Voluntary wheel running can lead to modulation of immune checkpoint molecule expression by Marie Lund Bay (9382997)

“…</p> <p> B16 tumors displayed upregulated expression of immune regulatory molecules and decreased tumor growth in response to PA. However, combining PA with PD-1 or PD-L1 blockade did not lead to a further augmented inhibition of tumor growth.…”

NF-κB p65 and phosphorylation of IκBα <i>in vitro</i>. by Naoki Takada (2728912)

“…<p>(A) The enzyme-linked immunosorbent assay (ELISA) results showed that p65 concentration in the radiation group was higher than that in the control group (NOZ: 2,398.4 ± 62.8 ng/mg protein vs. 923.5 ± 42.3 ng/mg protein, p < 0.01; OCUG-1: 2,609.3 ± 409.3 ng/mg protein vs. 1,899.5 ± 99.5 ng/mg protein, p < 0.05). p65 concentration in the combination group was lower than that in the radiation group (NOZ: 1,256.1 ± 13.0 ng/mg protein vs. 2,398.4 ± 62.8 ng/mg protein, p < 0.01; OCUG-1: 1,250.9 ± 117.8 ng/mg protein vs. 2,609.3 ± 409.3 ng/mg protein, p < 0.01). …”

Video_6_Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues.mp4 by Laura Moreno de Lara (12966254)

“…HIV induced NET formation through non-lytic pathways in blood and FGT neutrophils, except for a small subset of NETs that incorporated annexin V and lactoferrin predominantly in blood, suggesting proinflammatory and lytic NET release. …”

Image_3_Alterations of Gut Microbiome and Metabolite Profiles Associated With Anabatic Lipid Dysmetabolism in Thyroid Cancer.tif by Ganghua Lu (12750878)

“…LEfSe analysis demonstrated that genera (g_Christensenellaceae_R-7_group, g_Eubacterium_coprostanoligenes_group) and metabolites [27-hydroxycholesterol (27HC), cholesterol] closely related to lipid metabolism were greatly reduced in the TC group. In addition, a clinical serum indicator (total cholesterol) and metabolites (27HC and cholesterol) had the strongest influence on the sample distribution. …”

Image_5_Linking between soil properties, bacterial communities, enzyme activities, and soil organic carbon mineralization under ecological restoration in an alpine degraded grassla... by Xiangyang Shu (15190342)

“…Overall, our study provides insights into soil biotic and abiotic factors in association with SOC mineralization, and contributes to understanding the effect and mechanism of ecological restoration on SOC mineralization in a degraded grassland in an alpine region.</p>…”

Natural reversal of pulmonary vascular remodeling and right ventricular remodeling in SU5416/hypoxia-treated Sprague-Dawley rats by Makhosazane Zungu-Edmondson (302496)

“…<div><p>Aims</p><p>Pulmonary arterial hypertension (PAH) is a lethal disease and improved therapeutic strategies are needed. …”

Image2_The TCM Preparation Feilike Mixture for the Treatment of Pneumonia: Network Analysis, Pharmacological Assessment and Silico Simulation.jpg by Juqin Peng (12158061)

“…<p>The Feilike mixture (FLKM) is a valid prescription that is frequently used to assist in the clinical treatment of pneumonia. …”

Table_3_Identification, Characterization, and Transcriptional Reprogramming of Epithelial Stem Cells and Intestinal Enteroids in Simian Immunodeficiency Virus Infected Rhesus Macaq... by Nongthombam Boby (4255957)

“…Understanding the molecular mechanisms underlying the disrupted epithelial regeneration might provide an alternative approach for the treatment of HIV-mediated enteropathy and immune activation. We have observed a significant increased presence of α defensin5+ (HD5) Paneth cells and proliferating Ki67+ epithelial cells as well as decreased expression of E-cadherin expression in epithelial cells during SIV infection. …”

Table_2_Identification and Characterization of Biomarkers and Their Role in Opioid Addiction by Integrated Bioinformatics Analysis.XLSX by Xiuning Zhang (9698756)

“…The importance and originality of this study are provided by two aspects. Firstly, we used a variety of calculation methods to obtain hub genes; secondly, we exploited homology analysis to solve the difficult challenge that addiction-related experiments cannot be carried out in patients or healthy individuals. …”

Table2_Integrated Transcriptome and Multiple Activated Pathways in Endometrial Cancer.XLSX by Qi Jin (12159)

“…The aim of this study was to explore the abnormal expression profile of genes during the development of endometrial cancer, which is essential to provide a better understanding of the mechanisms involved. …”

Image 1_COVID-19 mitigates the response to TKIs in patients with CML via the inhibition of T-cell immunity.pdf by Na He (295300)

“…Introduction<p>Chronic myeloid leukemia (CML) is a severe hematological malignancy characterized by BCR-ABL fusion gene. …”

Slicing aided hyper inference algorithm. by Chunhua Yang (346871)

“…<div><p>This study proposes the S-YOLOv10-ASI algorithm to improve the accuracy of tea identification and harvesting by robots, integrating a slice-assisted super-reasoning technique. The algorithm improves the partial structure of the YOLOv10 network through space-to-depth convolution. …”

Table_2_Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy.DOCX by Kui-Fang Du (10141512)

“…Retinal, retinal nerve fiber layer-ganglion cell layer-inner plexiform layer (RNFL-GCL-IPL), RNFL, GCL-IPL, and INL thickness showed a negative association with the duration of HIV diagnosis or antiretroviral therapy (ART) (all p < 0.05). …”

High Incubation Temperature and Threonine Dietary Level Improve Ileum Response Against Post-Hatch <i>Salmonella</i> Enteritidis Inoculation in Broiler Chicks by Alexandre Lemos de Barros Moreira Filho (763998)

“…After hatch, chicks were distributed according to a 3x2+1 factorial arrangement (three temperatures and two threonine levels and one sham-inoculated control). …”

Table_3_The glycoside hydrolase gene family profile and microbial function of Debaryomyces hansenii Y4 during South-road dark tea fermentation.DOCX by Yao Zou (452727)

“…It was hypothesized that D. hansenii Y4 is likely to be an important functional microbe targeting carbohydrate destruction and catechin transformation during SSDT pile-fermentation, with DEHA2G08602g as a key thermotolerant functional gene.</p>…”

Image_3_Crab bioturbation reduces carbon storage in salt marshes under more robust mechanisms than plant invasiveness.jpeg by Yujie Hua (3614390)

“…Therefore, crab bioturbation is a more significant factor affecting carbon sink capacity than plant invasion.…”

Table_1_Transcriptome Analysis Revealed Overlapping and Special Regulatory Roles of RpoN1 and RpoN2 in Motility, Virulence, and Growth of Xanthomonas oryzae pv. oryzae.DOCX by Chao Yu (562804)

“…<p>σ⁵⁴ factor (RpoN) plays a crucial role in bacterial motility, virulence, growth, and other biological functions. …”

Data_Sheet_1_Short-Term Grazing Exclusion Alters Soil Bacterial Co-occurrence Patterns Rather Than Community Diversity or Composition in Temperate Grasslands.docx by Fangfang Wang (330843)

“…Moreover, our study suggested that soil bacterial co-occurrence patterns were more sensitive to grazing exclusion, and the restoration of soil bacterial community might need a long term (>4 years) in our study area.</p>…”

Table_1_Physiological and lipidomic response of exogenous choline chloride alleviating salt stress injury in Kentucky bluegrass (Poa pratensis).docx by Zhi-Fang Zuo (11447266)

“…Introduction<p>Choline participates in plant stress tolerance through glycine betaine (GB) and phospholipid metabolism. As a salt-sensitive turfgrass species, Kentucky bluegrass (Poa pratensis) is the main turfgrass species in cool-season areas.…”

Table_1_NtMYB4 and NtCHS1 Are Critical Factors in the Regulation of Flavonoid Biosynthesis and Are Involved in Salinity Responsiveness.DOCX by Shuai Chen (506142)

“…These results suggested that tobacco NtMYB4 acts as a salinity response repressor and negatively regulates NtCHS1 expression, which results in the reduced flavonoid accumulation and weakened ROS-scavenging ability under salt stress.…”