Growth of certain cancer cell lines requires IRE1 but not its enzymatic activity. by Iratxe Zuazo-Gaztelu (21071939)

The Role of <i>TLR4</i> 896 A><i>G</i> and 1196 C><i>T</i> in Susceptibility to Infections: A Review and Meta-Analysis of Genetic Association Studies by Panayiotis D. Ziakas (464048)

“…</p> <p>Conclusions</p><p>Depending on the type of infection and population, TLR4 polymorphisms are associated with increased, decreased or no difference in infectious disease. This may be due to differential functional expression of TLR4, the co-segregation of TLR4 variants or a favorable inflammatory response.…”

SOCS-inducing cytokines IFN-α, IFN-γ, and IL-6, but not IFN-β, are transcriptionally stimulated during MCMV infection of MEFs. by Christine I. Alston (3737545)

A potential mechanism of EPSAH-induced cell apoptosis in HeLa cells. by Yu Ou (405565)

Cnot4 Het does not affect mRNA expression of metabolic genes as well as serum lipid levels or glucose tolerance. by Tomokazu Yamaguchi (8284989)

Data_Sheet_1_Efficacy and feasibility of a 12-week Tai Chi training for the prophylaxis of episodic migraine in Hong Kong Chinese women: A randomized controlled trial.docx by Yao Jie Xie (10073843)

“…The purpose of this study was to preliminarily examine the efficacy and feasibility of a 12-week Tai Chi training on migraine attack prevention in a sample of Chinese women.…”

Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glio... by Qingqing Zhou (3801922)

“…To assess the anticancer potential of inhibitors targeting DYRK kinases, we developed a series of novel DYRK inhibitors based on the 7-azaindole scaffold. …”

Cnot4 heterozygosity confers resistance to high fat diet-induced obesity. by Tomokazu Yamaguchi (8284989)

Fusion of APP CTF to PS1 N-terminus produces Aβ, while fusion of APP CTF to FAD-linked PS1 variant overproduces Aβ42. by Naoyuki Sato (119858)

“…Note that DAPT treatment decreased Aβ40 secreted from PS (−/−) cells expressing the fusion protein. …”

Reduced <i>ccna2</i> and <i>ccnd1</i> expression in <i>ddb1</i>^<i>m863</i> mutant embryos. by Zhilian Hu (777443)

“…<p>(A-D) Expression pattern of <i>ccna2</i> in wild type siblings. …”

K13 shows an increased association with the mitochondria post DHA pulse. by Nina F. Gnädig (8735760)

Blocking of DL1-platelet binding by Hsa-BR in whole human blood. by Lingquan Deng (669704)

“…(C–E) Whole blood with different concentrations of Hsa-BR added first, followed by DL1-Cy3 and CD41a-APC. Increasing amount of Hsa-BR results in decreasing count of DL1-bound platelets (Q2 percentages) and increasing numbers of free bacteria (Q3 percentages). …”

CNP lowered GAPDH activity in melanoma cells. by Claudia von Montfort (256730)

Lactate administration partially rescues CNP induced toxicity in melanoma cells. by Claudia von Montfort (256730)

Fruits Produce Branched-Chain Esters Primarily from Newly Synthesized Precursors by Philip Engelgau (20692628)

“…., those related to isoleucine, and valine and leucine, respectively) universally decreased in content by at least 90%. Among free amino acids, only the branched-chain amino acids, with correspondingly reduced branched-chain esters, had a lesser concentration following treatment with the inhibitor. …”

Aza-Residue Modulation of Cyclic d,l‑α-Peptide Nanotube Assembly with Enhanced Anti-Amyloidogenic Activity by Maram Habashi (14599521)

“…Substitution of the l-norleucine³ and d-serine⁶ residues in peptide <b>1</b> with aza-norleucine and aza-homoserine provided, respectively, nontoxic [azaNle³]-<b>1</b> (<b>4</b>) and [azaHse⁶]-<b>1</b> (<b>7</b>), that significantly abated symptoms in a transgenic Caenorhabditis elegans AD model by decreasing Aβ oligomer levels.…”

Table_1_Proteomic Investigation Reveals Eukaryotic Translation Initiation Factor 5A Involvement in Porcine Reproductive and Respiratory Syndrome Virus Infection in vitro.XLSX by Huawei Li (277669)

“…Analysis of the results led to identification of 269 significantly differentially expressed host cellular proteins, of which levels of proteins belonging to the eukaryotic translation initiation factor (eIF) family were found to be decreased in abundance in HP-PRRSV-infected PAMs. Furthermore, knockdown of eIF5A expression was demonstrated to markedly suppress HP-PRRSV propagation, as reflected by reduced progeny virus titers in vitro. …”

Data_Sheet_1_Proteomic Investigation Reveals Eukaryotic Translation Initiation Factor 5A Involvement in Porcine Reproductive and Respiratory Syndrome Virus Infection in vitro.DOCX by Huawei Li (277669)

“…Analysis of the results led to identification of 269 significantly differentially expressed host cellular proteins, of which levels of proteins belonging to the eukaryotic translation initiation factor (eIF) family were found to be decreased in abundance in HP-PRRSV-infected PAMs. Furthermore, knockdown of eIF5A expression was demonstrated to markedly suppress HP-PRRSV propagation, as reflected by reduced progeny virus titers in vitro. …”

Model of the control of DgcE activity by the GTPase RdcA and its accessory factor RdcB. by Vanessa Pfiffer (6635057)

“…<b>B:</b> During entry into stationary phase, the cellular GTP level is decreased substantially, the RdcA/RdcB complex is predominantly in the nucleotide-free form that binds to the MASE1 domains of two DgcE molecules, which promotes an alignment of the PAS₃ and GGDEF domains, thereby overcoming the anti-oligomerizing effect of the EAL domain of DgcE. …”

Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development by Meizhu Bai (6905372)

“…However, such screens are successful only in lower organisms. Here, we develop a targeted genetic screening approach in mice through combining androgenetic haploid embryonic stem cells (AG-haESCs) and clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9 (CRISPR-Cas9) technology. …”