Image_5.TIF by Lorena Pizarro (396472)

“…Overexpression of SlPRA1A strongly decreases LeEIX2 endosomal localization, as well as LeEIX2 protein levels. …”

DataSheet_1_Metabolic Engineering to Improve Docosahexaenoic Acid Production in Marine Protist Aurantiochytrium sp. by Disrupting 2,4-Dienoyl-CoA Reductase.docx by Shitong Liang (13049235)

“…Impressively, the KO strain yielded 21.62% more neutral lipids and 57.34% greater DHA production; moreover, the opposite was observed when overexpressing DECR (OE strain), with significant decreases of 30.49% and 64.61%, respectively. Furthermore, the KO strain showed a prolonged DHA production period with a sustainable increase from 63 to 90 h (170.03 to 203.27 mg g⁻¹ DCW), while that of the wildtype strain decreased significantly from 150.58 to 140.10 mg g⁻¹ DCW. …”

Image_1.TIF by Lorena Pizarro (396472)

“…Overexpression of SlPRA1A strongly decreases LeEIX2 endosomal localization, as well as LeEIX2 protein levels. …”

DataSheet_2_Metabolic Engineering to Improve Docosahexaenoic Acid Production in Marine Protist Aurantiochytrium sp. by Disrupting 2,4-Dienoyl-CoA Reductase.docx by Shitong Liang (13049235)

“…Impressively, the KO strain yielded 21.62% more neutral lipids and 57.34% greater DHA production; moreover, the opposite was observed when overexpressing DECR (OE strain), with significant decreases of 30.49% and 64.61%, respectively. Furthermore, the KO strain showed a prolonged DHA production period with a sustainable increase from 63 to 90 h (170.03 to 203.27 mg g⁻¹ DCW), while that of the wildtype strain decreased significantly from 150.58 to 140.10 mg g⁻¹ DCW. …”

Image_6.TIF by Lorena Pizarro (396472)

“…Overexpression of SlPRA1A strongly decreases LeEIX2 endosomal localization, as well as LeEIX2 protein levels. …”

Fast 3D shape screening of large chemical databases through alignment-recycling-8 by Fabien Fontaine (75372)

“…</p><p></p>sented by black boxes, and also at lower cut-offs until a similar number of hits are found, represented by grey boxes. retrieves a similar number of hits (grey boxes cut the 1.0 ratio line) by decreasing the shape Tanimoto threshold by 0.01, 0.008 and 0.006 at 0.75, 0.80 and 0.85, respectively. …”

The relationship between baseline uric acid and time-averaged uric acid. by Shunya Uchida (770154)

“…<p>The regression line is depicted in black line and a unity of the slope is overlapped in a dotted line. …”

Effects of Aprepitant on the Pharmacokinetics of Controlled-Release Oral Oxycodone in Cancer Patients by Yutaka Fujiwara (615517)

“…<div><p>Purpose</p><p>Oxycodone is a µ-opioid receptor agonist widely used in the treatment of cancer pain. …”

Two distinct patterns: Theoretical framework of the association between CSF Aβ42 and CSF Tau. by Aysha S. Mohamed Lafirdeen (6697244)

“…<p>In green, patients with normal profiles have an increase of CSF Aβ42 followed by a decrease after the progression of tau pathology. …”

CaeA suppresses T cell activation and IFN-γ secretion. by Arvind K. Singla (149527)

“…Value in the inset indicates percentage; (B) bar diagram depicts decreased percentage of CD4 T cells expressing CD69; (C) ELISA data depicted as pg/ml shows decrease in IFN-γ secretion by CaeA. ‘*’ represents p<0.05. …”

Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways... by So Youn Park (141327)

“…Time-dependent increases in the expression of JAK2 phosphorylated at Tyr1007/1008 (P-JAK2) in activated N2a Swe cells. <b>C</b> and <b>D</b>. Concentration-dependent decreases in P-JAK2 expression by taxifolin (10 ~ 50 μM), cilostazol (10 ~ 50 μM), and 20 μM AG490 (a JAK2 inhibitor) determined after culture in medium containing 1% FBS for 3 hr. …”

DataSheet1_Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells.docx by Monivan Chhour (10773384)

“…Herein, we documented the modulation of the toxicity of the quinone menadione on a genetically modified neuroblastoma model cell line that expresses both the quinone oxidoreductase 2 (NQO2, E.C. 1.10.5.1) alone or together with the conjugation enzyme UDP-glucuronosyltransferase (UGT1A6, E.C. 2.4.1.17), one of the two UGT isoenzymes capable to conjugate menadione. …”

Making Benzotrithiophene a Stronger Electron Donor by Xin Guo (123593)

“…A new member of the benzotrithiophene family, benzo[2,1-<i>b</i>:-3,4-<i>b</i>′:5,6-<i>c</i>″]trithiophene (<b>3a</b>), and its alkyl substituted derivatives (<b>3b</b>–<b>e</b>) were synthesized and characterized. …”

Making Benzotrithiophene a Stronger Electron Donor by Xin Guo (123593)

“…A new member of the benzotrithiophene family, benzo[2,1-<i>b</i>:-3,4-<i>b</i>′:5,6-<i>c</i>″]trithiophene (<b>3a</b>), and its alkyl substituted derivatives (<b>3b</b>–<b>e</b>) were synthesized and characterized. …”

Murine embryonic fibroblasts arrest in G₂ in response to etoposide treatment. by Jorge Boucas (741520)

“…<p><b>(A)</b> Gene expression changes identified by RNA-Seq following 6h of treatment with 20μM etoposide were analyzed for enrichments in GO terms. …”

Khsrp-dependent regulation of <i>Cdkn1a</i>^<i>P21</i>. by Jorge Boucas (741520)

“…<p><b>(A)</b> Cell cycle analysis and <b>(B)</b> mitotic index of wildtype and <i>Khsrp</i>^{<b><i>-/-</i></b>} MEFs expose a <i>Khsrp</i>-dependent <b>(A)</b> accumulation of cells in G_<b>1</b> and <b>(B)</b> decreased cycling rates. …”

DataSheet_1_Characterization and Neuroprotection Potential of Seleno-Polymannuronate.pdf by Decheng Bi (8470335)

“…Moreover, Se-PM decreased the expression of cytochrome c and the ratio of Bax to Bcl-2, and enhanced the mitochondrial membrane potential in N2a-sw cells. …”

Eukaryotic RNA binding protein hnRNPH1 suppresses influenza A virus replication through interaction with virus NS1 protein by Jinyu Wang (381467)

“…<p>The NS1 protein of influenza A virus (IAV) is a multi-functional protein which can antagonize host immune system and facilitate viral replication by interacting with host factors. …”

Table_2_Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome.XLS by Zheying Min (5618366)

“…Most notably, differentially acetylated proteins were significantly enriched in the metabolic pathways of glycolysis, fatty acid degradation, TCA cycle, tryptophan metabolism, and branched-chain amino acid degradation. Acetyl-CoA acetyltransferase 1 (ACAT1) was an enzyme central to these metabolic pathways with increased acetylation level in the PCOS group, and there was a negative correlation of ACAT1 acetylation levels in PCOS granulosa cells with oocyte quality and embryo development efficiency in the clinic. …”

Table_3_Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome.XLS by Zheying Min (5618366)

“…Most notably, differentially acetylated proteins were significantly enriched in the metabolic pathways of glycolysis, fatty acid degradation, TCA cycle, tryptophan metabolism, and branched-chain amino acid degradation. Acetyl-CoA acetyltransferase 1 (ACAT1) was an enzyme central to these metabolic pathways with increased acetylation level in the PCOS group, and there was a negative correlation of ACAT1 acetylation levels in PCOS granulosa cells with oocyte quality and embryo development efficiency in the clinic. …”