C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Further mechanism studies showed that inhibiting C5aR1 by PMX53 protected the rats from MCAO/R injury, decreased cell inflammation, and apoptosis via inhibiting the TLR4 and NF-κB signaling pathway and reducing the production of TNF-α, IL-1β, and IL-6 in MCAO/R rats. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Further mechanism studies showed that inhibiting C5aR1 by PMX53 protected the rats from MCAO/R injury, decreased cell inflammation, and apoptosis via inhibiting the TLR4 and NF-κB signaling pathway and reducing the production of TNF-α, IL-1β, and IL-6 in MCAO/R rats. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Further mechanism studies showed that inhibiting C5aR1 by PMX53 protected the rats from MCAO/R injury, decreased cell inflammation, and apoptosis via inhibiting the TLR4 and NF-κB signaling pathway and reducing the production of TNF-α, IL-1β, and IL-6 in MCAO/R rats. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Further mechanism studies showed that inhibiting C5aR1 by PMX53 protected the rats from MCAO/R injury, decreased cell inflammation, and apoptosis via inhibiting the TLR4 and NF-κB signaling pathway and reducing the production of TNF-α, IL-1β, and IL-6 in MCAO/R rats. …”

Calves diagnosed as a case of bovine respiratory disease (BRD) by thoracic lung ultrasonography scoring and Wisconsin health scoring (WHS). by Cian Reid (17274007)

Money Affects Theory of Mind Differently by Gender by Garret Ridinger (833327)

“…RMET scores do not significantly change when monetary earnings go to a charity. Whether money improves or hinders ToM ability, and, hence, success in social interactions, thus depends on the interaction of gender and monetary incentive structure.…”

Cytokine Kinetics in the First Week of Tuberculosis Therapy as a Tool to Confirm a Clinical Diagnosis and Guide Therapy by Alice L. den Hertog (340331)

“…</p><p>Results</p><p>Changes in concentrations of non-specific host biomarkers, particularly IP-10, in response to the first week of anti-TB therapy were strongly associated with bacteriological confirmation of TB. A decrease in IP-10 level of >300pg/ml between 0 and 7 days of treatment identified 75% of both smear-positive and smear-negative culture positive patients and correctly excluded TB in all nine culture negative patients.…”

Mutations close to a hub residue affect the distant active site of a GH1 β-glucosidase by Valquiria P. Souza (3392195)

“…Replacement of residues A263 and A264, which side-chains project from the α-helix towards F251, decreased the rate of substrate hydrolysis. …”

Longitudinal engagement trajectories and risk of death among new ART starters in Zambia: A group-based multi-trajectory analysis by Aaloke Mody (602279)

“…Identified groups exhibited large differences in survival: after adjustment, the “early LTFU with reengagement” group (aIRR 3.4 [95% CI 1.2–9.7], <i>p =</i> 0.019), the “early LTFU” group (aIRR 6.4 [95% CI 2.5–16.3], <i>p <</i> 0.001), and the “late LTFU” group (aIRR 4.7 [95% CI 2.0–11.3], <i>p =</i> 0.001) had higher rates of mortality as compared to the group with consistently high adherence/retention. …”

Phylodynamic analysis of genotype A in Japan. by Serena Y. C. Lin (2826563)

“…The Upper HPD 95% shows stable population maintaining over time while the Lower HPD 95% of effective number of viral population suggests exponential growing from early 1990 and a quick decline after 2003. However, the mean of genetic diversity (the solid black line) revealed that HBV/A population is substantially increasing from 1990 to 2003 and decreased since 2005.…”

Factors associated with stunting in healthy children aged 5 years and less living in Bangui (RCA) by Pascale Vonaesch (149522)

“…<div><p>Stunting remains a major public health concern worldwide. Although its global prevalence is slowly decreasing, the actual number of affected children is still rising in Sub-Saharan Africa. …”

Leucophore formation does not require Sox10 function but is repressed by Sox10 and Sox5 (A-H) 9 dpf. by Yusuke Nagao (546940)

“…Leucophores (orange) are distributed along the dorsal surface throughout the anterioposterior axis of WT, as scattered individual cells in the head, and along the midline in the body (A). As the number of functional <i>sox10</i> alleles decreases, leucophore numbers on the head are progressively increased (A-D, I, <i>p</i><0.05 by Kruskal-Wallis test), whereas in the body they are progressively decreased (J, <i>p</i><0.05 by Kruskal-Wallis test). …”

Illustration and diagram showing a gain function of a single dive with the optimal patch time according to the assumption of CPF. by Yu Akiyama (6298235)

“…Here, the prey density is predicted to decrease after each lunge showing a shape of a diminishing rate of energy gain (slope of a line). …”

A daily living function assessment. by Yoriko Aoki (17847445)

“…<div><p>Background</p><p>In Japanese medical practice, older stroke survivors are overwhelmed with information regarding their discharge locations, creating more decision-making challenges. A randomized controlled trial evaluated the influence of decision aids (DAs) for matching older stroke patients and their families’ values concerning decisional conflict and participation in discharge destination decisions.…”

Intronic SNPs of <i>POLG1</i> gene associate with decreased <i>POLG1</i> mRNA and protein levels. by Ya-xing Gui (112406)

Identification of a Novel Variant <i>c.163delG</i> in <i>HBB</i> Gene Resulting in a Beta Null Phenotype in a Proband with Thalassemia Intermedia by M. Mamata (17831752)

“…FoldX protein stability analysis showed a positive ΔΔG value of 45.27 kcal/mol suggesting a decrease in protein stability. …”

Construction and calibration of a bar weighing lysimeter by Daiane de Cinque Mariano (10413858)

“…Calibration of each lysimeter was performed after field installation. The results showed a linear response (R2 > 0.9999) of electric signal (mV) to mass increase or decrease (kg) with minimum hysteresis. …”

Test with a separable stochastic subsystem. by James C. Schaff (3396203)

“…(B) The multi-trial mean, , converges to an exact expectation value with the increasing number of trials and decreasing time step <i>Δt</i> (data points for <i>Δt</i> = 0.02 s, 0.006 s, and 0.002 s are shown as triangles, squares, and circles, respectively). …”

9,10-Anthraquinones Disubstituted with Linear Alkoxy Groups: Spectroscopy, Electrochemistry, and Peculiarities of Their 2D and 3D Supramolecular Organizations by Agnieszka Maranda-Niedbała (9728700)

“…The first reduction was affected by electron-donating properties of the substituents, its potential being shifted to ca. −1.5 V (vs Fc/Fc⁺), i.e., by 80 to 95 mV as compared to the case of unsubstituted anthraquinone. This corresponded to a decrease of |EA| from 3.27 to 3.19–3.17 eV. The experimental spectroscopic and electrochemical data were in full agreement with the DFT calculations. …”

Read counts for "<b>Propionate Decreases Microglial Activation but Impairs Phagocytic Capacity in response to Aggregated Fibrillar Amyloid Beta Protein</b>" by Andrew Gold (19532335)

“…Finally, propionate shifted microglial metabolism, altering phospholipid composition and diverting arginine metabolism, resulting in decreased nitric oxide production. Altogether, our data demonstrate a modulatory role of propionate on microglia that may dampen immune activation in response to Aβ, although at the expense of phagocytic capacity.…”