Image 4_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…<p>Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. …”

Image_1_Identification and validation of key molecules associated with humoral immune modulation in Parkinson’s disease based on bioinformatics.tif by Na Xing (823501)

“…</p>Methods<p>Firstly, we performed a series of bioinformatic analyses utilizing the expression profile of the peripheral blood mononuclear cell (PBMC) obtained from the GEO database (GSE100054, GSE49126, and GSE22491) to identify differentially expressed genes related to humoral immune regulatory mechanisms between PD and healthy controls. …”

T follicular helper cells regulate the activation of B lymphocytes and antibody production during <i>Plasmodium vivax</i> infection by Maria Marta Figueiredo (338454)

“…<i>vivax</i>) infection and if they play a role during disease remains unknown. Our goal was to define the role of Tfh cells during <i>P</i>. …”

Image_4_An in vitro Model of Human Retinal Detachment Reveals Successive Death Pathway Activations.tif by Jelena Potic (9693587)

“…Almost no Cleaved-Caspase3 signal was observed, whereas a transient augmentation at day 3 of AIF-positive cells was observed to be about 10-fold in comparison to the control group (n = 2). …”

Alteration of mRNA abundance, oxidation products and antioxidant enzyme activities during oocyte ageing in common carp <i>Cyprinus carpio</i> by Azin Mohagheghi Samarin (6392774)

“…The lack of response of both activities of antioxidant enzymes and oxidation products during oocyte ageing strengthens the conclusion that oxidative stress is unlikely to be a main factor determining the progress of oocyte ageing in common carp. …”

Data_Sheet_2_Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D-Galactose-Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota... by Baiyan Liu (12869393)

“…Liuwei Dihuang decoction (LW), a commonly applied Chinese medicine formula, is widely used for the treatment of aging-related diseases in China. …”

Data_Sheet_2_Single-cell transcriptome revealed dysregulated RNA-binding protein expression patterns and functions in human ankylosing spondylitis.docx by Zheng Ren (1766506)

“…</p>Results<p>(1) Compared with the HC group, the numbers of B, DC (dendritic cells), CD14⁺ Mono and CD8⁺ T cells were increased in AS group, while the numbers of platelet (platelets), CD8⁺ NKT, CD16⁺ Mono (non-classical monocytes), Native CD4⁺ T and NK were decreased. (2) Through the analysis of RBP genes in B cells, some RBPs were found to play an important role in B cell differentiation and function, such as DDX3X, SFPQ, SRRM1, UPF2. (3) It may be related to B-cell receptor, IgA immunity, NOD-like receptor and other signaling pathways; Through the analysis of RBP genes in CD8⁺ T cells, some RBPs that play an important role in the immune regulation of CD8⁺ T were found, such as EIF2S3, EIF4B, HSPA5, MSL3, PABPC1 and SRSF7; It may be related to T cell receptor, TNF, IL17 and other signaling pathways. (4) Based on bulk RNA-seq, it was found that compared with HC and AS patients, differentially expressed variable splicing genes (RASGs) may play an important role in the occurrence and development of AS by participating in transcriptional regulation, protein phosphorylation and ubiquitination, DNA replication, angiogenesis, intracellular signal transduction and other related pathways.…”

Table_6_Antioxidant Activity and the Potential Mechanism of the Fruit From Ailanthus altissima Swingle.XLSX by Ya-nan Mo (11829002)

“…<p>The fruits of Ailanthus altissima Swingle (AS) possess a variety of pharmacological activities. Its antioxidant activity and the potential mode of action have not yet been investigated. …”

DataSheet_1_AURKA inhibitor-induced PD-L1 upregulation impairs antitumor immune responses.docx by Bi Meng (16970205)

“…</p>Results<p>We found that AURKA inhibitor MLN8237 promoted the expression of PD-L1 in a time- and concentration-dependent manner while exerted its antitumor effect. …”

Image_2_Effects of Intranasal Oxytocin on Pup Deprivation-Evoked Aberrant Maternal Behavior and Hypogalactia in Rat Dams and the Underlying Mechanisms.jpg by Xiao Yu Liu (1264464)

“…<p>Oxytocin (OT), a hypothalamic neuropeptide, applied through nasal approach (IAO), could improve maternal health during lactation that is disrupted by mother–baby separation; however, the regulation of IAO effects on maternal behaviors and lactation as well as the underlying mechanisms remain unclear. …”

Table_1_METH-Induced Neurotoxicity Is Alleviated by Lactulose Pretreatment Through Suppressing Oxidative Stress and Neuroinflammation in Rat Striatum.docx by Xiao-Li Xie (5922641)

“…<p>Abuse of methamphetamine (METH) results in neurological and psychiatric abnormalities. Lactulose is a poorly absorbed derivative of lactose and can effectively alleviate METH-induced neurotoxicity in rats. …”

Table_1_Global, regional, and national years lived with disability due to blindness and vision loss from 1990 to 2019: Findings from the Global Burden of Disease Study 2019.docx by Shasha Li (139491)

“…Purpose<p>This study aimed to provide a comprehensive assessment of burden estimates and the secular trend of blindness and vision loss, as measured by years lived with disability (YLDs), at the global, regional, and national levels.…”

DataSheet1_Thermodynamics and Kinetics of pH-dependent Dissolution of Sparingly Soluble Alkaline Earth Hydroxides in Source-Separated Human Urine Collected in Decentralised Sanitat... by Prithvi Simha (9366341)

“…Within the emerging niche of source-separating sanitation, these chemicals have found a new application—to prevent urease-catalysed degradation of urea present in freshly excreted human urine. …”

Data_Sheet_1_IL-6 and IL-8 Are Linked With Myeloid-Derived Suppressor Cell Accumulation and Correlate With Poor Clinical Outcomes in Melanoma Patients.pdf by Richard P. Tobin (7840187)

Image_5_Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI.png by Neftali Ramirez (13251924)

“…In steady state, naïve B cells had increased cell death pathways and reduced cell metabolism pathways, while after stimulation, enhanced immune responses and decreased cell survival were detected. Using a multi-omics approach, our findings provide valuable insights into the impaired biology of naïve B cells from TACI mutation carriers.…”

An HIV-1 Envelope Immunogen with W427S Mutation in CD4 Binding Site Induced More T Follicular Helper Memory Cells and Reduced Non-Specific Antibody Responses by Hao-Tong Yu (697936)

“…We constructed a gp120 mutant W427S of an HIV-1 primary R5 strain and examined its ability in the elicitation of Ab and the production of Tfh by immunization of BALB/c mice. …”

DataSheet1_Synergistic effects of SAP and PGPR on physiological characteristics of leaves and soil enzyme activities in the rhizosphere of poplar seedlings under drought stress.pdf by Dawei Jing (18515707)

“…However, the effects of SAP co-applied with PGPR on the physiological characteristics of leaves and rhizosphere soil enzyme activities of poplar seedlings are not well understood. Here, a pot experiment using one-year-old poplar seedlings with five treatments, normal watering, drought stress (DR), drought stress + SAP (DR+SAP), drought stress + Priestia megaterium (DR +PGPR) and drought stress + SAP + P. megaterium (DR+S+P), was performed to analyze the contents of non-enzymatic antioxidants, osmotic regulators and hormones in leaves, as well as rhizosphere soil enzyme activities. …”

Table_10_Preliminary prediction of semen quality based on modifiable lifestyle factors by using the XGBoost algorithm.docx by Mingjuan Zhou (12880019)

“…Then, machine learning with the XGBoost algorithm was applied to establish a primary prediction model by using the collected data. …”

Table1_Shifting Trade-offs: Finding the Sustainable Nexus of Hydropower and Environmental Flows in the San Joaquin River Watershed, California.XLSX by Ann D. Willis (11307490)

“…The functional flow strategy allocated water in a holistic approach that enhanced ecological functions in all years, but particularly in moderate and wet years. …”

Characteristics of study participants. by Gagandeep Kaur Walia (8374872)

“…<div><p>Background</p><p>More than 250 loci have been identified by genome-wide scans for type 2 diabetes in different populations. South Asians have a very different manifestation of the diseases and hence role of these loci need to be investigated among Indians with huge burden of cardio-metabolic disorders. …”