Image 1_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…<p>Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. …”

Table_3_Long-term menopause exacerbates vaginal wall support injury in ovariectomized rats by regulating amino acid synthesis and glycerophospholipid metabolism.xlsx by Xia Yu (486142)

“…Purpose<p>Menopause is a risk factor for pelvic organ prolapse (POP) and is frequently associated with diminished vaginal wall support. …”

KSHV oral shedding and plasma viremia result in significant changes in the extracellular tumorigenic miRNA expression profile in individuals infected with the malaria parasite by Minako Ikoma (4843458)

“…Proteome analysis indicated an exosomal protein profile consistent with erythrocyte and keratinocyte origins for the plasma exosomes. A strong correlation was observed between the abundance of Plasmodium proteins and cellular markers of malaria. …”

Image_2_Diabetic macrophage small extracellular vesicles-associated miR-503/IGF1R axis regulates endothelial cell function and affects wound healing.tif by Jianqiang Wang (573651)

“…<p>Diabetic foot ulcer (DFU) is a break in the skin of the foot caused by diabetes. …”

Image1_Neurotrophin-4 promotes the specification of trophectoderm lineage after parthenogenetic activation and enhances porcine early embryonic development.TIF by Mirae Kim (6448016)

“…<p>Neurotrophin-4 (NT-4), a neurotrophic factor, appears to affect early embryonic development because it is secreted not only by neurons but also by oviductal and uterine epithelial cells. …”

Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer by Hongjun Guan (4840134)

“…<p>Non-small cell lung cancer (NSCLC) is a common malignant tumor, with high morbidity and mortality. …”

Molecular characterization of tsetse’s proboscis and its response to <i>Trypanosoma congolense</i> infection by Erick O. Awuoche (4603582)

“…These results suggest that PB is a muscular organ with chemosensory and mechanosensory capabilities. …”

Image_1_Diabetic macrophage small extracellular vesicles-associated miR-503/IGF1R axis regulates endothelial cell function and affects wound healing.tif by Jianqiang Wang (573651)

“…<p>Diabetic foot ulcer (DFU) is a break in the skin of the foot caused by diabetes. …”

Table_1_Enhanced Prefrontal Neuronal Activity and Social Dominance Behavior in Postnatal Forebrain Excitatory Neuron-Specific Cyfip2 Knock-Out Mice.DOCX by Yinhua Zhang (111234)

“…Nevertheless, filamentous actin (F-actin) levels were increased only in L5 of Cyfip2 cKO mPFC possibly because of a compensatory increase in CYFIP1, the other member of CYFIP family, in L2/3 neurons. …”

DataSheet_1_Antitumor Effects and the Compatibility Mechanisms of Herb Pair Scleromitrion diffusum (Willd.) R. J. Wang–Sculellaria barbata D. Don.docx by Li Lu (68660)

“…In vivo antitumor effects of HD-SB were much more potent than either of the two single herbs in Panc28 xenograft mice model. A total 29 active ingredients involved in antitumor effects were selected from HD and SB, and the “herb–composition–target–disease” network was constructed. …”

Infected cells in tissue and myeloid clusters. by Xiaoke Xu (3468623)

“…This infection can lead to neurological effects and establish a viral reservoir. Given the gaps in our understanding of how these cells respond <i>in vivo</i> to acute CNS infection, we conducted single-cell RNA sequencing (scRNA-seq) on myeloid cells from the brains of three rhesus macaques 12 days after SIV infection, along with three uninfected controls. …”

How Does Recycling of Livestock Manure in Agroecosystems Affect Crop Productivity, Reactive Nitrogen Losses, and Soil Carbon Balance? by Longlong Xia (1680154)

“…However, how substituting livestock manure for synthetic N fertilizer affects crop productivity (crop yield; crop N uptake; N use efficiency), reactive N (Nr) losses (ammonia (NH₃) emission, N leaching and runoff), GHG (methane, CH₄; and nitrous oxide, N₂O; carbon dioxide) emissions and soil organic carbon (SOC) sequestration in agroecosystems is not well understood. We conducted a global meta-analysis of 141 studies and found that substituting livestock manure for synthetic N fertilizer (with equivalent N rate) significantly increased crop yield by 4.4% and significantly decreased Nr losses via NH₃ emission by 26.8%, N leaching by 28.9% and N runoff by 26.2%. …”

Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas by Cynthia Stretch (586403)

“…</p><p>Methods</p><p>Clinical characteristics and outcomes were studied in 123 patients who underwent pancreaticoduodenectomy for pancreatic or non-pancreatic periampullary adenocarcinoma and who had available preoperative CT scans. In a subgroup of patients with pancreatic cancer (n = 29), <i>rectus abdominus</i> muscle mRNA expression was determined by cDNA microarray and in another subgroup (n = 29) ¹H-NMR spectroscopy and gas chromatography-mass spectrometry were used to characterize the serum metabolome.…”

Table9_α-Mangostin Alleviated HIF-1α-Mediated Angiogenesis in Rats With Adjuvant-Induced Arthritis by Suppressing Aerobic Glycolysis.XLSX by Tian-Tian Jiang (11857058)

“…<p>A previously validated anti-rheumatic compound α-mangostin (MAN) shows significant metabolism regulatory effects. …”

The Long Noncoding RNA MALAT-1 Is Highly Expressed in Ovarian Cancer and Induces Cell Growth and Migration by Yanqing Zhou (3166842)

“…Downregulation of MALAT-1 resulted in significant change of gene expression (at least 2-fold) in 449 genes, which regulate proliferation, cell cycle, and adhesion. As a consequence of MALAT-1 knockdown, MMP13 protein expression decreased, while the expression of MMP19 and ADAMTS1 was increased.…”

Data_Sheet_2_Chronic alcohol-induced dysbiosis of the gut microbiota and gut metabolites impairs sperm quality in mice.ZIP by Hui Li (32376)

“…Sperm quality was significantly decreased in the alcohol-FMT group compared with the control-FMT group. …”

Alumazene Adducts with Pyridines:  Synthesis, Structure, and Stability Studies by Jiri Löbl (2485519)

“…The planarity of the alumazene ring is lost upon coordination of the Lewis base molecules. A comparison of the Al−N(base) bond distances and pyramidality at Al suggests the higher basicity of dmap. …”

Table_1_Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D-Galactose-Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota-Gut-... by Baiyan Liu (12869393)

“…Liuwei Dihuang decoction (LW), a commonly applied Chinese medicine formula, is widely used for the treatment of aging-related diseases in China. …”

Image 2_Increases in the susceptibility of human endometrial CD4+ T cells to HIV-1 infection post-menopause are not dependent on greater viral receptor expression frequency.jpeg by Landon G. vom Steeg (13794506)

“…Here, we evaluated how menopause-associated changes in CD4⁺ T cell numbers and subsets as well as HIV coreceptor expression, particularly CCR5, in the endometrium (EM), endocervix (CX), and ectocervix (ECX) may alter HIV infection susceptibility. Using a tissue-specific mixed cell infection model, we demonstrate that while no changes in CD14⁺ macrophage infection susceptibility were observed, CD4⁺ T cell HIV-1 infection frequency increases following menopause in the EM, but not CX nor ECX. …”

Alumazene Adducts with Pyridines:  Synthesis, Structure, and Stability Studies by Jiri Löbl (2485519)

“…The planarity of the alumazene ring is lost upon coordination of the Lewis base molecules. A comparison of the Al−N(base) bond distances and pyramidality at Al suggests the higher basicity of dmap. …”