<i>Hirsutella sinensis</i> Attenuates Aristolochic Acid-Induced Renal Tubular Epithelial-Mesenchymal Transition by Inhibiting TGF-β1 and Snail Expression by Xiao-yi Xu (2150326)

“…These results suggest Snail might be a potential target of HS effect.</p><p>Conclusion</p><p>HS is able to antagonize, to some extent, tubular EMT and renal interstitial fibrosis caused by AA, which might be related to its inhibitory effects on the TGF-β1 and Snail expression.…”

Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress by Hammad, Ayat Samir

“…Our findings indicate that exposure to tunicamycin (0.5 µg/mL) for 2 hours induces the expression of GRP78 and CHOP, and causes a significant reduction in renal cell viability. …”
Get full text

DataSheet_1_Suppression of microRNA-222-3p ameliorates ulcerative colitis and colitis-associated colorectal cancer to protect against oxidative stress via targeting BRG1 to activat... by Xue-jun Wang (280169)

“…Recent studies have indicated that microRNA-222-3p (miR-222-3p) is increased in colon of UC and colorectal cancer (CRC) patients, and miR-222-3p is a crucial regulator of oxidative stress. However, whether miR-222-3p influences IEC oxidative stress in UC and CAC remains unknown. …”

Data Sheet 1_Environmental surveillance of the health risk of PM2.5-bound metals and metalloids in Wuxi, China, from 2020 to 2023.docx by Lijun Chen (313408)

“…<p>PM_2.5 has been a major public concern due to its association with various diseases; however, its contamination is still not well controlled. …”

Data_Sheet_1_RNA sequencing-based identification of the regulatory mechanism of microRNAs, transcription factors, and corresponding target genes involved in vascular dementia.PDF by Kaiyue Zhao (11795684)

“…Five miRNAs (miR-5132-5p, miR-764-3p, miR-223-3p, miR-145-5p, and miR-122-5p), ten TFs (Mxi1, Nfatc4, Rxrg, Zfp523, Foxj2, Nkx6-1, Klf4, Klf5, Csrnp1, and Prdm6), and seven target genes (Serpine1, Nedd4l, Pxn, Col1a1, Plec, Trip12, and Tpm1) were chosen as the significant nodes to construct feed-forward loops (FFLs). …”

Sleep phenotypes of flies with <i>dbt</i> down regulation only during adulthood. by Jialin Wang (490082)

“…<p>(A) Sleep profile of flies with adult specific reduction of <i>dbt</i> level. …”

Information S1 - Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor by Akiko Murakami (515972)

“…Treatment with YC-1 significantly decreased the number of HIF1α-positive cells in a dose-dependent manner. …”

Use of ⁷⁷Se and ¹²⁵Te NMR Spectroscopy to Probe Covalency of the Actinide-Chalcogen Bonding in [Th(E_<i>n</i>){N(SiMe₃)₂}<sub>... by Danil E. Smiles (1861267)

“…We also recorded the ⁷⁷Se NMR shift for a U­(VI) oxo-selenido complex, [U­(O)­(Se)­(NR₂)₃]⁻ (δ­(⁷⁷Se) = 4905 ppm), which features the highest frequency ⁷⁷Se NMR shift yet reported, and expands the known ⁷⁷Se chemical shift range for diamagnetic substances from ∼3300 ppm to almost 6000 ppm. …”

Activity of Major Neural Networks and Hypothesized Molecular Processes Occurring During Wake, NREM Sleep, and REM Sleep by Emmanuel Mignot (31065)

“…</p> <p>(A) Wakefulness. During wakefulness, monoaminergic, hypocretinergic, and cholinergic systems are active and contribute to EEG desynchronization through thalamic and cortical projections. …”

Data_Sheet_1_Effects of Dietary Yucca Schidigera Extract and Oral Candida utilis on Growth Performance and Intestinal Health of Weaned Piglets.docx by Zhenguo Yang (786974)

“…The purpose of this study was to explore the effects of dietary yucca schidigera extract (YSE) and oral Candida utilis (CU) on growth performance and intestinal health weaned piglets. According to a 2 × 2 factorial design with the main factors being CU (orally administered 1 mL of 0.85% saline with or without CU; fed basal diet with or without 120 mg/kg YSE), forty 28 d healthy weaned piglets were randomly allocated into four groups of 10 barrows each: (1) piglets fed basal diet and orally administered 1 mL of 0.85% saline (CON); (2) piglets fed basal diet and orally administered 1 mL 1 × 10⁹ cfu/mL C. utilis in 0.85% saline (CU); (3) piglets fed the basal diet containing YSE (120 mg/kg) and orally administered 1 mL of 0.85% saline (YSE); (4) Piglets fed the basal diet containing 120 mg/kg YSE and 1 mL 1 × 10⁹ cfu/mL C. utilis in 0.85% saline (YSE+CU). …”

Contributions of direct versus indirect mechanisms for regulatory dendritic cell suppression of asthmatic allergen-specific IgG1 antibody responses by Yanna Ma (4730493)

“…Herein we assessed the mechanism(s) by which DC10 and DC10-induced Treg affect IgG1 production in asthma. We observed a rapid decline in lung-resident OVA-specific IgG1-secreting B cells on cessation of airway allergen challenge, and intraperitoneal DC10 therapy did not amplify that (p>0.05). …”

Sero-Molecular Epidemiology of Japanese Encephalitis in Zhejiang, an Eastern Province of China by Jin-ren Pan (3079326)

“…</p><p>Methodology/Principal Findings</p><p>A total of 570 serum specimens were sampled from community population aged from 0 to 92 years old in Xianju county of Zhejiang Province in 2013–2014. …”

Impact of Fixed Nitrogen Availability on Dehalococcoides mccartyi Reductive Dechlorination Activity by Devrim Kaya (8039411)

“…These findings demonstrate that biostimulation with NH₄⁺ can enhance <i>Dhc</i> reductive dechlorination rates; however, a “do nothing” approach that relies on indigenous diazotrophs can achieve similar dechlorination end points and avoids the potential for stalled dechlorination due to inhibitory levels of NH₄⁺ or transformation products (i.e., nitrous oxide).…”

Data_Sheet_1_Preliminary Results on the Long-Term Effects of Dextromethorphan on MDMA-Mediated Serotonergic Deficiency and Volumetric Changes in Primates Based on 4-[18F]-ADAM PET/... by Skye Hsin-Hsien Yeh (12565243)

“…This study aimed to evaluate the long-term neurotoxicity of MDMA after 66 months abstinence and explored whether Dextromethorphan, a non-competitive N-methyl-D-aspartate (NMDA) receptor, could attenuate MDMA-induced neurotoxicity using 4-[¹⁸F]-ADAM, an imaging ligand that selectively targets SERT, with positron emission tomography technology (PET). …”

Knock out VGLL4 in valvar endothelial cells leads to hypertrophy and compromised heart function on later stage. by Wei Yu (43094)

“…<p>(A) Gross front view of hearts from 9-month-old <i>Tie2</i>^<i>Cre+</i><i>;Vgll4</i>^<i>fl/-</i> and <i>Vgll4</i>^<i>fl/-</i> control hearts. …”

Data_Sheet_1_Profile of Histone H3 Lysine 4 Trimethylation and the Effect of Lipopolysaccharide/Immune Complex-Activated Macrophages on Endotoxemia.docx by Vichaya Ruenjaiman (8278671)

“…<p>Macrophage plasticity is a process that allows macrophages to switch between two opposing phenotypes based on differential stimuli. …”

Transcriptome Analysis Reveals Regulation of Gene Expression for Lipid Catabolism in Young Broilers by Butyrate Glycerides by Fugui Yin (550649)

“…Bioinformatic analysis with both IPA and DAVID-BR further revealed a significant enrichment of DEGs and TSEGs in the biological processes for reducing the synthesis, storage, transportation and secretion of lipids in the jejunum, while those in the liver were for enhancing the oxidation of ingested lipids and fatty acids. …”

HLA high-resolution typing by next-generation sequencing in Pandemrix-induced narcolepsy by Alexander Lind (5221088)

“…In total, 15 alleles, four extended haplotypes, and six genotypes were found to be increased or decreased in frequency among NT1 patients compared to GP. …”

Interactions among P7-1 of SRBSDV, BAP31 and DnaJB11. by Xiangzhen Yu (9741548)

“…<p>(A) Structural features and domains of DnaJB11 and BAP31 from <i>S</i>. …”

Exercise adaptations in <i>Drosophila</i> require Octopamine <i>β1</i> receptors in muscle. by Alyson Sujkowski (183927)

“…<p><b>(A)</b><i>MHC GS> Octβ1R</i> RNAi have lower baseline endurance than age-matched RU- control flies (log-rank, p = 0.0058). …”