Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress by Béatrice Chambraud (3371201)

“…</p> <p><b>Abbreviations:</b> AD: Alzheimer disease; AKT/protein kinase B: AKT serine/threonine kinase; ALP: Autophagy-lysosomal pathway; ATG: autophagy-related; BafA₁: bafilomycin A₁; CQ: chloroquine; CTSD: cathepsin D; DIV: days in vitro; DRG: dorsal root ganglion neurons; Dox: doxycycline; DNAJC5: DnaJ heat shock protein family (Hsp40) member C5; EL: empty lentiviral vectors; ENO2/NSE: enolase 2, gamma neuronal; FKBP4/FKBP52: FKBP prolyl isomerase 4; FTLD-Tau: frontotemporal lobar degeneration with Tau pathology; GFP: green fluorescent protein; LAMP1: lysosomal associated membrane protein 1; LDH: lactate dehydrogenase; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAPT/Tau: microtubule associated protein tau; MTT: tetrazolium salt; NFTs: neurofibrillary tangles; RPE-1: retinal pigment epithelial cells; shRNA: small-hairpin ribonucleic acid; SQSTM1/p62: sequestosome 1; SD: standard deviation; SEM: standard error of the mean; SH-SY5Y: human neuroblastoma cells; Sh1 or Sh2: Lentiviral shRNA vectors inducing FKBP4 decrease; SH-52GFP: MAPT/Tau-inducible SH-SY5Y cell line constitutively expressing FKBP4-GFP; TUBB3/βIII tubulin: tubulin beta 3 class III; UPS: ubiquitin-proteasome system</p>…”

Flow Chart of Study Participant Selection. by Zhi Jin (3742471)

“…Notably, individuals with long sleep duration (>9 hours) had a significantly decreased risk of CVD (OR: 0.36, 95% CI: 0.15–0.85, P = 0.02) compared to those with shorter sleep durations.…”

IgG and age. by Hiromi Yamaguchi (2396248)

Data_Sheet_1_Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment.docx by Takeshi Ikeuchi (397119)

“…</p>Conclusion<p>The PFAA profile, especially decreases in BCAAs and His, is associated with development of AD in MCI participants, and the difference was larger in the APOE ε4-negative population, suggesting that the PFAA profile is an independent risk indicator for AD development. …”

Meta-regressions of significant factors influencing heart rate variability in untreated hypothyroid patients (exhaustive metaregressions are presented in S5 Fig). by Valentin Brusseau (12769704)

<i>Listeria monocytogenes</i> downregulates ferroportin by a hepcidin-independent mechanism. by Rodrigo Abreu (9745691)

Heat map showing differential abundance of fecal metabolites in various study groups (Panels A-D): Metabolites profiles for Atm-KO-CM group, Atm-KO-RM, WT-CM, and WT-RM, respective... by Amrita K. Cheema (515119)

Significant decreased cell divisions in D4 FCRL4⁺ cells compared to D4 FCRL4^- cells. by Michel Jourdan (687539)

“…Results were processed with the ModFit Lt software to determine the number of cell divisions. (<b>A</b>) Representative experiment. The mean number of cell divisions is indicated. …”

Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women by Vijay, Ganji

“…In multivariable adjusted analysis, no association was found between serum 25(OH)D concentration and bone mass when serum 25(OH)D was categorized. In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. …”
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women by Vijay, Ganji

“…In multivariable adjusted analysis, no association was found between serum 25(OH)D concentration and bone mass when serum 25(OH)D was categorized. In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. …”
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Temporal changes in IgG. by Hiromi Yamaguchi (2396248)

Treatment of MCMV infected neonates with dexamethasone decreases infiltration of inflammatory cells and expression of interferon stimulated genes in the CNS without increasing leve... by Kate Kosmac (386527)

Microinjection solution (200 µM bicuculline+10 µM SR101) concentration decreases with distance and does not directly affect contralateral cortex. by Jeffrey Walker (331808)

Regions within sox11 contributing to caspase-6 activity decreases include amino acids 117–214, as well as the c-terminal transactivation domain. by Elaine Waldron-Roby (520491)

The expression of PrP^C on mouse bone marrow (BM) and spleen erythroid precursors is upregulated in early erythroblasts and, then, decreases with the cells' maturation. by Martin Panigaj (345008)

“…The initial increase of expression is followed by its decrease on late basophilic and polychromatic erythroblasts (EryB), and most mature small precursors (EryC) express a low number of PrP^C. …”

Effects of a chronic administration of E2, P4 and combined treatment on the uteri and vagina of mice. by Marie-Cécile Valéra (4014953)

A Framework for Proactive Interaction in Automated Vehicles by Jinglu Li (16487649)

“…However, there is little guidance on how vehicles should behave proactively, or even a shared understanding of what that means. Using prior work, we develop a framework of proactive interaction comprising three dimensions: initiation of action, alignment with users’ goals, and communication of context awareness. …”

PRL increases anterior pituitary cells apoptosis <i>in vivo</i> and decreases the percentage of total anterior pituitary cells in G2/M-phase. by Jimena Ferraris (314722)

Oncologic outcomes between neoadjuvant and control groups. by Chinock Cheong (6853004)

Risk of bias assessment. by Delai Zheng (18468980)