per 10% decrease. In patients who had HFpEF events, the LAEI significantly (<i>P</i>< 0.0001) decreased from 69±18% to 39±11% during hospitalization. …”

Table_2_Transcriptome Profiling of the Elongating Internode of Cotton (Gossypium hirsutum L.) Seedlings in Response to Mepiquat Chloride.xlsx by Li Wang (15202)

“…In summary, we confirmed the important role of GA in MC-induced growth inhibition of cotton, and further found that other hormones were also involved in this process in a GA-dependent manner. This study provides novel insights into the molecular mechanism underlying the MC-mediated inhibition of internode elongation in cotton seedlings.…”

Image_2_Mucosal-Associated Invariant T Cell Features and TCR Repertoire Characteristics During the Course of Multiple Sclerosis.pdf by Edgar Carnero Contentti (7900313)

“…These findings may contribute to a better understanding of pathophysiological phenomena underlying the course of MS, and discovery of MAIT cell inhibitors could pave the way for the development of new therapeutic strategies.…”

miRNA-524-5p was target of nifedipine and regulated the expression of BRI3. by Dong-Qing Guo (667396)

“…<p>a) Predicted duplex formation between human BRI3 3′-UTR (top) and three miRNA (bottom) including has-miRNA-524-5p, hsa-miR-1224-3p, hsa-miR-1229 by using TargetScan software. b) The expression of miRNA-524-5p decreased in the MDA-MB-231 cells treated with nifedipine for different periods. …”

Weight and histopathological analyses of WT and homozygous VCP^R155H/R155H mice. by Angèle Nalbandian (131106)

“…<p>(A) VCP^R155H/R155H mice are much smaller and weaker and demonstrate gross abnormalities such as hairless areas with ichthyosis-like thickening of the superficial layers of the skin compared to their WT littermates at day 14. …”

Recording of Influenza-Like Illness in UK Primary Care 1995-2013: Cohort Study by Pia Hardelid (355911)

“…<div><p>Background</p><p>There is a lack of recent studies examining recording of influenza-like illness (ILI) in primary care in the UK over time and according to population characteristics. …”

Dynamic and Cell-Infiltratable Hydrogels as Injectable Carrier of Therapeutic Cells and Drugs for Treating Challenging Bone Defects by Qian Feng (302178)

“…We believe that this is the first demonstration on applying injectable hydrogels as effective carriers of therapeutic cargo for treating dysfunctions in deep and enclosed anatomical sites via a minimally invasive procedure.…”