Fusion of APP CTF to PS1 N-terminus produces Aβ, while fusion of APP CTF to FAD-linked PS1 variant overproduces Aβ42. by Naoyuki Sato (119858)

“…Note that DAPT treatment decreased Aβ40 secreted from PS (−/−) cells expressing the fusion protein. …”

Cnot4 Het does not affect mRNA expression of metabolic genes as well as serum lipid levels or glucose tolerance. by Tomokazu Yamaguchi (8284989)

Cnot4 heterozygosity confers resistance to high fat diet-induced obesity. by Tomokazu Yamaguchi (8284989)

Aza-Residue Modulation of Cyclic d,l‑α-Peptide Nanotube Assembly with Enhanced Anti-Amyloidogenic Activity by Maram Habashi (14599521)

“…Substitution of the l-norleucine³ and d-serine⁶ residues in peptide <b>1</b> with aza-norleucine and aza-homoserine provided, respectively, nontoxic [azaNle³]-<b>1</b> (<b>4</b>) and [azaHse⁶]-<b>1</b> (<b>7</b>), that significantly abated symptoms in a transgenic Caenorhabditis elegans AD model by decreasing Aβ oligomer levels.…”

Table_1_Proteomic Investigation Reveals Eukaryotic Translation Initiation Factor 5A Involvement in Porcine Reproductive and Respiratory Syndrome Virus Infection in vitro.XLSX by Huawei Li (277669)

“…Analysis of the results led to identification of 269 significantly differentially expressed host cellular proteins, of which levels of proteins belonging to the eukaryotic translation initiation factor (eIF) family were found to be decreased in abundance in HP-PRRSV-infected PAMs. Furthermore, knockdown of eIF5A expression was demonstrated to markedly suppress HP-PRRSV propagation, as reflected by reduced progeny virus titers in vitro. …”

Data_Sheet_1_Proteomic Investigation Reveals Eukaryotic Translation Initiation Factor 5A Involvement in Porcine Reproductive and Respiratory Syndrome Virus Infection in vitro.DOCX by Huawei Li (277669)

“…Analysis of the results led to identification of 269 significantly differentially expressed host cellular proteins, of which levels of proteins belonging to the eukaryotic translation initiation factor (eIF) family were found to be decreased in abundance in HP-PRRSV-infected PAMs. Furthermore, knockdown of eIF5A expression was demonstrated to markedly suppress HP-PRRSV propagation, as reflected by reduced progeny virus titers in vitro. …”

Model of the control of DgcE activity by the GTPase RdcA and its accessory factor RdcB. by Vanessa Pfiffer (6635057)

“…<b>B:</b> During entry into stationary phase, the cellular GTP level is decreased substantially, the RdcA/RdcB complex is predominantly in the nucleotide-free form that binds to the MASE1 domains of two DgcE molecules, which promotes an alignment of the PAS₃ and GGDEF domains, thereby overcoming the anti-oligomerizing effect of the EAL domain of DgcE. …”

K13 shows an increased association with the mitochondria post DHA pulse. by Nina F. Gnädig (8735760)

Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development by Meizhu Bai (6905372)

“…However, such screens are successful only in lower organisms. Here, we develop a targeted genetic screening approach in mice through combining androgenetic haploid embryonic stem cells (AG-haESCs) and clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9 (CRISPR-Cas9) technology. …”

Image_1_Identification of Regulatory Genes and Metabolic Processes Important for Alginate Biosynthesis in Azotobacter vinelandii by Screening of a Transposon Insertion Mutant Libra... by Mali Mærk (792850)

“…One mutant, containing a mucA disruption, displayed an elevated alginate production level, and several mutants with decreased or abolished alginate production were identified. …”

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation by Christian Berrios (127454)

“…While MYC was required for MCT1 induction, MCPyV-induced MCT1 levels decreased following knockdown of the NF-κB subunit RelA, supporting a synergistic activity between MCPyV and MYC in regulating MCT1 levels. …”

CNP lowered GAPDH activity in melanoma cells. by Claudia von Montfort (256730)

Lactate administration partially rescues CNP induced toxicity in melanoma cells. by Claudia von Montfort (256730)

Fruits Produce Branched-Chain Esters Primarily from Newly Synthesized Precursors by Philip Engelgau (20692628)

“…., those related to isoleucine, and valine and leucine, respectively) universally decreased in content by at least 90%. Among free amino acids, only the branched-chain amino acids, with correspondingly reduced branched-chain esters, had a lesser concentration following treatment with the inhibitor. …”

Impact of social isolation by Coronavirus disease 2019 in food: a narrative review by Luísa Harumi MATSUO (10351001)

“…A decrease in fish consumption and an increase in comfort foods were also reported. …”

Carotid Sinus Massage in Syncope Evaluation: A Nonspecific and Dubious Diagnostic Method by Tan Chen Wu (5172170)

“…Symptoms were reported especially in those patients in whom CSM caused a SBP decrease to below 90 mmHg and/or asystole > 2.5 seconds, regardless of the pattern of response or the presence of previous syncope. …”

MOR activation inhibits glutamate release onto a subset of LHb neurons. by Elyssa B. Margolis (148265)

“…(C) Example traces from a neuron where DAMGO decreased the frequency, but not the amplitude, of sEPSCs. …”

Carotid Sinus Massage in Syncope Evaluation: A Nonspecific and Dubious Diagnostic Method by Tan Chen Wu (5172170)

“…Symptoms were reported especially in those patients in whom CSM caused a SBP decrease to below 90 mmHg and/or asystole > 2.5 seconds, regardless of the pattern of response or the presence of previous syncope. …”

Photoreceptor cell death and protective effect of the blue-blocking filter on cone photoreceptors. by Javier Vicente-Tejedor (4966858)

p53 activation fails to increase mRNA levels in Δ40p53:WTp53 cells. by Cecilia B. Levandowski (11238230)

“…<p><b>(A)</b> Volcano plots showing differentially expressed mRNAs after 20-hour Nutlin treatment (vs. …”