A Genetically Hard-Wired Metabolic Transcriptome in <em>Plasmodium falciparum</em> Fails to Mount Protective Responses to Lethal Antifolates by Karthikeyan Ganesan (269200)

“…It was of interest to learn how DNA microarrays may be used to study drug action in malaria parasites. In one large, tightly controlled study involving 123 microarray hybridizations between cDNA from isogenic drug-sensitive and drug-resistant parasites, a lethal antifolate (WR99210) failed to over-produce RNA for the genetically proven principal target, dihydrofolate reductase-thymidylate synthase (DHFR-TS). …”

Data_Sheet_1_Wastewater Treatment Works: A Last Line of Defense for Preventing Antibiotic Resistance Entry Into the Environment.docx by Keira Tucker (12549307)

“…Sul1 and sul2 gene copies increased in cultures enriched in sub-MIC concentrations of sulfamethoxazole, while bla_KPC decreased after exposure to amoxicillin. It was concluded, within the parameters of this study, that WWTW assist in reducing ARG and ARB, but that sub-inhibitory exposure to antimicrobials has a varied effect on ARG copy number in pure cultures.…”

Loss of presynaptic dTip60 in the nervous system results in a reduction of acetylated microtubules in axons extending into terminal boutons. by Jessica Sarthi (199376)

“…Of note, acetylated microtubule staining as a whole was decreased in dTip60^E431Q larvae (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026202#pone-0026202-g007" target="_blank">Figure 7 C and D</a>). …”

Table_1_N2b Reflects the Cognitive Changes in Executive Functioning After Concussion: A Scoping Review.pdf by Sophie N. Krokhine (9856721)

“…The aims of this review are to consolidate an understanding of the cognitive functions reflected by the N2b and to account for discrepancies in literature findings regarding the N2b and concussion.</p><p>Methods: A scoping review was conducted on studies that used the N2b to measure cognitive functioning in healthy control populations, as well as in people with concussions.…”

Image_1_Pseudo-Meigs’ syndrome secondary to breast cancer with ovarian metastasis: a case report and literature review.tif by Xiang-Ying Lin (15424493)

“…Color Doppler ultrasound examination revealed a mass approximately 109×89 mm in size in the right adnexal area, accompanied by multiple uterine fibroids and a large amount of pelvic and peritoneal effusions. …”

Table_1_N2b Reflects the Cognitive Changes in Executive Functioning After Concussion: A Scoping Review.pdf by Sophie N. Krokhine (9856721)

“…The aims of this review are to consolidate an understanding of the cognitive functions reflected by the N2b and to account for discrepancies in literature findings regarding the N2b and concussion.</p><p>Methods: A scoping review was conducted on studies that used the N2b to measure cognitive functioning in healthy control populations, as well as in people with concussions.…”

<em>EBP1</em> Is a Novel E2F Target Gene Regulated by Transforming Growth Factor-β by David Judah (166627)

“…<div><p>Regulation of gene expression requires transcription factor binding to specific DNA elements, and a large body of work has focused on the identification of such sequences. …”

Data_Sheet_1_Potential Correlation Between Eczema and Hematological Malignancies Risk: A Systematic Review and Meta-Analysis.docx by Zuohui Liang (9218011)

“…Background<p>Eczema characterized by itch, sleeplessness, and adverse effects on quality of life is associated with a risk of hematological malignancies. However, there is a controversy pertaining to whether this association implies a greater or lesser risk of hematological cancers. …”

Data_Sheet_1_HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis.docx by Zhenyu Zhong (6861935)

“…Genetically proxied inhibition of HMGCR scaled to per mmol/L decrease in LDL cholesterol levels by the HMGCR score was associated with a lower risk of ankylosing spondylitis (OR, 0.57; 95% CI, 0.38–0.85; P value = 5.7 × 10^–3). …”

C/EBPβ and A20 (TNFAIP3) were suppressed in <i>Ikkβ</i>^Δ and p38-inhibited macrophages. by Ting-Yu Lai (452775)

“…<p>(A–C) Expression levels of <i>Tnfaip3</i> and <i>Cebpb</i> mRNA were decreased in <i>Ikkβ</i>^Δ and p38-inhibited BMDMs in response to LPS. …”

Image_2_27-hydroxycholesterol and DNA damage repair: implication in prostate cancer.jpeg by Gloria Cecilia Galvan (17686206)

“…Consistently, we found a correlation between higher CYP27A1 expression (i.e., higher intracellular 27HC) and decreased expression of DNA repair gene signatures in castration-sensitive PC (CSPC) in human PC datasets. …”

Image_2_27-hydroxycholesterol and DNA damage repair: implication in prostate cancer.jpeg by Gloria Cecilia Galvan (17686206)

“…Consistently, we found a correlation between higher CYP27A1 expression (i.e., higher intracellular 27HC) and decreased expression of DNA repair gene signatures in castration-sensitive PC (CSPC) in human PC datasets. …”

Image_1_27-hydroxycholesterol and DNA damage repair: implication in prostate cancer.jpeg by Gloria Cecilia Galvan (17686206)

“…Consistently, we found a correlation between higher CYP27A1 expression (i.e., higher intracellular 27HC) and decreased expression of DNA repair gene signatures in castration-sensitive PC (CSPC) in human PC datasets. …”

Image_1_27-hydroxycholesterol and DNA damage repair: implication in prostate cancer.jpeg by Gloria Cecilia Galvan (17686206)

“…Consistently, we found a correlation between higher CYP27A1 expression (i.e., higher intracellular 27HC) and decreased expression of DNA repair gene signatures in castration-sensitive PC (CSPC) in human PC datasets. …”

The memory capacity for a single sequence. by Nadav Ben-Shushan (4678807)

“…<p>(A) The memory capacity normalized by the network size as function of λ—the largest eigenvalue of the connectivity matrix <b>W</b> in absolute value. …”

siRNA for STAT3 inhibits LPS-activated and/or HIV-1-infected MCM-induced increase of astrocyte and decrease of neuronal proportions. by Hui Peng (116756)

This patient is a 42-year-old man seen 11 months after receiving a burn on the thigh by John R. Danielson (63285)

“…On 7-week follow-up after treatment with salicylic acid and hydrogel (right panel), the scar showed a notable decrease in redness and thickness and the patient reported diminished pruritus.…”

A histogram of %ID/g for various organs in a model mouse 90 min after blocking with liraglutide. by Jing Lv (128179)

Group-level results (confirmation sample). by Jacqueline Scholl (3752851)

“…Participants also adjust their estimate of prospective value (“ProspVS1-Adapted”) as it decreased over time as fewer and fewer available searches remained in a trial (mean = −0.03, 95% CI [−0.04 to −0.03]). …”

Table_3_Endothelin-A Receptor Antagonist Alleviates Allergic Airway Inflammation via the Inhibition of ILC2 Function.xlsx by Xiaogang Zhang (1282050)

“…<p>Allergic airway inflammation is a universal airway disease that is driven by hyperresponsiveness to inhaled allergens. …”