Table 2_The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI.docx by Rida Rehman (11120838)

“…We have previously demonstrated that several members of the Fibroblast Growth Factor Receptor (FGFR) family are transiently phosporylated upon TBI; the availability for drug repurposing of FGFR inhibitors makes worthwhile the elucidation of the role of FGFR in the acute phases of the response to TBI and the effect of FGFR inhibition.</p>Methods<p>A closed, blunt, weight-drop mild TBI protocol was employed. …”

Image1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Then, SZV-1287 (20 mg/kg/day) or its vehicle was injected intraperitoneally over a 21-day period.</p>Results<p>MIA induced remarkable weight bearing and paw withdrawal threshold decrease, alterations in the tibial and femoral structures (decreased trabeculation and cortical erosions), histopathological damage (disorganized cartilage structure, hypocellularity, decreased matrix staining, disrupted tidemark integrity, synovial hyperplasia, and osteophyte formation), and changes in the astrocyte and microglia density in the lumbar spinal cord.…”

2024-05-05 Raw data "Comparison of the effects between catalase and superoxide dismutase on regulating macrophage inflammatory response and protecting osteogenic function of period... by Bijun Zhu (16553019)

“…Inflammation levels were assessed by real-time quantitative polymerase chain reaction (RT-qPCR) and western blot. A co-culture system of macrophages and PDLCs was established, and the osteogenic differentiation of PDLCs was evaluated by alkaline phosphatase staining, alizarin red S staining, RT-qPCR and Western blot. …”

Image_4_Bacteroides thetaiotaomicron Ameliorates Experimental Allergic Airway Inflammation via Activation of ICOS+Tregs and Inhibition of Th2 Response.tif by Wenhui Pang (394103)

“…Therefore, our data indicate that oral administration of B. thetaiotaomicron effectively inhibited the development of AAD in murine model; inhibition was mediated by the activation of Tregs and inhibition of Th2 response without promoting a Th1 response.</p>…”

Data_Sheet_6_Coral-Derived Endophytic Fungal Product, Butyrolactone-I, Alleviates Lps Induced Intestinal Epithelial Cell Inflammatory Response Through TLR4/NF-κB and MAPK Signaling... by Shengwei Chen (1764178)

Variability of soil characteristics around an active volcano, Mt. Mayon in the Philippines with special reference to the distance and direction from the crater by Sarrah D. Sambajon (17987992)

“…Soil profiles were prepared at four and six sites in different directions, on a circle of 6 km and 15 km away from the crater, respectively. …”

Image_3_The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease.tif by Fangyan Wang (6410591)

“…In vitro, butyrate, not acetate or propionate, increased the expression of phosphatase MKP-1 to dephosphorylate activated JNK, ERK1/2 and p38 MAPK against excessive inflammation in RAW264.7 macrophages. It suggests a new insight into probiotics and their metabolites supplements to treat KD.…”

Table6_BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate.XLSX by Ruiqi Liu (3873832)

“…B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), one of spermatogonial stem cell markers, is a member of Polycomb repressive complex 1 (PRC1) and important to spermatogenesis. …”

Image_1_Inhibitory and excitatory responses in the dorso-medial prefrontal cortex during threat processing.TIF by Venkata C. Chirumamilla (6792758)

“…At source level, ICF led to an increase and short intracortical inhibition (SICI) to a decrease of theta power in the bilateral dmPFC, relative to single pulse TMS during 0–0.5 s. …”

DataSheet1_Integrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention.ZIP by Zhaoming Zhu (8136090)

“…These results propose action mechanisms for the use of CPT in acne, as a safe and potential new drug.</p>…”

DataSheet_3_Phyllolobium chinense Fisch Flavonoids (PCFF) Suppresses the M1 Polarization of LPS-Stimulated RAW264.7 Macrophages by Inhibiting NF-κB/iNOS Signaling Pathway.docx by Hua Fan (495346)

“…</p>Conclusion<p>P. chinense Fisch flavonoids (PCFF) have a remarkable inhibitory effect on the inflammatory response in acute injured zebrafish and LPS-stimulated M1 RAW264.7 macrophage. …”

Table2_Effects of frog skin peptide temporin-1CEa and its analogs on ox-LDL induced macrophage-derived foam cells.DOCX by Xue-Feng Yang (5278559)

“…Frog skin AMPs inhibited foaming formation by reducing the protein expression of CD36, which regulates ox-LDL uptake but had no effect on the expression of efflux proteins ATP binding cassette subfamily A/G member 1 (ABCA1/ABCG1). Then, decreased mRNA expression of NF-κB and protein expression of p-NF-κB p65, p-IκB, p-JNK, p-ERK, p-p38 and the release of TNF-α and IL-6 occurred after exposure to the three frog skin AMPs.…”

DataSheet_1_Radiofrequency ablation plays double role in immunosuppression and activation of PBMCs in recurrent hepatocellular carcinoma.doc by Yang Zhao (39052)

“…The down-regulation of GZMB, GZMH, GZMK, and CD8A, which are involved in the cytotoxic function of T cells, was observed following RFA. …”

Image 1_The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI.tif by Rida Rehman (11120838)

“…We have previously demonstrated that several members of the Fibroblast Growth Factor Receptor (FGFR) family are transiently phosporylated upon TBI; the availability for drug repurposing of FGFR inhibitors makes worthwhile the elucidation of the role of FGFR in the acute phases of the response to TBI and the effect of FGFR inhibition.</p>Methods<p>A closed, blunt, weight-drop mild TBI protocol was employed. …”

Table 2_Transcriptomic and metabolomic analysis of carotenoid metabolism and accumulation of carotenoid-derived products in tobacco leaves before and after curing.xlsx by Tao Liu (10785)

“…Significant difference in CDPs levels occurs between varieties of distinct genetic background and between regions with different ecological conditions. In order to have a better understanding of what are the major factors that influence the accumulation of CDPs in tobacco leaves, four tobacco varieties, K326, NC82, G28, and Gexin3, with different aroma characteristics, were grown in two typical fields in Shandong and Yunnan, two major tobacco-producing areas in northern and southern China, respectively. …”

Table1_Identification of biomarkers and potential drug targets in osteoarthritis based on bioinformatics analysis and mendelian randomization.XLSX by Feng Cheng (124653)

“…Further refinement identified two core genes (ARL4C and GAPDH), whose expression levels were found to decrease in OA pathology and exhibited a protective effect in the MR analysis, thus demonstrating consistent trends. …”

Image_4_Differential Action of Reelin on Oligomerization of ApoER2 and VLDL Receptor in HEK293 Cells Assessed by Time-Resolved Anisotropy and Fluorescence Lifetime Imaging Microsco... by Paula Dlugosz (6400175)

“…Details of this pathway are still not fully understood since the participating components are highly variable and create a complex mixture of interacting molecules. Reelin is proteolytically processed resulting in five different fragments some of which carrying the binding site for two different but highly homologous receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR). …”

Data_Sheet_1_In vitro Bactericidal Activities of Combination Antibiotic Therapies Against Carbapenem-Resistant Klebsiella pneumoniae With Different Carbapenemases and Sequence Type... by Jocelyn Qi-Min Teo (3148467)

“…Thus, combination therapy remains a suitable treatment option. We aimed to evaluate the in vitro bactericidal activity of various antibiotic combinations against CRKP with different carbapenemase genotypes and sequence types (STs). …”

Image_1_Fecal Microbiota Alterations Associated With Diarrhea-Predominant Irritable Bowel Syndrome.PDF by Xiaojun Zhuang (5556374)

“…Furthermore, rifaximin induced alterations of some special bacteria rather than affected the overall composition of microbiota in IBS-D patients. Meanwhile, a potential decrease in propanoate and butanoate metabolism was found in these IBS-D patients after rifaximin treatment. …”

Crystallographic Distinction between “Contact” and “Separated” Ion Pairs:  Structural Effects on Electronic/ESR Spectra of Alkali-Metal Nitrobenzenides by Milya G. Davlieva (2720230)

“…Such a loss in electronic conjugation (or reverse charge transfer) may be counterintuitive, but it is in agreement with the distribution of odd-electron spin electron density from the ESR data and with the hypsochromic shift of the characteristic absorption band in the electronic spectra. …”