Image_1_Systemic Oxidative Stress, Aging and the Risk of Cardiovascular Events in the General Female Population.TIFF by Martin F. Bourgonje (10115305)

“…<p>Introduction: Menopause is associated with increased cardiovascular risk, in which oxidative stress plays a pivotal role. Systemic oxidative stress is reflected by decreased levels of free thiols (R-SH, sulfhydryl groups), which are key components of the extracellular antioxidant machinery. …”

Image_1_5-FU-Induced Upregulation of Exosomal PD-L1 Causes Immunosuppression in Advanced Gastric Cancer Patients.TIF by Min Zhang (111999)

“…<p>Although the cytotoxic chemotherapeutic agent 5-fluorouracil (5-FU) is generally considered to directly kill cancer cells and exert immunostimulatory effects in advanced gastric cancer, accumulating evidence indicates that it upregulates the expression of PD-L1, a representative immune checkpoint blockade molecule involved in negative regulation of the immune response. …”

Table_2_Dietary omega-3 polyunsaturated fatty acids reduce cytochrome c oxidase in brain white matter and sensorimotor regions while increasing functional interactions between neur... by Carley Rivers (19986186)

Image_2_Activation of CXCL6/CXCR1/2 Axis Promotes the Growth and Metastasis of Osteosarcoma Cells in vitro and in vivo.JPEG by Guangchen Liu (332117)

“…<p>Osteosarcoma (OS) is a malignant primary bone tumor with high metastatic rate. …”

Overview of VDR-mediated regulation of cytokine transcription, production and secretion in immune cells. by Emily K. Calton (821151)

“…VDR association with the promoter region occurs in a cyclic fashion, which leads to initial gene suppression, followed by upregulation of IL-2 and IL-10 expression after 48 hours. …”

Image_4_Hypoxia-Inducible Factor 1α and 2α Have Beneficial Effects in Remote Ischemic Preconditioning Against Stroke by Modulating Inflammatory Responses in Aged Rats.TIF by Xiangnan Du (8552319)

“…ACF also reversed the activation of the Akt signaling pathway induced by RIPC following stroke. HIF may play a key role in RIPC, which was likely mediated by the Akt signaling pathway and systemic modulation of the inflammatory response in aged rats.…”

Data Sheet 1_Neonatal encephalopathy due to birth asphyxia and trauma: global trends and disparities.pdf by Fengling Du (22229149)

“…Background<p>Neonatal encephalopathy due to birth asphyxia and trauma (NE-BAT) is a leading cause of neonatal mortality and long-term neurodevelopmental disabilities, particularly in low- and middle-income regions.…”

DataSheet_5_SCM-198 Prevents Endometriosis by Reversing Low Autophagy of Endometrial Stromal Cell via Balancing ERα and PR Signals.zip by Yi-Kong Lin (12882812)

“…</p>Results<p>Increased estrogen-estrogen receptor (ER) α signaling and decreased progesterone receptor isoform B (PRB) expression synergistically led to a hypo-autophagy state in eESCs, which further inhibited the apoptosis of eESCs. …”

Urine Bacterial Community Convergence through Fertilizer Production: Storage, Pasteurization, and Struvite Precipitation by Rebecca H. Lahr (3217476)

“…Illumina 16S rRNA gene sequencing revealed a complex community of bacteria in fresh urine that differed across collection events. …”

Image2_Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice.TIF by Lu Xia (1509745)

“…</p><p>Conclusion: GSDMD-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures. Our study provides a new potential therapeutic target for seizure control.…”

Table 5_Rapid reshaping of the soil microbiome and metabolome during short-term flooding and draining in rice.xlsx by Yanyao Lu (22163632)

“…However, the specific effects of different drainage durations on soil microorganisms and metabolites remain unclear. This study adopted a multi-omics research method. After nontargeted metabolomics analysis of lipids as the main metabolite, microbial diversity analysis and lipidomics analysis were conducted to determine the main influencing factors. …”

Image_3_Risk stratification based on DNA damage-repair-related signature reflects the microenvironmental feature, metabolic status and therapeutic response of breast cancer.tif by Chunzhen Li (14835418)

“…Integrating public datasets and bioinformatics algorithms, we developed a robust prognostic signature based on 27 DRGs. …”

DataSheet_1_Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues.pdf by Hamza Atcha (11464924)

“…Together, this study demonstrates that the physical environment synergizes with biochemical cues to regulate macrophage morphology and function, and suggests a role for CD11b and Piezo1 crosstalk in mechanotransduction in macrophages.…”

Table1_Metformin reduces basal subpopulation and attenuates mammary epithelial cell stemness in FVB/N mice.DOCX by Minghui Shan (19068320)

“…These insights suggest that the regulatory effects of metformin on premalignant mammary tissues could potentially delay or prevent the onset of breast cancer, offering a promising avenue for developing new preventive strategies.…”

DataSheet1_Ablation Patterns of the Debris Covered Tongue of Halong Glacier Revealed by Short Term Unmanned Aerial Vehicle Surveys.docx by Wanqin Guo (450937)

“…The surface ablation rates show a clear negative exponential relationship with the measured debris thicknesses, well in accordance with previous studies. …”

Image 1_Evaluation of degree centrality and neurological outcomes in patients with herpes simplex encephalitis.tif by Dongzhi Liu (2747134)

“…The National Institutes of Health Stroke Scale (NIHSS), the Glasgow Coma Scale (GCS), and the modified Rankin Scale (mRS) were assessed for all HSE patients.</p>Results<p>A total of 70 HSE patients and 76 controls were included in our data analysis. …”

Table_3_The Impact of Chronic Heat Stress on the Growth, Survival, Feeding, and Differential Gene Expression in the Sea Urchin Strongylocentrotus intermedius.DOC by Yaoyao Zhan (359351)

“…Further Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analyses revealed that these DEGs mainly enriched the functional categories of ribosome, protein processing in endoplasmic reticulum, and prion diseases. A total of 732 temperature-induced expressed genes, such as ATP5, heat shock protein 70, and heat shock protein 90, were identified as candidates that were closely correlated with heat resistance in S. intermedius. …”

Table_1_Narrow-Margin Hepatectomy Resulted in Higher Recurrence and Lower Overall Survival for R0 Resection Hepatocellular Carcinoma.docx by Lihong Liu (337889)

“…Patients with narrow margin showed a tendency of decreased OS than those with wide margin (P<0.001). …”

P-values of the hourly <i>d</i>_<i>e</i> index. by Nicola Rossi (16679179)

“…High environmental temperatures were found to be associated with a bimodal pattern in daily activity, which was closely linked to the daily variations in the thermal quality of the habitat; whereas the pattern and frequency of social displays showed less plasticity. …”

DataSheet4_Single-cell transcriptome dynamics of the autotaxin-lysophosphatidic acid axis during muscle regeneration reveal proliferative effects in mesenchymal fibro-adipogenic pr... by Osvaldo Contreras (780538)

“…<p>Lysophosphatidic acid is a growth factor-like bioactive phospholipid recognising LPA receptors and mediating signalling pathways that regulate embryonic development, wound healing, carcinogenesis, and fibrosis, via effects on cell migration, proliferation and differentiation. …”